Links between multiple chemical sensitivity and asthma in a rat model of cholinergic hypersensitivity: A brief review

Toxicology and Industrial Health

Volumn 15, Issue 5, 1999, Pages 517-521

  Overstreet, David H ^a   Djuric, Veljko ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLERGEN; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; DIAZEPAM; DOPAMINE RECEPTOR; MUSCARINIC AGENT; ORGANOPHOSPHATE PESTICIDE; SEROTONIN RECEPTOR;

ALLERGY; ASTHMA; BODY PLETHYSMOGRAPHY; BRONCHOSPASM; CHOLINERGIC SYSTEM; MULTIPLE CHEMICAL SENSITIVITY; NONHUMAN; SHORT SURVEY;

ANIMALS; ASTHMA; AUTONOMIC NERVOUS SYSTEM DISEASES; BRONCHIAL HYPERREACTIVITY; CHOLINERGIC FIBERS; DISEASE MODELS, ANIMAL; HUMANS; MULTIPLE CHEMICAL SENSITIVITY; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PARASYMPATHETIC NERVOUS SYSTEM; PLETHYSMOGRAPHY; RATS;

EID: 0033427716     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/074823379901500505     Document Type: Article

References (43)

1. Barnes P. J. Modulation of neurotransmission in airways. Physiol. Rev. 1992: 72: 699-729.
2. Chaudhuri A., Majeed T., Dinari T., and Behan P. O. Chronic fatigue syndrome: a disorder of central cholinergic transmission. J. Chronic Fatigue 1997: 3: 3-16.
3. Cone J. E., and Sult T. A. Acquired intolerance to solvents following pesticide/solvent exposure in a building: a new group of workers at risk for multiple chemical sensitivities? Toxicol. Ind. Health 1992: 8: 29-39.
4. Cox B., Kerwin R. W., Lee T. F., and Pycock C. J. A dopamine-5-hydroxytryptamine link in the hypothalamic pathways which mediate heat loss in the rat. J. Physiol. 1980: 303: 9-21.
5. Crocker A. D., and Overstreet D. H. Changes in dopamine sensitivity in rats selectively bred for differences in cholinergic function. Pharmacol. Biochem. Behav. 1991: 38: 105-108.
6. Daws L. C., and Overstreet D. H. Ontogeny of muscarinic cholinergic hypersensitivity in the Flinders Sensitive Line rat. Pharmacol. Biochem. Behav. 1999.
7. Daws L. C., Schiller G. D., Overstreet D. H., and Orbach J. Early development of muscarinic supersensitivity in a genetic animal model of depression. Neuropsychopharmacology 1991: 4: 207-217.
8. Djuric V. J., Overstreet D. H., Bienenstock J., and Perdue M. H. Immediate hypersensitivity in the Flinders rat: further evidence for a possible link between susceptibility to allergies and depression. Brain Behav. Immunol. 1995: 9: 196-206.
9. Djuric V. J., Cox G., Overstreet D. H., Smith L., Dragomir A., and Steiner M. Genetically transmitted cholinergic hyperresponsiveness predisposes to experimental asthma. Brain Behav. Immunol. 1998: 12: 272-284.
10. Fibiger H. C., Lytle L. D., and Campbell B. A. Cholinergic modulation of adrenergic arousal in the developing rat. J. Comp. Physiol. Psychol. 1970: 3: 384-389.
11. Janowsky D. S., Overstreet D. H., and Nurnberger J. I. Jr. Is cholinergic sensitivity a genetic marker for the affective disorders? Am. J. Med. Genet. Neuropsychiatr. Genet. 1994: 54: 335-344.
12. Klemm W. R. Drug effects on active immobility responses: what they tell us about neurotransmitter systems and motor function. Prog. Neurobiol. 1989: 32: 403-422.
13. Levy F. Clinical features of multiple chemical sensitivity. Scand. J. Work, Environ. Health 1997: 23 (suppl 3): 69-73.
14. Marshall P. S. Allergy and depression: a neurochemical threshold model of the relation between the illnesses. Psychol. Bull. 1993: 113: 23-43.
15. Meggs W. J., Dunn K. A., Bloch N. M., Goodman P. W., and Davidoff A. L. Prevalence and nature of allergy and chemical sensitivity in a general population. Arch. Environ. Health 1996: 51: 275-282.
16. Mesulam M.-M. Structure and function of cholinergic pathways in the cerebral cortex, limbic system, basal ganglia, and thalamus of the human brain. In: Bloom F. E., and Kupfer D. J. (Eds.), Neuropsychopharmacology. The Fourth Generation of Progress. Raven Press, New York, 1995, pp. 135–146.
17. Miller C. S., and Mitzel H. C. Chemical sensitivity attributed to pesticide exposure versus remodeling. Arch. Environ. Health 1995: 50: 119-129.
18. Overstreet D. H. Selective breeding for increased cholinergic function: development of a new animal model of depression. Biol. Psychiatry 1986: 21: 49-58.
19. Overstreet D. H. Correlations of ethanol-induced hypothermia in FSL and FRL rats with hypothermia induced by other drugs. Presented at 13th Annual Symposium of the North Carolina Alcoholism Research Authority, Raleigh, 1989.
20. Overstreet D. H. The Flinders Sensitive Line rats: a genetic animal model of depression. Neurosci. Biobehav. Rev. 1993: 17: 51-68.
21. Overstreet D. H., and Russell R. W. Selective breeding for sensitivity to DFP. Effects of cholinergic agonists and antagonists. Psychopharmacology 1982: 78: 150-154.
22. Overstreet D. H., Russell R. W., Helps S. C., and Messenger M. Selective breeding for sensitivity to the anticholinesterase, DFP. Psychopharmacology 1979: 65: 15-20.
23. Overstreet D. H., Russell R. W., Crocker A. D., and Schiller G. D. Selective breeding for differences in cholinergic function: pre- and post-synaptic mechanisms involved in sensitivity to the anticholinesterase, DFP. Brain Res. 1984: 294: 327-332.
24. Overstreet D. H., Double K., and Schiller G. D. Antidepressant effects of rolipram in a genetic animal model of depression: cholinergic supersensitivity and weight gain. Pharmacol. Biochem. Behav. 1989: 34: 691-696.
25. Overstreet D. H., Rezvani A. H., and Janowsky D. S. Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivity. Alcohol Alcohol. 1990: 25: 59-65.
26. Overstreet D. H., Rezvani A. H., and Janowsky D. S. Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. Biol. Psychiatry 1992: 31: 919-936.
27. Overstreet D. H., Janowsky D. S., Pucilowski O., and Rezvani A. H. Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross breeds of Flinders Line rats. Psychiatr. Genet. 1994: 4: 101-107.
28. Overstreet D. H., Pucilowski P., Rezvani A. H., and Janowsky D. S. Administration of antidepressants, diazepam, and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. Psychopharmacology 1995: 121: 27-37.
29. Overstreet D. H., Miller C. S., Janowsky D. S., and Russell R. W. Potential animal model of multiple chemical sensitivity with cholinergic supersensitivity. Toxicology 1996: 111: 119-134.
30. Overstreet D. H., Daws L. C., Schiller G. D., Orbach J., and Janowsky D. S. Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression. Pharmacol. Biochem. Behav. 1998: 59: 777-785.
31. Pepe S., Overstreet D. H., and Crocker A. D. Enhanced benzodiazepine responsiveness in rats with increased cholinergic function. Pharmacol. Biochem. Behav. 1988: 31: 15-20.
32. Pucilowski O. Monoaminergic control of affective aggression. Acta Neurobiol. Exp. 1987: 47: 25-50.
33. Pucilowski O., Eichelman B. S., Overstreet D. H., Rezvani A. H., and Janowsky D. S. Enhanced affective aggression in genetically bred hypercholinergic rats. Neuropsychobiology 1991: 24: 37-41.
34. Ray A., Sen P., and Alkondon M. Biochemical and pharmacological evidence for central cholinergic regulation of shock-induced aggression. Pharmacol. Biochem. Behav. 1989: 32: 867-871.
35. Rosenthal N., and Cameron C. L. Exaggerated sensitivity to an organophosphate pesticide (letter). Am. J. Psychiatry 1991: 148: 270-270.
36. Ross G. H. Clinical characteristics of chemical sensitivity, an illustrative case history of asthma and MCS. Environ. Health Perspect. 1997: 105 (suppl 2): 437-441.
37. Russell R. W., Overstreet D. H., Messenger M., and Helps S. C. Selective breeding for sensitivity to DFP. Generalization of effects beyond criterion variables. Pharmacol. Biochem. Behav. 1982: 17: 885-891.
38. Schiller G. D., and Overstreet D. H. Selective breeding for increased cholinergic function: preliminary study of nicotinic mechanisms. Med. Chem. Res. 1993: 2: 578-583.
39. Schiller G. D., Daws L. C., Overstreet D. H., and Orbach J. Absence of anxiety in an animal model of depression with cholinergic supersensitivity. Brain Res. Bull. 1991: 26: 443-447.
40. Tizabi Y., Overstreet D. H., Rezvani A. H., Luis V. A., Clark E. Jr., Janowsky D. S., and Kling M. A. Antidepressant effects of nicotine in an animal model of depression. Psychopharmacology 1999: 142: 193-199.
41. Wallis E., Overstreet D. H., and Crocker A. D. Selective breeding for increased cholinergic function: increased serotonergic sensitivity. Pharmacol. Biochem. Behav. 1988: 31: 345-350.
42. White A. M., Stevens W. H., Upton A. R., O'Byrne P. M., and Collins S. M. Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome. Gastroenterology 1991: 100: 69-74.
43. Ziem G., and McTanney J. Profile of patients with chemical injury and sensitivity. Environ. Health Perspect. 1997: 105 (suppl 2): 417-436.