The HLA class II transcriptional activator blocks the function of HIV-1 Tat and inhibits viral replication

European Journal of Immunology

Volumn 32, Issue 10, 2002, Pages 2783-2791

  Accolla, Roberto S ^a,b   Mazza, Stefania ^a   De Lerma Barbaro, Andrea ^a   De Maria, Andrea ^c   Tosi, Giovanna ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b Advanced Biotechnology Center   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

AIR 1; CIITA; Cyclin T1; HIV 1 replication; Tat

Indexed keywords

COMPLEMENTARY DNA; CYCLIN T1; ELONGATION FACTOR; HLA ANTIGEN CLASS 2; TRANSACTIVATOR PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION SENSITIVITY; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; TRANSACTIVATION; TRANSCRIPTION INITIATION; VIRUS EXPRESSION; VIRUS REACTIVATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

GENE PRODUCTS, TAT; HELA CELLS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; VIRUS REPLICATION;

EID: 0036772948     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2002010)32:10<2783::AID-IMMU2783>3.0.CO;2-E     Document Type: Article

References (36)

1. Pantaleo, G. and Fauci, A. S., Immunopathogenesis of HIV infection. Annu. Rev. Microbiol. 1996. 50: 825-854.
2. Emerman, M. and Malim, M. H., HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science 1998. 280: 1880-1884.
3. Jones, K. A. and Peterlin, B. M., Control of RNA initiation and elongation at the HIV-promoter. Annu. Rev. Biochem. 1994. 63: 717-743.
4. Wei, P., Gerber, M. E., Fang, S. M., Fisher, W. H. and Jones, K. A., A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 1998. 92: 451-462.
5. Frankel, A. D. and Pabo, C. O., Cellular uptake of the Tat protein from human immunodeficiency virus. Cell 1988. 164: 280-284.
6. Goldstein, G., HIV-1 Tat protein as a potential AIDS vaccine. Nat. Med. 1996. 1: 960-964.
7. Gallo, R. C., Tat as one key to HIV-induced immune pathogenesis and Tat toxoid as an important component of a vaccine. Proc. Natl. Acad. Sci. USA 1999. 96: 8324-8326.
8. Caputo, A., Grossi, M. P., Bozzini, R., Rossi, C., Betti, M., Marconi, P. C., Barbanti Brodano, G. and Balboni, P. G., Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region. Gene Ther. 1996. 3: 235-245.
9. Cafaro, A., Caputo, A., Fracasso, C., Maggiorella, M. T., Goletti, D., Baroncelli, S., Pace, M., Sernicola, L., Koanga-Mogtomo, M. L., Betti, M., Borsetti, A., Belli, R., Akerblom, L., Corrias, F., Buttò, S., Heeney, J., Verani, P., Titti, F. and Ensoli, B., Control of SHIV-89. 6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine. Nat. Med. 1999. 5: 643-650.
10. Howcroft, T. K., Strebel, K., Martin, M. A. and Singer, D. S., Repression of MHC class I gene promoter activity by two-exon Tat of HIV. Science 1993. 260: 1320-1322.
11. Matsui, M., Warburton, R. J., Cogswell, P. C., Baldwin, A. S. Jr. and Frelinger, J. A., Effect of HIV-1 Tat on expression of HLA class I molecules. J. Acquir. Imm. Defic. Syndr. Hum. Retrovirol. 1996. 11: 233-240.
12. Tosi, G., De Lerma Barbaro, A., D'Agostino, A., Valle, M. T., Megiovanni, A. M., Manca, F., Caputo, A., Barbanti-Brodano, G. and Accolla, R. S., HIV-1 Tat mutants in the cysteine-rich region down-regulate HLA class II expression in T lymphocytic and macrophage cell lines. Eur. J. Immunol. 2000. 30: 19-28.
13. Germain, R. N. and Margulies, D. H., The biochemistry and cellular biology of antigen processing and presentation. Annu. Rev. Immunol. 1993. 11: 403-450.
14. Petit, C. A. J., Terpstra, F. G. and Miedema, F., Human immunodeficiency virus infection down-regulates HLA class II expression and induces differentiation in promonocytic U937 cells. J. Clin. Invest. 1987. 79: 1883-1889.
15. Polyak, S., Chen, H., Hirsch, D., George, I., Herschberg, R. and Sperber, K., Impaired class II expression and antigen uptake in monocytic cells after HIV-1 infection. J. Immunol. 1997. 159: 2177-2188.
16. Kornbluth, R. S., Oh, P. S., Munis, J. R., Cleveland, P. H. and Richman, D. D., Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J. Exp. Med. 1989. 169: 1137-1151.
17. Bovolenta, C., Lorini, A. L., Mantelli, B., Camorali, L., Novelli, F., Biswas, P. and Poli, G., A selective defect of IFN-gamma-but not of IFN-alpha-induced JAK/STAT pathway in a subset of U937 clones prevents antiretroviral effect of IFN-γ against HIV-1. J. Immunol. 1999. 162: 323-330.
18. Kanazawa, S., Okamoto, T. and Peterlin, B. M., Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity 2000. 12: 61-70.
19. Accolla, R. S., Jotterand-Bellomo, M., Scarpellino, L., Maffei, A., Carra, G. and Guardiola, J., alr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression. J. Exp. Med. 1986. 164: 369-374.
20. Steimle, V., Often, L. A., Zufferey, M. and Mach, B., Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or Bare Lymphocyte Syndrome). Cell 1993. 75: 135-146.
21. Steimle, V., Siegrist, C. A., Mottet, A., Lisowska-Grospierre, B. and Mach, B., Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA. Science 1994. 265: 106-109.
22. Rigaud, G., De Lerma Barbaro, A., Nicolis, M., Cestari, T., Ramarli, D., Riviera, A. P. and Accolla, R. S., Induction of CIITA and modification of in vivo HLA-DR promoter occupancy in normal thymic epithelial cells treated with IFN-γ. J. Immunol. 1996. 156: 4254-4258.
23. Wright, C. M., Selber, B. K., Paskalis, H. and Pavlakis, G. N., Expression and characterization of the trans-activator of HTILV-III/LAV virus. Science 1986. 234: 988-992.
24. Kretsovali, A., Agalioti, T., Spilianakis, C., Tzortzakaki, E., Merika, M. and Papamatheakis, J., Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 1998. 18: 6777-6783.
25. Marzio, G., Tyagi, M., Gutierrez, M. I. and Giacca, M., HIV Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc. Natl. Acad. Sci. USA 1998. 95: 13519-13524.
26. Saifuddin, M., Roebuck, K. A., Chang, C. H., Ting, J.-P. Y. and Spear, G. T., Cutting edge: Activation of HIV-1 transcription by the MHC class II transactivator. J. Immunol. 2000. 164: 3941-3945.
27. Tosi, G., Meazza, R., De Lerma Barbaro, A., D'Agostino, A., Mazza, S., Corradin, G. P., Albini, A., Noonan, D. M., Ferrini, S. and Accolla, R. S., Highly stable oligomerization forms of HIV-1 tat detected by monoclonal antibodies and requirement of monomeric forms for the transactivating function on the HIV-1 LTR. Eur. J. Immunol. 2000. 30: 1120-1126.
28. Okamoto, H., Asamitsu, K., Nishimura, H., Kamatani, N. and Okamoto, T., Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA. Bioch. Biophys. Res. Commun. 2000. 279: 494-499.
29. Nabel, G. and Baltimore, D., An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 1987. 326: 711-713.
30. Ko, H.-S., Fu, S. M., Winchester, R. J., Yu, D. T. Y. and Kunkel, H. G., Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen and antigen-activated T cells. J. Exp. Med. 1979. 150: 246-253.
31. Reinherz, E. L., Kung, P. C., Pesando, J. R., Ritz, J., Goldstein, C. and Schlossman, S. F., la determinants on human T cell subsets defined by monoclonal antibodies. Activation stimuli required for expression. J. Exp. Med. 1979; 150: 1472-1482.
32. Tortorella, D., Gewurz, B. A., Furman, M. H., Schust, D. J. and Ploegh, H. L., Viral subversion of the immune system. Annu. Rev. Immunol. 2000. 18: 861-926.
33. + T cell response is mediated by repression of gamma interferon-induced class II transactivator expression. J. Virol. 1999. 73: 6582-6589.
34. Accolla, R. S., De Lerma Barbaro, A., Mazza, S., Casoli, C., De Maria, A. and Tosi, G., The MHC class II transactivator: prey and hunter in infectious diseases. Trends Immunol. 2001. 22: 560-563.
35. Sartoris, S., Valle, M. T., De Lerma Barbaro, A., Tosi, G., Cestari, T., D'Agostino, A., Megiovanni, A. M., Manca, F. and Accolla, R. S., Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histo-compatibility complex class II gene expression observed during differentiation from B cells to plasma cells. Eur. J. Immunol. 1996. 26: 2456-2460.
36. + cytolitic T lymphocytes become infected in vitro in the process of killing HIV-1 -infected targets. Eur. J. Immunol. 1994. 24: