Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in human epidermal keratinocytes

Toxicological Sciences

Volumn 69, Issue 1, 2002, Pages 226-233

  Chou, Chi Chung ^a   Riviere, Jim E ^a   Monteiro Riviere, Nancy A ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Aliphatic hydrocarbons; Cytotoxicity; Interleukin 8; Jet fuels; Keratinocytes

Indexed keywords

ALIPHATIC HYDROCARBON; CARBON; FUEL; INTERLEUKIN 8;

ARTICLE; CELL CULTURE; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; EPIDERMIS; EXPOSURE; HUMAN; HUMAN CELL; KERATINOCYTE; SKIN TOXICITY; STRUCTURE ACTIVITY RELATION; TIME; TOXICOLOGY;

AVIATION; CELL SURVIVAL; CELLS, CULTURED; EPIDERMIS; FUEL OILS; HUMANS; HYDROCARBONS; INTERLEUKIN-8; KERATINOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036737214     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.1.226     Document Type: Article

References (50)

1. Aggarwal, B. B., and Puri, K. J. (1995). Common and uncommon features of cytokines and cytokine receptors: An overview. In Human Cytokines: Their Role in Disease and Therapy (B. B. Aggarwal and K. J. Puri, Eds.), pp. 1-24. Blackwell, Oxford, U.K.
2. Allen, D. G., Riviere, J. E., and Monteiro-Riviere, N. A. (2000). Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100). J. Biochem. Mol. Toxicol. 14, 231-237.
3. Allen, D. G., Riviere, J. E., and Monteiro-Riviere, N. A. (2001a). Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: Delivery of hydrocarbons to cell cultures via complexation with α-cyclodextrin. Toxicol. In Vitro 15, 663-669.
4. Allen, D. G., Riviere, J. E., and Monteiro-Riviere, N. A. (2001b). Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes. Toxicol. Lett. 119, 209-217.
5. Arbabi S., and Maier R. V. (2002). Mitogen-activated protein kinases. Crit. Care Med. 30, S74-79.
6. Basak, S. C., Gute, B. D., Grunweld, D., Mills, D., and Riviere, J. E. (2000). Clustering of JP-8 Chemicals Using Sturture Spaces and Property Spaces. A Computational Approach. JP-8 Toxicology Workshop, Tucson, AZ.
7. Baxter, C. S., and Miller, M. L. (1987). Mechanism of mouse skin tumor promotion by n-dodecane. Carcinogenesis 8, 1787-1790.
8. Baynes, R. E., Brooks, J. D., Budsaba, K., Smith, C. E., and Riviere, J. E. (2001). Mixture effects of JP-8 additives on the dermal disposition of jet fuel components. Toxicol. Appl. Pharmacol. 175, 269-281.
9. Baynes, R. E., Brooks, J. D., and Riviere, J. E. (2000). Membrane transport of naphthalene and dodecane in jet fuel mixtures. Toxicol. Indust. Health 16, 225-238.
10. Borenfreund, E., and Puerner, J. A. (1985). Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 24, 119-124.
11. Broddle, W. D., Dennis, M. W., Kitchen, D. N., and Vernot, E. H. (1996). Chronic dermal studies of petroleum streams in mice. Fundam. Appl. Toxicol. 30, 47-54.
12. Brown, V. K., and Box, V. L. (1970). Skin arginase activity as a measure of skin change under the influence of some alkanes and alkenes. Br. J. Dermatol. 82, 606-612.
13. Bruch-Gerharz D., Fehsel K., Suschek C., Michel G., Ruzicka T., and Kolb-Bachofen V. (1996). A proinflammatory activity of interleukin 8 in human skin: Expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J. Exp. Med. 184, 2007-2012.
14. Cavaillon, J. M. (2001). Pro- versus anti-inflammatory cytokines: Myth or reality. Cell. Mol. Biol. 47, 695-702.
15. Clydesdale, G. J., Dandie, G. W., and Muller, H. K. (2001). Ultraviolet light induced injury: Immunological and inflammatory effects. Immunol. Cell Biol. 79, 547-568.
16. Committee on Toxicology. (1996). Permissible Exposure Levels for Selected Military Fuel Vapors. National Academy Press, Washington, DC.
17. Corsini E., and Galli, C. L. (2000). Epidermal cytokines in experimental contact dermatitis. Toxicology 142, 203-211.
18. Cruz, M. T., Duarte, C. B., Goncalo, M., Figueiredo, A., Carvalho, A. P., and Lopes, M. C. (2001). Granulocyte-macrophage colony-stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line. Immunol. Cell Biol. 79, 590-596.
19. Dudley, A. C., Peden-Adams, M. M., EuDaly, J., Pollenz, R. S., and Keil, D. E. (2001). An aryl hydrocarbon receptor independent mechanism of JP-8 jet fuel immunotoxicity in Ah-responsive and Ah-nonresponsive mice. Toxicol. Sci. 59, 251-259.
20. Dugard, P. H., and Scott, R. C. (1984). Absorption through the skin. In Chemotherapy of Psoriasis (H. P. Baden, Ed.), pp. 125-144. Pergamon Press, Oxford, U.K.
21. Effendy, I., Loffler, H., and Maibach, H. I. (2000). Epidermal cytokines in murine cutaneous irritant responses. J. Appl. Toxicol. 20, 335-341.
22. Enslein, K., Borgstedt, H. H., Blake, B. W., and Hart, J. B. (1987). Prediction of rabbit skin irritation severity by structure-activity relationships. In Vitro Toxicol. 1, 129-147.
23. Farkas, A., Kemeny, L., Szony, B. J., Bata-Csorgo, Z., Pivarcsi, A., Kiss, M., Szell, M., Koreck, A., and Dobozy, A. (2001). Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT. Inflamm. Res. 50, 44-49.
24. Feghali, C. A., and Wright, T. M. (1997). Cytokines in acute and chronic inflammation. Front. in Biosci. 2, d12-26.
25. Flynn, G. L. (1990). Physicochemical determinants of skin absorption. In Principles of Route-to-Route Extrapolation for Risk Assessment (T. R. Gerrity and C. J. Henry, Eds.), pp. 93-127. Elsevier Science Publishing, New York.
26. Freeman, J. J., Federici, T. M., and McKee, R. H. (1993). Evaluation of the contribution of chronic skin irritation and selected compositional parameters to the tumorigenicity of petroleum middle distillates in mouse skin. Toxicology 81, 103-112.
27. Freeman, J. J., McKee, R. H., Phillips, R. D., Plutnick, R. T., Scala, R. A., and Ackerman, L. J. (1990). A 90-day toxicity study of the effects of petroleum middle distillates on the skin of C3H mice. Toxicol. Ind. Health 6, 475-491.
28. Geiss, K. T., and Frazier, J. M. (2001). In vitro toxicities of experimental jet fuel system ice-inhibiting agents. Sci. Total Environ. 274, 209-218.
29. Grant, G. M., Shaffer, K. M., Kao, W. Y., Stenger, D. A., and Pancrazio, J. J. (2000). Investigation of in vitro toxicity of jet fuels JP-8 and Jet A. Drug Chem. Toxicol. 23, 279-291.
30. Harris, D. T., Sakiestewa, D., Robledo, R. F., Young, R. S., and Witten, M. (2000). Effects of short-term JP-8 jet fuel exposure on cell-mediated immunity. Toxicol. Ind. Health 16, 78-84.
31. Kabbur, M. B., Rogers, J. V., Gunasekar, P. G., Garrett, C. M., Geiss, K. T., Brinkley, W. W., and McDougal, J. N. (2001). Effect of JP-8 jet fuel on molecular and histological parameters related to acute skin irritation. Toxicol. Appl. Pharmacol. 175, 83-88.
32. Kemeny, L., Ruzicka, T., Dobozy, A., and Michel, G. (1994). Role of interleukin-8 receptor in skin. Int. Arch. Allerg. Immunol. 104, 317-322.
33. McDougal, J. N., Pollard, D. L., Weisman, W., Garrett, C. M., and Miller, T. E. (2000). Assessment of skin absorption and penetration of JP-8 jet fuel and its components. Toxicol. Sci. 55, 247-255.
34. Monteiro-Riviere, N., Inman, A., and Riviere, J. (2001). Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels. J. Appl. Toxicol. 21, 485-494.
35. Moody, D. B., Besra, G. S., Wilson, I. A., and Porcelli, S. A. (1999). The molecular basis of CD1-mediated presentation of lipid antigens. Immunol. Rev. 172, 285-296.
36. Nickoloff, B. J. (1991). The cytokine network in psoriasis. Arch Dermatol. 127, 871-884.
37. Oberholzer, A., Oberholzer, C., and Moldawer, L. L. (2002). Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit. Care Med. 30(Suppl. 1), S58-63.
38. Reich, K., Garbe, C., Blaschke, V., Maurer, C., Middel, P., Westphal, G., Lippert, U., and Neumann, C. (2001). Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway, and normalization of keratinocyte maturation. J. Invest. Dermatol. 116, 319-329.
39. Rhyne, B. N., Pirone, J. R., Riviere, J. E., and Monteiro-Riviere, N. A. (2002). The use of enzyme histochemistry in detecting cutaneous toxicity of three topically applied jet fuel mixtures. Toxicol. Mech. Methods 12, 17-24.
40. Riviere, J. E., Brooks, J. D., Monteiro-Riviere, N. A., Budsaba, K., and Smith, C. E. (1999). Dermal absorption and distribution of topically dosed jet fuels Jet-A, JP-8, and JP-8(100). Toxicol. Appl. Pharmacol. 160, 60-75.
41. Rosenthal, D. S., Simbulan-Rosenthal, C. M., Liu, W. F., Stoica, B. A., and Smulson, M. E. (2001). Mechanisms of JP-8 jet fuel cell toxicity: II. Induction of necrosis in skin fibroblasts and keratinocytes and modulation of levels of Bcl-2 family members. Toxicol. Appl. Pharmacol. 171, 107-116.
42. Scheuplein, R. J., and Blank, I. H. (1971). Permeability of the skin. Physiol. Rev. 51, 702-747.
43. Senftleben, U., and Karin, M. (2002). The INK/NF-κB pathway. Crit. Care Med. 30(Suppl. 1), S18-26.
44. Sice, J. (1966). Tumor-promoting activity on n-alkanes and 1-alkanols. Toxicol. Appl. Pharmacol. 9, 70-74.
45. Takashima, A., and Bergstresser, P. R. (1996). Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells. Semin. Immunol. 8, 333-339.
46. Takizawa, H., Ohtoshi, T., Kawasaki, S., Abe, S., Sugawara, I., Nakahara, K., Matsushima, K., and Kudoh, S. (2000). Diesel exhaust particles activate human bronchial epithelial cells to express inflammatory mediators in the airways: A review. Respirology 5, 197-203.
47. Terunuma, A., Aiba, S., and Tagami, H. (2001). Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: A simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J. Dermatol. Sci. 26, 85-93.
48. Ullrich, S. E. (1999). Dermal application of JP-8 jet fuel induces immune suppression. Toxicol. Sci. 52, 61-67.
49. Ullrich, S. E., and Lyons, H. J. (2000). Mechanisms involved in the immunotoxicity induced by dermal application of JP-8 jet fuel. Toxicol. Sci. 58, 290-298.
50. Valacchi, G., Rimbach, G., Saliou, C., Weber, S. U., and Packer, L. (2001). Effect of benzoyl peroxide on antioxidant status, NF-κB activity, and interleukin-1a gene expression in human keratinocytes. Toxicology 165, 225-234.