Regulation of chemokine expression by cyclosporine a in alveolar macrophages exposed to hypoxia and reoxygenation

Annals of Thoracic Surgery

Volumn 74, Issue 3, 2002, Pages 899-905

  Naidu, Babu V ^a   Krishnadasan, Baiya ^a   Byrne, Karen ^a   Farr, Angie L ^a   Rosengart, Matthew ^a   Verrier, Edward D ^a   Mulligan, Michael S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYCLOSPORIN A; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR PROTEIN; PROTEIN INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL HYPOXIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTROPHORETIC MOBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RAT; REOXYGENATION; RNA TRANSCRIPTION;

ANIMALS; CELL HYPOXIA; CHEMOKINES; CYCLOSPORINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; LUNG; MACROPHAGES, ALVEOLAR; MALE; PREMEDICATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 0036711654     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(02)03746-3     Document Type: Article

References (27)

1. Lung transplantation: A decade of experience
2. Pattern of injury and the role of neutrophils in reperfusion injury of rat lung
3. Mediators of ischemia-reperfusion injury of rat lung
4. Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat
5. Requirement for C-X-C chemokines (macrophage inflammatory protein-2, and cytokine-induced neutrophil chemoattractant) in IgG immune complex-induced lung injury
6. Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB
7. Mechanisms of action of cyclosporine
8. NF-κB: Ten years later
9. Preoperative cyclosporine and tacrolimus decrease lung ischemia-reperfusion injury in rats
10. An essential role for NF-kappaB in the cardioadaptive response to ischemia
11. Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-kappaB expression
12. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin
13. Requirement for C-X-C chemokines (macrophage inflammatory protein-2, and cytokine-induced neutrophil chemoattractant) in IgG immune complex-induced lung injury
14. Regulation of macrophage inflammatory protein-1alpha mRNA by oxidative stress
15. Adhesion and pollution particle-induced oxidant generation is neither necessary nor sufficient for cytokine induction in human alveolar macrophages
16. Adherence regulates macrophage signal transduction and primes tumor necrosis factor production
17. Effect of cyclosporin A on inflammatory cytokine production by an alveolar macrophages
18. Cytokine profile of human bronchoalveolar macrophages and bronchial epithelial cells in response to inhalation particles of the cyclosporine derivative IMM 125
19. Combination therapy of cyclosporine with steroid inhibits gamma-interferon and interleukin-1 gene expression at the level of mRNA synthesis in vivo
20. The in vivo effect of cyclosporine A on macrophages
21. Cyclosporine A is an uncompetitive inhibitor of protease activity and prevents NF-kappaB activation
22. Peroxynitrite formed by simultaneous nitric oxide and superoxide generation causes cyclosporin-A-sensitive mitochondrial calcium efflux and depolarisation
23. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
24. Differential anti-inflammatory effects of immunosuppressive drugs: Cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production
25. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
26. Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response