SHP-1 regulates Fcγ receptor-mediated phagocytosis and the activation of RAC

Blood

Volumn 100, Issue 5, 2002, Pages 1852-1859

  Kant, Anita M ^a,b,c,d   De, Pradip ^a,b,c,d   Peng, Xiaodong ^a,b,c,d   Yi, Taolin ^a,b,c,d   Rawlings, David J ^a,b,c,d   Kim, Jong Suk ^a,b,c,d   Durden, Donald L ^a,b,c,d  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; CRK LIKE PROTEIN; FC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RAC PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ERYTHROCYTE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SHEEP; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MICE; PHAGOCYTOSIS; PROTEIN-TYROSINE-PHOSPHATASE; RAC GTP-BINDING PROTEINS; RECEPTORS, IGG; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0036721029     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. The Fc gamma RI receptor signals through the activation of hck and MAP kinase
2. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn
3. Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling
4. Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase
5. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
6. Ras-related GTP-binding proteins and leukocyte signal transduction
7. Induction of phagocytosis by a protein tyrosine kinase
8. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages
9. Clustered syk tyrosine kinase domains trigger phagocytosis
10. Fc receptors
11. Fc receptor biology
12. Identification, molecular cloning, biologic properties, and tissue distribution of a novel isoform of murine low-affinity IgG receptor homologous to human Fc gamma RIIB1
13. Structure of the mouse beta Fc gamma receptor II gene
14. Immunoreceptor tyrosine-based inhibition motifs
15. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation
16. Recruitment and activation of PTP1C In negative regulation of antigen receptor signaling by Fc gamma RiiB1
17. The killer cell inhibitory receptor genomic region on human chromosome 19q 13.4
18. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
19. Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell
20. The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling
21. Modulation of immune complex-induced inflammation In vivo by the coordinate expression of activation and inhibitory Fc receptors
22. Differential functions of the two Src homology 2 domains In protein tyrosine phosphatase SH-PTP1
23. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
24. Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1
25. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis
26. Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells
27. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
28. Phosphotyrosine 1173 mediates binding of the protein-tyroslne phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling
29. Protein tyrosine phosphatase 1 C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
30. Role of the inosltol phosphatase SHIP in negative regulation of the immune system by the receptor Fc-(gamma)RIIB
31. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
32. Hematopoiefic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells
33. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering
34. PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac
35. A role for Shc, Grb2, and Raf-1 in FcgammaRI signal relay
36. CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling
37. Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors
38. Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)
39. Deficiency of the hematopoletic cell-specific Rho family GTPase Rac2 is characterized by abnormalities In neutrophil function and host defense
40. Syk kinase, tyrosine-phosphorylated proteins and actin filaments accumulate at forming phagosomes during Fcgamma receptor-mediated phagocytosis
41. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
42. The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation
43. Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides
44. Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling
45. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
46. Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fc gamma receptor signaling
47. Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways
48. The product of the protooncogene c-cbl: A negative regulator of the Syk tyrosine kinase
49. Enhancement of Fcgamma receptor-mediated phagocytosis by transforming mutants of Cbl
50. SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling
51. Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1
52. SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling
53. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors