Sequestration of aggregated LDL by macrophages studied with freeze-etch electron microscopy

Journal of Lipid Research

Volumn 42, Issue 4, 2001, Pages 605-619

  Haberland, M E ^a   Mottino, G ^a   Le, M ^a   Frank, J S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Atherosclerosis; CURL; LDL gold; Surface tubules for entry into macrophages; Surface connected compartments

Indexed keywords

LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; FOAM CELL; FREEZE FRACTURE; HUMAN; HUMAN CELL; LIPOLYSIS; LYSOSOME; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RABBIT;

ANIMALS; CELLS, CULTURED; CYTOSKELETON; FOAM CELLS; FREEZE ETCHING; GOLD COMPOUNDS; HEART VALVES; HUMANS; LIPOPROTEINS, LDL; LYSOSOMES; MACROPHAGES; MICROSCOPY, ELECTRON; PHOSPHOLIPASE C; RABBITS; TRANSPORT VESICLES;

EID: 0035059735     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The role of monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions
2. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation
3. Fatty streak initiation in Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits
4. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
5. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
6. Modified low-density lipoproteins: Diversity, and biological relevance in atherogenesis
7. Enhanced macrophage uptake of low density lipoprotein after self-aggregation
8. Phagocytosis of aggregated lipoprotein by macrophages: Low density, lipoprotein-dependent foam cell formation
9. Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions
10. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching
11. The response-to-retention hypothesis of early atherogenesis
12. Sequestration of acetylated LDL and cholesterol crystals by human monocyte-macrophages
13. Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages
14. Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation
15. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
16. Protein measurement with the Folin phenol reagent
17. An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit
18. Colloidal gold-low density lipoprotein conjugates as membrane receptor probes
19. Modification of the Recalde method for the isolation of human monocytes
20. Lipid accumulation in rabbit aortic intima 2 h after bolus infusion of low density lipoprotein, A deep-etch and immunolocalization study of ultrarapidly frozen tissue
21. Cellular events in the development of valvular atherosclerotic lesions induced by experimental hyperchoiesterolemia
22. An ultrastructure study of β-very low density lipoprotein uptake and transport by valvular endothelium of hyperlipidemic valves
23. Aggregation and fusion of modified low density lipoprotein
24. Altered ultrastructural morphology of self-aggregated low density, lipoproteins: Coalescence of lipid domains forming droplets and vesicles
25. Uptake and digestion of horseradish peroxidase in rabbit alveolar macrophages. Formation of a pathway connecting lysosomes to the cell surface
26. Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis
27. Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages
28. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system
29. Topographical distribution of coated pits
30. Localization of the binding sites of native and acetylated low density lipoprotein (LDL) in human monocyte-derived macrophages
31. Macrophage uptake of low-density lipoprotein modified by 4-hydroxynonenal. An ultrastructural study
32. Modified LDLs are internalized by macrophages in part by macropinocytosis
33. β-Very-low-density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages
34. Aggregated low density lipoprotein induces and enters surface-connected compartments of human monocyte-macrophages
35. Characterization of patocytosis: Endocytosis into macrophage surface-connected compartments
36. Co-localization of an endocytic marker and acid phosphatase in a tubular/reticular compartment in macrophages
37. Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules
38. Tubular lysosomes accompany stimulated pinocytosis in macrophages
39. A method for co-localization of tubular lysosomes and microtubules in macrophages: Fluorescence microscopy of individual cells
40. Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits