Phosphatidylinositol 3′-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells

Neuro-Oncology

Volumn 4, Issue 4, 2002, Pages 242-252

  Woods, Stacy A ^a   McGlade, C Jane ^a   Guha, Abhijit ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; VASCULOTROPIN; 1,3 BUTADIENE DERIVATIVE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENDOTHELIAL CELL GROWTH FACTOR; ENZYME INHIBITOR; HRAS PROTEIN, HUMAN; LYMPHOKINE; MAP2K1 PROTEIN, HUMAN; MAP2K2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MORPHOLINE DERIVATIVE; NITRILE; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; VASCULOTROPIN A;

ANGIOGENESIS; ARTICLE; ASTROCYTOMA CELL; CANCER GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HYPOXIA; NORTHERN BLOTTING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE OXYGENATION; TUMOR VASCULARIZATION; ASTROCYTOMA; CELL HYPOXIA; CENTRAL NERVOUS SYSTEM TUMOR; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ASTROCYTOMA; BLOTTING, NORTHERN; BLOTTING, WESTERN; BUTADIENES; CELL HYPOXIA; CELL LINE; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHROMONES; ENDOTHELIAL GROWTH FACTORS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MORPHOLINES; NEOVASCULARIZATION, PATHOLOGIC; NITRILES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RNA, MESSENGER; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036771770     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/S1522851702000030     Document Type: Article

References (38)

1. Bouterfa, H.L., Sattelmeyer, V, Czub, S., Vordermark, D., Roosen, K., and Tonn, J.C. (2000) Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells. Anticancer Res. 20, 2761-2771.
2. Damert, A., Ikeda, E., and Risau, W. (1997) Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem. J., 327, 419-423.
3. Feldkamp, M., Lau, N., Roncari, L., and Guha, A. (2001) Isotype-specific Ras.GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status. Cancer Res. 61, 4425-4431.
4. Feldkamp, M.M., Lau, N., and Guha, A. (1999a) The farnesyltransferase inhibitor L-744,832 inhibits the growth of astrocytomas through a combination of anti proliferative, antiangiogenic, and proapoptotic activities. Ann. N.Y. Acad. Sci. 886, 257-260.
5. Feldkamp, M.M., Lau, N., and Guha, A. (1999b) Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. Oncogene 18, 7514-7526.
6. Feldkamp, M.M., Lau, N., Rak, J., Kerbel, R.S., and Guha, A. (1999c) Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras. Int. J. Cancer 81, 118-124.
7. Finkenzeller, G., Sparacio, A., Technau, A., Marme, D., and Siemeister, G. (1997) Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene 15, 669-676.
8. Finkenzeller, G., Technau, A., and Marme, D. (1995) Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem. Biophys. Res. Commun. 208, 432-439.
9. Forsythe, J.A., Jiang, B.H., Iyer, N.V., Agani, F, Leung, S.W., Koos, R.D., and Semenza, G.L. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16, 4604-4613.
10. Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B., and Marme, D. (1995) Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem. 270, 25915-25919.
11. Guha, A., Feldkamp, M.M., Lau, N., Boss, G., and Pawson, A. (1997) Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 15, 2755-2765.
12. Hashimoto, E., Ogita, T., Nakaoka, T, Matsuoka, R., Takao, A., and Kira, Y. (1994) Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267, H1948-H1954.
13. Horiuchi, T., and Weller, P.F. (1997) Expression of vascular endothelial growth factor by human eosinophils: Upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5. Am. J. Respir. Cell Mol. Biol. 17, 70-77.
14. Jiang, B.H., Zheng, J.Z., Aoki, M., and Vogt, P.K. (2000) Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 97, 1749-1753.
15. Jung, Y.D., Nakano, K., Liu, W., Gallick, G.E., and Ellis, L.M. (1999) Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. Cancer Res. 59, 4804-4807.
16. Ladoux, A., and Frelin, C. (1993) Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem. Biophys. Res. Commun. 195, 1005-1010.
17. Larcher, F, Robles, A.I., Duran, H., Murillas, R., Quintanilla, M., Cano, A., Conti, C.J., and Jorcano, J.L. (1996) Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res. 56, 5391-5396.
18. Levy, A.P., Levy, N.S., and Goldberg, M.A. (1996) Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271, 2746-2753.
19. Mahaley, M.S., Jr., Mettlin, C., Natarajan, N., Laws, E.R., Jr, and Peace, B.B. (1989) National survey of patterns of care for brain-tumor patients. J. Neurosurg. 71, 826-836.
20. Maity, A., Pore, N., Lee, J., Solomon, D., and O'Rourke, D. (2000) Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3′-kinase and distinct from that induced by hypoxia. Cancer Res. 60, 5879-5886.
21. Mazure, N.M., Chen, E.Y., Laderoute, K.R., and Giaccia, A.J. (1997) Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90, 3322-3331.
22. Mazure, N.M., Chen, E.Y., Yeh, P., Laderoute, K.R., and Giaccia, A.J. (1996) Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 56, 3436-3440.
23. Milanini, J., Vinals, F, Pouyssegur, J., and Pages, G. (1998) p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J. Biol. Chem. 273, 18165-18172.
24. Minet, E., Arnould, T., Michel, G., Roland, I., Mottet, D., Raes, M., Remacle, J., and Michiels, C. (2000) ERK activation upon hypoxia: Involvement in HIF-1 activation. FEBS Lett. 468, 53-58.
25. Pages, G., Milanini, J., Richard, D.E., Berra, E., Gothie, E., Vinals, F., and Pouyssegur, J. (2000) Signaling angiogenesis via p42/p44 MAP kinase cascade. Ann. N.Y. Acad. Sci. 902, 187-200.
26. Rak, J., Mitsuhashi, Y, Sheehan, C., Tamir, A., Viloria-Petit, A., Filmus, J., Mansour, S.J., Ahn, N.G., and Kerbel, R.S. (2000) Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor upregulation in ras-transformed epithelial cells and fibroblasts. Cancer Res. 60, 490-498.
27. Richard, D.E., Berra, E., Gothie, E., Roux, D., and Pouyssegur, J. (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274, 32631-32637.
28. Ryuto, M., Ono, M., Izumi, H., Yoshida, S., Welch, H.A., Kohno, K., and Kuwano, M. (1996) Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells: Possible roles of SP-1. J. Biol. Chem. 271, 28220-28228.
29. Sheta, E.A., Harding, M.A., Conaway, M.R., and Theodorescu, D. (2000) Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor. J. Natl. Cancer Inst. 92, 1065-1073.
30. Tsai, J.C., Goldman, C.K., and Gillespie, G.Y. (1995) Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF. J. Neurosurg. 82, 864-873.
31. Wang, D., Huang, H.J., Kazlauskas, A., and Cavenee, W.K. (1999) Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 59, 1464-1472.
32. Wang, G.L., Jiang, B.H., Rue, E.A., and Semenza, G.L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A. 92, 5510-5514.
33. Wang, G.L., and Semenza, G.L. (1993) Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 21513-21518.
34. Warren, R.S., Yuan, H., Matli, M.R., Ferrara, N., and Donner, D.B. (1996) induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J. Biol. Chem. 271, 29483-29488.
35. White, F.C., Benehacene, A., Scheele, J.S., and Kamps, M. (1997) VEGF mRNA is stabilized by ras and tyrosine kinase oncogenes, as well as by UV radiation-evidence for divergent stabilization pathways. Growth Factors 14, 199-212.
36. Wood, S.M., Gleadle, J.M., Pugh, C.W., Hankinson, O., and Ratcliffe, P.J. (1996) The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: Studies in ARNT-deficient cells. J. Biol. Chem. 271, 15117-15123.
37. Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M.M., Simons, J.W., and Semenza, G.L. (2000) Modulation of hypoxia-inducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 60, 1541-1545.
38. Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F, Chen, E., Gottschalk, A.R., Ryan, H.E., Johnson, R.S., Jefferson, A.B., Stokoe, D., and Giaccia, A.J. (2000) Loss of PTEN facilitates H1F-1-mediated gene expression. Genes Dev. 14, 391-396.