A label-free optical technique for detecting small molecule interactions

Biosensors and Bioelectronics

Volumn 17, Issue 9, 2002, Pages 827-834

  Lin, Bo ^a   Qiu, Jean ^a   Gerstenmeier, John ^a   Li, Peter ^a   Pien, Homer ^a   Pepper, Jane ^a   Cunningham, Brian ^a  

^a SRU Biosystems   (United States)

Author keywords

Direct assay; High throughput screening; Microtiter plate; Optical biosensor; Resonant diffraction; Small molecule assay

Indexed keywords

COLORIMETRY; DIFFRACTION GRATINGS; ENZYMES; FLUORESCENCE; GLASS; RADIOACTIVE MATERIALS; SUBSTRATES;

MOLECULAR INTERACTIONS;

BIOSENSORS;

4 NITROANILINE; AVIDIN; BIOTIN; PROTEINASE;

ARTICLE; BINDING AFFINITY; BIOSENSOR; ENZYME ASSAY; FLUORESCENCE; GRATING; MICROTITER PLATE ASSAY; MOLECULAR INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SCREENING TEST;

AVIDIN; BIOSENSING TECHNIQUES; BIOTIN; CASPASE 3; CASPASES; COLORIMETRY; ENZYME ACTIVATION; ENZYMES, IMMOBILIZED; MACROMOLECULAR SUBSTANCES; OPTICS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS; SUBSTRATE SPECIFICITY; TITRIMETRY;

EID: 0036715413     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0956-5663(02)00077-5     Document Type: Article

References (17)

1. Label-free observation of DNA-hybridisation and endonuclease activity on a waveguide surface using a grating coupler
2. Optical probes and transducers
3. Colormetric resonant reflection as a direct biochemical assay technique
4. A plastic colorimetric resonant optical biosensor for multiparallel detection of label-free biochemical interactions
5. Antibody arrays for high-throughput screening of antibody-antigen interactions
6. Direct optical immunosensing (sensitivity and selectivity)
7. Interference-based detection of nucleic acid targets on optically coated silicon
8. A biosensor concept based on imaging ellipsometry for visualization of biomolecular interactions
9. Surface plasmon resonance imaging measurements of electrostatic biopolymer adsorption onto chemically modified gold surfaces
10. Proteomics: Applications in basic and applied biology
11. A porous silicon-based optical interferometric biosensor
12. Printing proteins as microarrays for high-throughput function determination
13. Immobilization of antibodies in micropatterns for cell detection by optical diffraction
14. Proteomics to study genes and genomes
15. Proteomics: The industrialization of protein chemistry