Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site

Journal of Molecular Biology

Volumn 319, Issue 1, 2002, Pages 1-8

  Takyar, Seyedtaghi S ^a,b   Gowans, Eric J ^a,b   Lott, William B ^a,b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Hepatitis C virus; Internal ribosome entry site; Toeprinting; Translation control; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; CYCLOHEXIMIDE; GUANYLYLIMIDODIPHOSPHATE;

ARTICLE; CENTRIFUGATION; COMPLEX FORMATION; CONTROLLED STUDY; HEPATITIS C; HEPATITIS C VIRUS; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; PRIORITY JOURNAL; SUCROSE GRADIENT; TRANSLATION INITIATION;

HEPATITIS C VIRUS;

EID: 0036306460     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00300-5     Document Type: Article

References (28)

1. Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus
2. Internal initiation of translation of hepatitis C virus RNA: The ribosome entry site is at the authentic initiation codon
3. Viral heterogeneity of the hepatitis C virus
4. Hepatitis C viral quasispecies
5. Variation of the hepatitis C virus 5′ non-coding region: Implications for secondary structure, virus detection and typing
6. Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs
7. Involvement of the 5′ proximal coding sequences of hepatitis C virus with internal initiation of viral translation
8. A phylogenetically conserved stem-loop structure at the 5′ border of the internal ribosome entry site of hepatitis C virus is required for cap-independent viral translation
9. Functional analysis of the interaction between HCV 5′UTR and putative subunits of eukaryotic translation initiation factor eIF3
10. Mutational analysis of a conserved tetraloop in the 5′ untranslated region of hepatitis C virus identifies a novel RNA element essential for the internal ribosome entry site function
11. Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES
12. Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA
13. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
14. The structure and function of initiation factors in eukaryotic protein synthesis
15. The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold
16. Vitamin B12 and hepatitis C: Molecular biology and human pathology
17. Initiation of protein synthesis from the A site of the ribosome
18. Primer extension analysis of eukaryotic ribosome-mRNA complexes
19. Ribosome pausing and stacking during translation of a eukaryotic mRNA
20. The pathway and mechanism of eukaryotic protein synthesis
21. Ribosome initiation complex formation with the pseudoknotted alpha operon messenger RNA
22. The joining of ribosomal subunits in eukaryotes requires eIF5B
23. Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition
24. Iron regulatory protein prevents binding of the 43 S translation preinitiation complex to ferritin and eALAS mRNAs
25. Kinetic dissection of fundamental processes of eukaryotic translation initiation in vitro
26. Translating ribosomes inhibit poliovirus negative-strand RNA synthesis
27. Iron regulatory proteins in pathobiology
28. In vitro selection of RNA aptamers specific for cyanocobalamin