Effect of levothyroxine administration on intestinal P-glycoprotein expression: Consequences for drug disposition

Clinical Pharmacology and Therapeutics

Volumn 72, Issue 3, 2002, Pages 256-264

  Siegmund, Werner ^a,b   Altmannsberger, Stephan ^a,b   Paneitz, Andrea ^a,b   Hecker, Ute ^a,b   Zschiesche, Michael ^a,b   Franke, Gerd ^a,b   Meng, Wieland ^a,b   Warzok, Rolf ^a,b   Schroeder, Eike ^a,b   Sperker, Bernhard ^a,b   Terhaag, Bernd ^a,b   Cascorbi, Ingolf ^a,b   Kroemer, Heyo K ^a,b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b Arzneimittelwerk Dresden GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC GLYCOSIDE; DIGOXIN; GLYCOPROTEIN P; LEVOTHYROXINE; MESSENGER RNA; TALINOLOL; THYROID HORMONE; THYROTROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG EFFECT; DUODENUM; FEMALE; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; HYPERTHYROIDISM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID FUNCTION;

ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; ADULT; AREA UNDER CURVE; DUODENUM; FEMALE; GENES, MDR; HUMANS; INJECTIONS, INTRAVENOUS; MALE; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PROPANOLAMINES; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; THYROXINE;

EID: 0036739659     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.126706     Document Type: Article

References (32)

1. Studies on digitalis; III: The influence of triiodothyronine on digitalis requirements
2. Clinical pharmacokinetics and endocrine disorders: Therapeutic implications
3. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
4. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein
5. Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
6. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
7. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
8. Functional polymorphism of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
9. The interaction of digoxin and rifampin: Role of intestinal P-glycoprotein
10. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
11. Effect of quinidine on digoxin bioavailability
12. Verapamil-induced changes in digoxin kinetics and intraerythrocytic sodium concentration
13. Longitudinal assessment of a P-glycoprotein-mediated drug interaction of valspodar on digoxin
14. Direct demonstration of small intestinal secretion and site-dependent absorption of the β-blocker talinolol in humans
15. Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil
16. Oral bioavailability of digoxin is enhanced by talinolol: Evidence for involvement of intestinal P-glycoprotein
17. Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction
18. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
19. Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans
20. 1-adrenoceptor antagonist talinolol in man
21. Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells
22. Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: Concentration- and dose-dependent absorption in vitro and in vivo
23. In vivo induction of liver P-glycoprotein expression by xenobiotics in monkeys
24. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
25. Modulation of P-glycoprotein expression by cytochrome P4503A inducers in male and female rat livers
26. The effect of rifampin treatment on intestinal expression of human MRP transporters
27. Nuclear response elements mediate induction of intestinal MDR1 by rifampin
28. Identification of functionally variant MDR1 alleles among European Americans and African Americans
29. MDR1 gene polymorphism and disposition of the P-glycoprotein substrate fexofenadine
30. Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
31. Markers of bone metabolism during short-term administration of thyroxine in healthy volunteers
32. Kinetic analysis of thyroid hormone action on glucose metabolism in man