Delayed hypersensitivity reactions - Which tests exist? What is the sensitivity and specificity of these tests

Allergy and Clinical Immunology International

Volumn 14, Issue 5, 2002, Pages 194-198

  Merk, Hans F ^a   Dorfmüller, Andreas ^a   Sachs, Bernhard ^a   Baron, Jens M ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; BETA LACTAM ANTIBIOTIC; DIPYRONE; DRUG METABOLIZING ENZYME; LIDOCAINE; PENICILLIN G; SULFONAMIDE; THYMIDINE DERIVATIVE;

ALLERGY TEST; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; DIAGNOSTIC PROCEDURE; DNA DETERMINATION; DNA SYNTHESIS; DRUG METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; KERATINOCYTE; LYMPHOCYTE TRANSFORMATION TEST; MEASUREMENT; PATCH TEST; PATHOPHYSIOLOGY; PENICILLIN ALLERGY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; T LYMPHOCYTE SUBPOPULATION;

EID: 0036709476     PISSN: 08381925     EISSN: None     Source Type: Journal    
DOI: 10.1027/0838-1925.14.5.194     Document Type: Article

References (30)

1. Barbaud A, Reichert-Penetrat S, Trechot P, Jacquin-Petit M-A, Ehlinger A, Noirez V, Faure GC, Schmutz, J-L, Bene MC. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol 1998; 139:49-58
2. Baron JM, Zwadlo-Klarwasser G, Jugert F, Hamann W, Rübben A, Mukhtar H, Merk HF. Cytochrome P450 lBl: A major P450 enzyme in human blood monocytes and macrophage subsets. Biochem Pharmacol 1998; 56:1105-1110
3. Brugnolo F, Annunziato F, Sampognaro S, Campi P, Manfredi M, Matucci A, Blanca M, Romangnani S, Maggi E, Parronchi R Highly Th2-skewed cytokine profile of β-lactam specific T cells from nonatopic subjects with adverse drug reactions. J Immunol 1999; 163:1053-1059
4. Gaspard I, Guinnepain MT, Laurent J, Bachot N, Kerdine S, Bertoglio J, Pallardy M, Lebrec H. IL-4 and IFN-γ mRNA induction in human peripheral lymphocytes specific for β-lactam antibiotics in immediate and delayed hypersensitivity reactions. J Clin Immunol 2000; 20:107-116
5. Griem P, Wulferink M, Sachs B, Gonzales JB, Gleichmann E. Allergic and autoimmune reactions to xenobiotics: How do they start? Immunol Today 1998; 19:133-141
6. Gruchalla R. Understanding drug allergies. J Allergy Clin Immunol 2000; 105:637-644
7. Gruchella R. Clinical assessment of drug-induced disease. Lancet 2000; 356:1505-1511
8. Kohler Ch, Kolopp-Sarda MN, March-Kennel A, Barbaud A, Béné MC, Faure GC. Sequential assessment of cell cycle S phase in flow cytometry: a non-isotopic method to measure lymphocyte activation in vitro. Analyt Cell Pathol 1997; 14:51-59
9. Knowles SR, Uetrecht J, Shear NH. Idiosyncratic drug reactions: The reactive metabolite syndromes. Lancet 2000; 356:1587-1591
10. + T lymphocytes in bullous cutaneous reactions caused by β-lactam antibiotics. J Invest Dermatol 1993; 101:794-799
11. Hertl M, Merk HF. Lymphocyte activation in cutaneous drug reactions. J Invest Dermatol 1995; 105:95S-98S
12. LeCleach L, DeLaire S, Boumsell L, Bagot M, Bourgault-Villada I, Bensussan A, Roujeau JC. Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors. Clin Exp Immunol 2000; 119:225-230
13. Leyva L, Torres MJ, Posadas S, Blanca M, Besso G, O'Valle F, del Moral RG, Santamaria LF, Juarez C. Anticonvulsant-induced toxic epidermal necrolysis: Monitoring the immunologic response. J Allergy Clin Immunol 2000; 105:157-165
14. Merk HF, Schneider R, Scholl P. Lymphocyte stimulation by drug-modified microsomes. In RW Estabrook, E Lindenlaub, F Oesch, & AL de Weck (Eds.) Toxicological and immunological aspects of drug metabolism and environmental chemicals. Stuttgart: Schattauer Verlag, 1987, pp. 211-219
15. Meyer UA. Pharmacogenetics and adverse drug reactions. Lancet 2000; 356:1667-1671
16. Nyfeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy 1997; 27:175-181
17. Padovan E, von Greyerz S, Pichler WJ, Weltzien HU. Antigen-dependent and -independent IFN-γ modulation by penicillins. J Immunol 1999; 162:1171-1177
18. Park BK, Kitteringham NR, Powell H, Pirmohamed M. Advances in molecular toxicology - Towards understanding idiosyncratic drug toxicity. Toxicology 2000; 153:39-60
19. Pichler WJ, Zanni M, von Greyerz S, Schnyder B, Mauri-Hellweg D, Wendland T. High IL-5 production by human drug-specific T-cell clones. Int Arch Allergy Immunol 1997; 113:177-180
20. Reilly TP, Lawrence HL, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol 2000; 114:1164-1173
21. Romano A, Torres MJ, Quarationo D, di Fonso M, Perrone MR, Viola M, Venuti A, Blanca M. Diagnostic evaluation of delayed hypersensitivity to systemically administered drugs. Allergy 1999; 54:S23-27
22. Sachs B, Erdmann S, Borchardt I, Drüke P, Borchardt I, Merk HF. Drug-induced allergic cytopenia: In-vitro confirmation by the Lymphocyte Transformation Test. Arch Intern Med (letter) 2000; 160:2218-2219
23. Sachs B, Erdmann S, al Masaoudi T, Merk HF. Improved sensitivity of in vitro drug-allergy detection by employing a drug-metabolizing system and determination of interleukin-5 in chlorazepate-induced skin rash. Br J Dermatol 2001; 144:316-320
24. Sachs B, Erdmann S, al Masaoudi T, Merk HF. Drug-specific proliferation of peripheral blood mononuclear cells from patients with delayed type immune reactions in the lymphocyte transformation test is consistently associated with interleukin 5 secretion. Immunobiology 2000; 203:279-280 (abstract)
25. Sachs B, Merk H. Demonstration and characterisation of drug-specific lymphocyte reactivity in drug allergies. ACI Intern 2001; 13:91-98
26. + T cells in primary cultures: Relationship to expression of allergic disease. J Allergy Clin Immunol 1997; 99:563-569
27. Uetrecht JP. The role of leukocyte generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metabol Rev 1992; 24:299-366
28. Wolkenstein P, Tan C, Lecoeur S, Wechsler J, Garcia-Martin N, Charue D, Bagot M, Beaune P. Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin. Chem Biol Interact 1998; 113:39-50
29. De Week AL. Penicillins and cephalosporins. In AL de Week, H Bundgaard (Eds.), Handbook of experimental pharmacology. Berlin: Springer Verlag, 1983, vol. 63, pp. 423-482
30. Luque I, Levya L, JoséTorres M, Rosal M, Mayorga C, Segura JM, Blanca M, Juarez C. In vitro T-cell responses to β-lactam drugs in immediate and nonimmediate allergic reactions. Allergy 2001; 56:611-618