Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice

Toxicological Sciences

Volumn 69, Issue 2, 2002, Pages 317-321

  Kashida, Yoko ^a   Sasaki, Yu F ^b   Ohsawa, Koh Ichi ^b   Yokohama, Natsue ^b   Takahashi, Akiko ^a   Watanabe, Takao ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b HACHINOHE NATIONAL COLLEGE OF TECHNOLOGY   (Japan)

Author keywords

Carcinogenicity study; Comet assay; DNA damage; DNA gyrase; Flumequine; Topoisomerase II

Indexed keywords

BACTERIAL ENZYME; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; DRINKING WATER; FLUMEQUINE; GALACTOSAMINE; PHENOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; COLON; COMET ASSAY; CONTROLLED STUDY; DIET THERAPY; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; ENZYME INHIBITION; EUKARYOTE; GEL ELECTROPHORESIS; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; MALE; MOUSE; NONHUMAN; STOMACH; TUMOR PROMOTION;

ANIMALS; ANTI-INFECTIVE AGENTS; CARCINOGENICITY TESTS; CARCINOGENS; CELL LINE; CELL NUCLEUS; COMET ASSAY; DNA DAMAGE; DNA GYRASE; DNA TOPOISOMERASES, TYPE II; FLUOROQUINOLONES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C3H; PHENOBARBITAL; QUINOLIZINES;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 0036772742     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.2.317     Document Type: Article

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