Cortisol metabolism in healthy young adults: Sexual dimorphism in activities of A-ring reductases, but not 11β-hydroxysteroid dehydrogenases

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 9, 1999, Pages 3316-3321

  Finken, M J J ^a   Andrews, R C ^a   Andrew, R ^a   Walker, B R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; CORTISONE; DEXAMETHASONE; ESTRADIOL; HYDROCORTISONE; HYDROCORTISONE DERIVATIVE; STEROID 5ALPHA REDUCTASE; STEROID 5BETA REDUCTASE; TETRAHYDROCORTISONE;

ADULT; ANDROGEN METABOLISM; ARTICLE; BODY FAT; DOWN REGULATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME REACTIVATION; FEMALE; FIRST PASS EFFECT; FOLLICULAR PHASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE URINE LEVEL; INSULIN SENSITIVITY; LUTEAL PHASE; MALE; MENSTRUAL CYCLE; METABOLITE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE; STEROID METABOLISM; URINARY EXCRETION;

RODENTIA;

EID: 0033304506     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.9.6009     Document Type: Article

References (54)

1. Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme
2. +-dependent isoform of 11β-hydroxysteroid dehydrogenase. Cloning and characterisation of cDNA from sheep kidney
3. Mineralocorticoid activity of liquorice: 11β-hydroxysteroid dehydrogenase deficiency comes of age
4. Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase
5. Several homozygous mutations in the gene for 11β-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess
6. Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase
7. Mineralocorticoid excess and inhibition of 11β-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome
8. 11β-Hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: Effect of physicochemical and hormonal manipulations
9. Does central obesity reflect 'Cushing's disease of the omentum'?
10. Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
11. 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid inducible responses and resist hyperglycaemia on obesity and stress
12. Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: Possible evidence for a role of hepatic 11β-hydroxysteroid dehydrogenase type 1
13. Cortisol metabolism in human obesity: Impaired cortisone-cortisol conversion in subjects with central adiposity
14. Obesity and gender influence cortisol secretion and metabolism in man
15. Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: Enzymatic modulation of glucocorticoid action
16. Tissue specific effects of thyroid hormone on 11βhydroxysteroid dehydrogenase gene expression
17. Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: The role of growth hormone patterns
18. Tumor necrosis factor α and interleukin 1β enhance the cortisone/cortisol shuttle
19. Renal 11β-hydroxysteroid dehydrogenase activity: Effects of age, sex and altered hormonal status
20. Sex- and tissue-specific regulation of 11β-hydroxysteroid dehydrogenase mRNA
21. Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: Further evidence for the existence of a second dehydrogenase in rat kidney
22. Sex differences in the human metabolism of cortisol
23. Sexual dimorphism in 11β hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects
24. Seasonal variation in glucocorticoid activity in healthy men
25. Dexamethasone and 11-dehydrodexamethasone as tools to investigate the isozymes of 11β-hydroxysteroid dehydrogenase in vitro and in vivo
26. Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11β-hydroxysteroid dehydrogenase in vivo
27. Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man
28. Cortisol and hypertension: What was not so apparent about 'apparent mineralocorticoid excess'
29. Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess
30. Steroid profile for urine: Reference values
31. Urinary adrenal steroid metabolites in tuberculosis-a new clue to pathogenesis?
32. Mineralocorticoid activity of carbenoxolone: Contrasting effects of carbenoxolone and liquorice on 11β-hydroxysteroid dehydrogenase activity in man
33. Licorice-induced hypertension and syndromes of apparent mineralocorticoid excess
34. Cloning and expression of cDNA of human Δ4-3-oxosteroid 5β-reductase and substrate specificity of the expressed enzyme
35. Genetic and pharmacological evidence for more than one human steroid 5α-reductase
36. Identification of cortisone 5β-reductase as Δ4-3-ketosteroid 5β-reductase
37. Purification and characterisation of Δ4-3-ketosteroid 5β-reductase
38. Human hepatic cortisol reductase activities: Enzymatic properties and substrate specificities of cytosolic cortisol Δ4-5β-reductase and dihydrocortisol-3α-oxidoreductase
39. The sexually differentiated Δ4-3-ketosteroid 5β-reductase of rat liver. Purification, characterization, and quantitation
40. Hormonal regulation of activities of 4-ene-5β and 5α-reductases and 17β-ol-dehydrogenase in immature golden hamster ovary
41. Influence of adipose tissue distribution on the biological activity of androgens
42. The 5α-reductase in the central nervous system: Expression and modes of control
43. Expression and regulation of steroid 5α-reductase in the urogenital tract of the fetal rat
44. Steroid 5α-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats
45. Distribution of rat hepatic steroid 5α-reductase 1 as shown by immunohistochemistry
46. 5α-Reductase activity in rat adipose tissue
47. Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5α-reductase
48. Rat adrenal 5α-reductase mRNA content and enzyme activity are sex hormone dependent
49. C19 and C21 5β/5α metabolite ratios in subjects treated with the 5α-reductase inhibitor finasteride: Comparison of male pseudohermaphrodites with inherited 5α-reductase deficiency
50. 5α-Reductase activity in polycystic ovarian syndrome
51. Hyperandrogenism in polycystic ovary syndrome: Evidence of dysregulation of 11β-hydroxysteroid dehydrogenase
52. Issues concerning androgen replacement therapy in postmenopausal women
53. Evidence of coexisting changes in 11β-hydroxysteroid dehydrogenase and 5β-reductase activity in patients with untreated essential hypertension
54. Deficient inactivation of cortisol by 11β-hydroxysteroid dehydrogenase in essential hypertension