Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: A simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant

Journal of Dermatological Science

Volumn 26, Issue 2, 2001, Pages 85-93

  Terunuma, Atsushi ^a   Aiba, Setsuya ^a   Tagami, Hachiro ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytokine profile; Detergent; Endothelial cell; Fibroblast; Keratinocyte; Stripping

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; CYTOKINE; DODECYL SULFATE SODIUM; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HAPTEN; HYDROGEN PEROXIDE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; IRRITANT AGENT; MESSENGER RNA; NICKEL CHLORIDE; SODIUM CHLORIDE;

ARTICLE; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; KERATINOCYTE; NEWBORN; OSMOSIS; PRIORITY JOURNAL; SKIN CELL; SKIN FIBROBLAST; SKIN IRRITATION; SKIN SURFACE; STRATUM CORNEUM;

CELLS, CULTURED; CYTOKINES; HAPTENS; HUMANS; IRRITANTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; UP-REGULATION;

EID: 0034982524     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(00)00165-1     Document Type: Article

References (11)

1. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin
2. Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption
3. Barrier function coordinately regulates epidermal IL-1 and IL-1 receptor antagonist mRNA levels
4. Barrier disruption increases gene expression of cytokines and the 55 kD TNF receptor in murine skin
5. Hyperosmotic stress as a stimulant for proinflammatory cytokine production
6. Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro
7. Keratinocytes interleukin-10 expression is upregulated in tape-stripped skin, poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques
8. CD11b+ macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein
9. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules
10. Identification and induction of keratinocyte-derived IL-10
11. Effects of contact sensitizers neomycin sulfate, benzocaine and 2,4-dinitrobenzene 1-sulfonate, sodium salt on viability, membrane integrity and IL-1 alpha mRNA expression of cultured normal human keratinocytes