Effects of the diacylglycerol complexing agent, cremophor, on nerve- conduction velocity and perfusion in diabetic rats

Journal of Diabetes and its Complications

Volumn 13, Issue 1, 1999, Pages 2-9

  Jack, Alison M ^a   Cameron, Norman E ^a   Cotter, Mary A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREMOPHOR; DIACYLGLYCEROL; FLURBIPROFEN; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; ENDONEURIUM; ENZYME ACTIVATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE CONDUCTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SAPHENOUS NERVE; SCIATIC NERVE; STREPTOZOCIN DIABETES; TISSUE PERFUSION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; DIGLYCERIDES; MALE; MOTOR NEURONS; NERVE FIBERS; NEURAL CONDUCTION; NEURONS, AFFERENT; PERIPHERAL NERVES; PHOSPHOLIPASE C; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE;

EID: 0032964936     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8727(98)00014-2     Document Type: Article

References (64)

1. Greene D.A., Sima A.A.F., Stevens M.J., Feldman E.L., Lattimer S.A. Complications. Neuropathy, pathogenic considerations Diabetes Care. 15:1992;1902-1925.
2. Shiba T., Inoguchi T., Sportsman J.R., Heath W.F., Bursell S., King G.L. Correlation of diacylglycerol level and protein kinase C activity in the rat retina to retinal circulation. Am J Physiol. 265:1993;E783-E793.
3. Studer R.K., Craven P.A., DeRubertis F.R. Antioxidant inhibition of protein kinase C signaled increases in transforming growth factor-beta in mesangial cells. Metabolism. 46:1997;918-925.
4. Koya D., Jirousek M.R., Lin Y.W., Ishii H., Kuboki K., King G.L. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 100:1997;115-126.
5. Cohen R.A. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 87(suppl V):1993;V67-V76.
6. Kunisaki M., Bursell S., Umeda F., Nawata H., King G.L. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 43:1994;1372-1377.
7. Ishii H., Jirousek M.R., Koya D., Takagi C., Xia P., Clermont A., Bursell S.-E., Kern T.S., Ballas L.M., Heath W.F., Stramm L.E., Feener E.P., King G.L. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor. Science. 272:1996;728-731.
8. Kim J., Rushovich E.H., Thomas T.P., Ueda T., Agranoff B.W., Greene D.A. Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-diabetic rats and its correction by dietary myo-inositol. Diabetes. 40:1991;1545-1554.
9. Borghini I., Ania-Lahuerta A., Regazzi R., Ferrari G., Gjinovci A., Wollheim C.B., Pralong W.-F. α, βI, βII, δ, and ε protein kinase C isoforms and compound activity in the sciatic nerve of normal and diabetic rats. J Neurochem. 62:1994;686-696.
10. Mathew J., Bianchi R., McLean W.G., Peterson R.G., Roberts R.E., Savaresi S., Eichberg J. Phosphoinositide metabolism, Na,K-ATPase and protein kinase C are altered in peripheral nerve from Zucker diabetic fatty rats (ZDF/Gmi-f alpha). Neurosci Res Commun. 20:1997;21-30.
11. Low P.A., Lagerlund T.D., McManis P.G. Nerve blood flow and oxygen delivery in normal, diabetic and ischemic neuropathy. Int Rev Neurobiol. 31:1989;355-438.
12. Cameron N.E., Cotter M.A. The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications. Diabetes Metab Rev. 10:1994;189-204.
13. Tesfaye S., Malik R., Ward J.D. Vascular factors in diabetic neuropathy. Diabetologia. 37:1994;847-854.
14. Pelligrino D.A., Koenig H.M., Wang Q., Albrecht R.F. Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat. Neuroreport. 5:1994;417-420.
15. Mayhan W.G., Patel K.P. Acute effects of glucose on reactivity of cerebral microcirculation. Role of activation of protein kinase C Am J Physiol. 269:1995;H1297-H1302.
16. Zhao F.-K., Chuang L.F., Israel M., Chuang R.Y. Cremophor EL, a widely used parenteral vehicle, is a potent inhibitor of protein kinase C. Biochem Biophys Res Commun. 159:1989;1359-1367.
17. Cameron N.E., Cotter M.A., Dines K.C., Maxfield E.K. Pharmacological manipulation of vascular endothelium in non-diabetic and streptozotocin-diabetic rats. Effects on nerve conduction, hypoxic resistance and endoneurial capillarization Diabetologia. 36:1993;516-522.
18. Cameron N.E., Cotter M.A., Dines K.C., Robertson S., Cox D. The effects of evening primrose oil on peripheral nerve function and capillarization in streptozotocin-diabetic rats. Modulation by the cyclo-oxygenase inhibitor flurbiprofen Br J Pharmacol. 109:1993;972-979.
19. Cameron N.E., Cotter M.A., Hohman T.C. Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. Diabetologia. 39:1996;172-182.
20. Cameron N.E., Cotter M.A. Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM15.0639, in diabetic rats. Naunyn Schmeidebergs Arch Pharmacol. 352:1995;685-690.
21. Cameron N.E., Cotter M.A., Low P.A. Nerve blood flow in early experimental diabetes in rats. Relation to conduction deficits Am J Physiol. 261:1991;E1-E8.
22. Cameron N.E., Cotter M.A., Robertson S. The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. Q J Exp Physiol. 74:1989;917-926.
23. Cameron N.E., Cotter M.A., Basso M., Hohman T.C. Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. Diabetologia. 40:1997;271-281.
24. 2 clearance curves used to measure blood flow in rat sciatic nerve. J Physiol. 414:1989;35-54.
25. 2. J Clin Invest. 96:1995;733-740.
26. +-ATPase activity and vascular supply in STZ-D rats. Diabetes. 40:1991;1652-1658.
27. Xia P., Inoguchi T., Kern T.S., Engerman R.L., Oates P.J., King G.L. Characterization of the mechanism for the chronic activation of DAG-PKC pathway in diabetes and hypergalactosemia. Diabetes. 43:1994;1122-1129.
28. Dines K.C., Cotter M.A., Cameron N.E. Nerve function in galactosaemic rats. Effects of evening primrose oil and doxazosin Eur J Pharmacol. 281:1995;303-309.
29. Love A., Cotter M.A., Cameron N.E. Nerve function and regeneration in diabetic and galactosaemic rats. Antioxidant and metal chelator effects Eur J Pharmacol. 314:1996;33-39.
30. Lambourne J.E., Brown A.M., Calcutt N., Tomlinson D.R., Willars G.B. Adenosine triphosphatase in nerves and ganglia of rats with streptozotocin-induced diabetes or galactosaemia; effects of aldose reductase inhibition. Diabetologia. 31:1988;379-384.
31. +)-ATPase activity in galactose intoxication. Metabolism. 40:1991;1207-1212.
32. Yagihashi S. Pathology and pathogenetic mechanisms of diabetic neuropathy. Diabetes Metab Rev. 11:1995;193-225.
33. Cameron N.E., Cotter M.A. Rapid reversal by aminoguanidine of the neurovascular effects of diabetes in rats. Modulation by nitric oxide synthase inhibition Metabolism. 45:1996;1147-1152.
34. Cameron N.E., Cotter M.A., Jack A., Hohman T.C. Inhibition of protein kinase C corrects nerve conduction and blood flow deficits in diabetic rats. Diabetologia. 40(suppl 1):1997;A31.
35. Cameron N.E., Cotter M.A. Neurovascular effects of L-carnitine treatment in diabetic rats. Eur J Pharmacol. 319:1997;239-244.
36. 1 adrenoceptor antagonist treatment. interactions with the nitric oxide system Eur J Pharmacol. 343:1998;217-223.
37. Ward K.K., Low P.A., Schmelzer J.D., Zochodne D.W. Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats. Brain. 112:1989;197-208.
38. 1 modifies nerve conduction and interferes with local anaesthetic action. Prostaglandins. 14:1977;103-108.
39. Stevens E.J., Carrington A.L., Tomlinson D.R. Prostacyclin release in experimental diabetes. effects of evening primrose oil Prostaglandins Leukot Essent Fatty Acids. 49:1993;699-706.
40. 2) synthesis by aortic rings from rats with streptozotocin-induced diabetes. Prostaglandins Leukot Essent Fatty Acids. 44:1991;233-236.
41. Cameron N.E., Cotter M.A., Dines K.C., Maxfield E.K., Carey F., Mirrlees D.J. Aldose reductase inhibition, nerve perfusion oxygenation and function in streptozotocin-diabetic rats. Dose-response considerations and independence from a myo-inositol mechanism Diabetologia. 37:1994;651-653.
42. Cameron N.E., Cotter M.A. Mechanisms underlying impaired peripheral nerve perfusion and endoneurial oxygenation in experimental diabetes. potential treatment strategies Hotta N., Greene D.A., Ward J.D., Sima A.A.F., Boulton A.J.M. Diabetic Neuropathy. New Concepts and Insights:1995;3-15 Elsevier, Amsterdam.
43. Kamata K., Chikada S., Umeda F., Kasuya Y. Effects of phorbol ester on vasodilation induced by endothelium-dependent or endothelium-independent vasodilators in the mesenteric arterial bed. J Cardiovasc Pharmacol. 26:1995;645-652.
44. Hirata K., Kuroda R., Sakoda T., Katayama M., Inoue N., Suematsu M., Kawashima S., Yokoyama M. Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Hypertension. 25:1995;180-185.
45. Ohara Y., Sayegh H.S., Yamin J.J., Harrison D.G. Regulation of endothelial constitutive nitric oxide synthase by protein kinase. C. Hypertension. 25:1995;415-420.
46. Kihara M., Low P.A. Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol. 132:1995;180-185.
47. Maxfield E.K., Cameron N.E., Cotter M.A. Effect of diabetes on reactivity of sciatic vasa nervorum in rats. J Diabet Complications. 11:1996;47-55.
48. Shimamoto Y., Shimamoto H., Kwan C., Daniel E.E. Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle. Am J Physiol. 264:1994;H1300-H1306.
49. Rubanyi G.M., Polokoff M.A. Endothelins. Molecular biology, biochemistry, pharmacology, physiology and pathophysiology Pharmacol Rev. 46:1994;325-415.
50. Takada Y., Miyamori I., Yoneda T., Takeda R. Production of endothelin-1 from the mesenteric arteries of streptozotocin-induced diabetic rats. Life Sci. 48:1991;2553-2556.
51. A antagonist on neurovascular function in diabetic rats. Interaction with the renin-angiotensin system J Pharmacol Exp Ther. 278:1996;1262-1268.
52. Numaguchi K., Shimokawa H., Nakaike R., Egashira K., Takeshita A. PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats. Am J Physiol. 270:1996;H1634-H1639.
53. Keegan A., Walbank H., Cotter M.A., Cameron N.E. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta. Diabetologia. 38:1995;1475-1478.
54. Rösen P., Ballhausen T., Bloch W., Addicks K. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart. influence of tocopherol as antioxidant Diabetologia. 38:1995;1157-1168.
55. Cotter M.A., Love A., Watt M.J., Cameron N.E., Dines K.C. Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats. Diabetologia. 38:1995;1285-1294.
56. Karasu C., Dewhurst M., Stevens E.J., Tomlinson D. Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids. Diabetologia. 38:1995;129-134.
57. Cameron N.E., Cotter M.A. Neurovascular dysfunction in diabetic rats. potential contribution of autoxidation and free radicals examined using transition metal chelating agents J Clin Invest. 96:1995;1159-1163.
58. Nagamatsu M., Nickander K.K., Schmelzer J.D., Raya A., Wittrock A., Tritschler H., Low P.A. Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 18:1995;1160-1167.
59. Hohman T.C., Banas D., Basso M., Cotter M.A., Cameron N.E. Increased oxidative stress in experimental diabetic neuropathy. Diabetoligia. 40(suppl 1):1997;A549.
60. Cameron N.E., Cotter M.A., Dines K.C., Hohman T.C. Reversal of defective peripheral nerve conduction velocity, nutritive endoneurial blood flow and oxygenation by a novel aldose reductase inhibitor, WAY-121,509, in streptozotocin-diabetic rats. J Diabet Complications. 10:1996;43-53.
61. Kihara M., Zollman P.J., Smithson I.L., Lagerlund T.D., Low P.A. Hypoxic effect of exogenous insulin on normal and diabetic peripheral nerve. Am J Physiol. 266:1994;E980-E985.
62. Cotter M.A., Cameron N.E. Effects of dietary supplementation with arachidonic acid rich oils on nerve conduction and blood flow in streptozotocin-diabetic rats. Prostaglandins Leukot Essent Fatty Acids. 56:1997;337-343.
63. Inoguchi T., Xia P., Kunisaki M., Higashi S., Feener E.P., King G.L. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 267:1994;E369-E379.
64. Rao K.V.R., Vaidyanathan V.V., Sastry P.S. Diacylglycerol kinase is stimulated by arachidonic acid in neural membranes. J Neurochem. 63:1994;1454-1459.