Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer

Clinical Cancer Research

Volumn 8, Issue 9, 2002, Pages 2890-2893

  Yang, Qifeng ^a   Nakamura, Misa ^a   Nakamura, Yasushi ^a   Yoshimura, Goro ^a   Suzuma, Takaomi ^a   Umemura, Teiji ^a   Shimizu, Yukio ^a   Mori, Ichiro ^a   Sakurai, Takeo ^a   Kakudo, Kennichi ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; MICROSATELLITE DNA;

5' UNTRANSLATED REGION; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER INVASION; CHROMOSOME 3P; CLINICAL ARTICLE; CPG ISLAND; DNA METHYLATION; GENE INACTIVATION; GENE SILENCING; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 3; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS);

EID: 0036715315     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

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4. Deletion of two separate regions on chromosome 3p in breast cancers
5. At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma
6. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
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