Internal initiation of translation by viral and cellular IRESs - A new avenue for specific inhibition of protein synthesis?

Current Opinion in Drug Discovery and Development

Volumn 5, Issue 5, 2002, Pages 777-784

  Gallego, José ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Cancer; Hepatitis C virus; Initiation; Internal ribosome entry site; Ribosome; Translation; Virus

Indexed keywords

ANTIVIRUS AGENT; INITIATION FACTOR; INITIATION FACTOR 4G; MESSENGER RNA; MYC PROTEIN;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; CANCER THERAPY; CARBOXY TERMINAL SEQUENCE; DNA VIRUS; ENCEPHALOMYOCARDITIS VIRUS; FOOT AND MOUTH DISEASE VIRUS; HEPATITIS A VIRUS; HEPATITIS C VIRUS; INTERNAL RIBOSOME ENTRY SITE; MITOSIS; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; ONCOGENE C MYC; PICORNAVIRUS; POLIOMYELITIS VIRUS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; RETROVIRUS; REVIEW; RHINOVIRUS; RIBOSOME; RNA STRUCTURE; RNA VIRUS; START CODON; TRANSLATION INITIATION; TRANSLATION REGULATION; VIRUS; VIRUS CAPSID; VIRUS TRANSCRIPTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; DNA VIRUSES; HUMANS; MOLECULAR CONFORMATION; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMES; RNA VIRUSES; RNA, MESSENGER;

EID: 0036771393     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

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