SCOPUS 정보 검색 플랫폼

Volumn 45, Issue 16, 2002, Pages 3524-3530

Discovery of an opioid κ receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphans

(14) Thomas, James B a Atkinson, Robert N a Namdev, Nivedita a Rothman, Richard B b Gigstad, Kenneth M a Fix, Scott E a Mascarella, S Wayne a Burgess, Jason P a Vinson, N Ariane a Xu, Heng b Dersch, Christina M b Cantrell, Buddy E c Zimmerman, Dennis M c Carroll, F Ivy a

a RTI INTERNATIONAL (United States)

b NIDA Addiction Research Center (United States)

c ELI LILLY AND COMPANY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' GUANIDINO NALTRINDOLE; DELTA OPIATE RECEPTOR; ENKEPHALIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N 5 (3 HYDROXY)PHENYL 1,4 METHYL 2 (3 PHENYLPROPYL) 2 AZABICYCLO[3.3.1]NON 7 Y] 3 (1 PIPERIDINYL)PROPANAMIDE; N 5 (3 HYDROXY)PHENYL 4 METHYL 2 (3 PHENYLPROPYL) 2 AZABICYCLO[3.3.1]NON 7 YL 3 (1 PIPERIDINYL)PROPANAMIDE; N 5 (3 HYDROXY)PHENYL 4 METHYL 2 (3 PHENYLPROPYL) 2 AZABICYCLO[3.3.1]NON 7 YL 3 GUANIDINOPROPANAMIDE; N 5 (3 HYDROXY)PHENYL 4 METHYL 2 (3 PHENYLPROPYL) 2 AZABICYCLO[3.3.1]NON 7 YL 4 (N,N DIMETHYLAMINO)BUTANAMIDE; N 5 (3 HYDROXY)PHENYL 4 METHYL 2 (3 PHENYLPROPYL) 2 AZABICYCLO[3.3.1]NON 7 YL 4 GUANIDINOBUTANAMIDE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALTREXONE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE ANTAGONIST; PROPIONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHO CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; LIGAND BINDING; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CHO CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; GUINEA PIGS; HUMANS; LIGANDS; MORPHINANS; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, KAPPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036682415 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm020084h Document Type: Article

Times cited : (24)

References (20)

1
- 0025232625
- Selective opioid receptor agonists and antagonists: Research tools and potential therapeutic agents
- (1990) J. Med. Chem. , vol.33 , pp. 895-902
- Zimmerman, D.M.¹ Leander, J.D.²

2
- 0000092188
- Analgesics
- Wolff, M. E., Ed.; John Wiley & Sons: New York
- (1996) Burger's Medicinal Chemistry and Drug Discovery , vol.3
- Aldrich, J.V.¹

3
- 0016271788
- Improved synthesis and additional pharmacology of the potent analgetic (-)-5-m-hydroxyphenyl-2-methylmorphan
- (1974) J. Med. Chem. , vol.17 , pp. 1328-1330
- Rogers, M.E.¹ May, E.L.²

4
- 0021270879
- Racemic and optically active 2,9-dimethyl-5-(m-hydroxyphenyl)morphans and pharmacological comparison with the 9-demethyl homologues
- (1984) J. Med. Chem. , vol.27 , pp. 536-539
- Awaya, H.¹ May, E.L.² Aceto, M.D.³ Merz, H.⁴ Rogers, M.E.⁵ Harris, L.S.⁶

5
- 15644364959
- N-Substituted 9β-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists
- (1998) J. Med. Chem. , vol.41 , pp. 4143-4149
- Thomas, J.B.¹ Zheng, X.² Mascarella, S.W.³ Rothman, R.B.⁴ Dersch, C.M.⁵ Partilla, J.S.⁶ Flippen-Anderson, J.L.⁷ George, C.F.⁸ Cantrell, B.E.⁹ Zimmerman, D.M.¹⁰ Carroll, F.I.¹¹

6
- 0032542315
- Identification of an opioid K receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine
- (1998) J. Med. Chem. , vol.41 , pp. 5188-5197
- Thomas, J.B.¹ Fall, M.J.² Cooper, J.B.³ Rothman, R.B.⁴ Mascarella, S.W.⁵ Xu, H.⁶ Partilla, J.S.⁷ Dersch, C.M.⁸ McCullough, K.B.⁹ Cantrell, B.E.¹⁰ Zimmerman, D.M.¹¹ Carroll, F.I.¹²

7
- 0035899186
- Identification of the first trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid K receptor antagonist activity
- (2001) J. Med. Chem. , vol.44 , pp. 2687-2690
- Thomas, J.B.¹ Atkinson, R.N.² Rothman, R.B.³ Fix, S.E.⁴ Mascarella, S.W.⁵ Vinson, N.A.⁶ Xu, H.⁷ Dersch, C.M.⁸ Lu, Y.⁹ Cantrell, B.E.¹⁰ Zimmerman, D.M.¹¹ Carroll, F.I.¹²

8
- 0033555221
- A stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans
- (1999) Tetrahedron Lett. , vol.40 , pp. 403-406
- Thomas, J.B.¹ Gigstad, K.M.² Fix, S.E.³ Burgess, J.P.⁴ Cooper, J.B.⁵ Mascarella, S.W.⁶ Cantrell, B.E.⁷ Zimmerman, D.M.⁸ Carroll, F.I.⁹

9
- 0030023640
- Synthesis of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists: Application of the cis-thermal elimination of carbonates to alkaloid synthesis
- (1996) J. Org. Chem. , vol.61 , pp. 587-597
- Werner, J.A.¹ Cerbone, L.R.² Frank, S.A.³ Ward, J.A.⁴ Labib, P.⁵ Tharp-Taylor, R.W.⁶ Ryan, C.W.⁷

10
- 0028940359
- Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)-morphans by application of the message-address concept: Preparation of δ-opioid receptor ligands
- (1995) J. Med. Chem. , vol.38 , pp. 1523-1537
- Bertha, C.M.¹ Flippen-Anderson, J.L.² Rothman, R.B.³ Porreca, F.⁴ Davis, P.⁵ Xu, H.⁶ Becketts, K.⁷ Cha, X.-Y.⁸ Rice, K.C.⁹

11
- 0009835029
- note

12
- 15444345625
- Investigation of the N-substituent conformation governing potency and μ receptor subtype-selectivity in (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)-piperidine opioid antagonists
- (1998) J. Med. Chem. , vol.41 , pp. 1980-1990
- Thomas, J.B.¹ Mascarella, S.W.² Rothman, R.B.³ Partilla, J.S.⁴ Xu, H.⁵ McCullough, K.B.⁶ Dersch, C.M.⁷ Cantrell, B.E.⁸ Zimmerman, D.M.⁹ Carroll, F.I.¹⁰

13
- 0032012257
- Standard binding and functional assays related to (NIDA) Medications Development Division testing for potential cocaine and narcotic treatment programs
- (1998) NIDA Res. Monogr. Ser. , vol.178 , pp. 440-466
- Toll, L.¹ Berzetei-Gurske, I.P.² Polgar, W.E.³ Brandt, S.R.⁴ Adapa, I.D.⁵ Rodriguez, L.⁶ White, A.⁷ Kennedy, J.M.⁸ Craymer, K.⁹ Farrington, L.¹⁰ Auh, J.S.¹¹

14
- 0028986870
- Modulation by μ-opioid agonists of guanosine-5′-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells
- (1995) Mol. Pharmacol. , vol.47 , pp. 848-854
- Traynor, J.R.¹ Nahorski, S.R.²

15
- 0023139286
- Binaltorphimine and nor-binaltorphimine, potent and selective κ-opioid receptor antagonists
- (1987) Life Sci. , vol.40 , pp. 1287-1292
- Portoghese, P.S.¹ Lipkowski, A.W.² Takemori, A.E.³

16
- 0023765567
- Only one pharmacophore is required for the κ opioid antagonist selectivity of norbinaltorphimine
- (1988) J. Med. Chem. , vol.31 , pp. 1344-1347
- Portoghese, P.S.¹ Nagase, H.² Takemori, A.E.³

17
- 0027402575
- 2-alkylamidino)methyl]naltrindole derivatives as a novel class of κ opioid receptor antagonists
- (1993) J. Med. Chem. , vol.36 , pp. 179-180
- Olmsted, S.L.¹ Takemori, A.E.² Portoghese, P.S.³

18
- 0032481059
- Mutational evidence for a common κ antagonist binding pocket in the wild-type κ and mutant μ[K303E] opioid receptors
- (1998) J. Med. Chem. , vol.41 , pp. 4911-4914
- Jones, R.M.¹ Hjorth, S.A.² Schwartz, T.W.³ Portoghese, P.S.⁴

19
- 0017620408
- Schwyzer A short introductory review
- (1977) Ann. N. Y. Acad. Sci. , vol.247 , pp. 3-26
- Schwyzer, R.¹

20
- 0025733775
- An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: δ opioid antagonists
- (1991) J. Med. Chem. , vol.34 , pp. 1757-1762
- Portoghese, P.S.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.