The MHC class II transactivator: Prey and hunter in infectious diseases

Trends in Immunology

Volumn 22, Issue 10, 2001, Pages 560-563

  Accolla, Roberto S ^a   De Lerma Barbaro, Andrea ^a   Mazza, Stefania ^a   Casoli, Claudio ^b   De Maria, Andrea ^c   Tosi, Giovanna ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSACTIVATOR PROTEIN;

ANTIGEN DETECTION; BACTERIAL INFECTION; BACTERIUM; GENE EXPRESSION REGULATION; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOREGULATION; INFECTION RESISTANCE; REVIEW; VIRUS; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; COMMUNICABLE DISEASES; GENES, MHC CLASS II; HUMANS; NUCLEAR PROTEINS; TRANS-ACTIVATORS;

EID: 0035471917     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)02003-8     Document Type: Review

References (29)

1. Viral subversion of the immune system
2. AIR-1, a newly found locus on mouse chromosome 16 encoding a transacting activator factor for MHC class II gene expression
3. MHC class II gene regulation: Some considerations on a still ontogenetic and phylogenetic puzzle
4. Class II transactivator: Mastering the art of major histocompatibility complex expression
5. Human B-cell variants immunoselected against a single Ia subset have lost expression of several Ia antigen subsets
6. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
7. Combined immunodeficiency with defective expression in MHC class II genes
8. STATs and gene regulation
9. Activation of the MHC class II transactivator CIITA by interferon γ requires cooperative interaction between Stat1 and USF-1
10. STAT-1α expression is involved in IFN-γ induction of the class II transactivator and class II MHC genes
11. Distinct regulation of HLA class II and class I cell surface expression in THP-1 macrophage cell line after bacterial phagocytosis
12. Chlamydia inhibits interferon γ-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1
13. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guérin involves class II transactivator and depends on the Nramp1 gene
14. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
15. + T-cell response is mediated by repression of γ interferon-induced class II transactivator expression
16. Modulation of major histocompatibility class II protein expression by Varicella Zoster virus
17. Reduced IL-4-, lipopolysaccharide- and IFN γ-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain
18. + hematopoietic precursors by increasing their survival potential. Envelope-associated HLA class II molecules reverse this effect
19. A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
20. Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
21. Tat competes with CIITA for binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection
22. HIV-Tat mutants in the cysteine-rich region down-regulate HLA class II expression in T lymphocytic and macrophage cell lines
23. Cutting edge: Activation of HIV-1 transcription by the MHC class II transactivator
24. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
25. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator
26. HIV Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
27. The biochemistry and cellular biology of antigen processing and presentation
28. A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production
29. Cutting edge: The class II transactivator prevents activation-induced cell death by inhibiting Fas ligand gene expression