N-substituted 9β-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 4143-4149

  Thomas, James B ^a   Zheng, Xiaoling ^a   Wayne Mascarella, S ^a   Rothman, Richard B ^b   Dersch, Christina M ^b   Partilla, John S ^b   Flippen Anderson, Judith L ^c   George, Clifford F ^c   Cantrell, Buddy E ^d   Zimmerman, Dennis M ^d   Ivy Carroll, F ^a  

^a RTI INTERNATIONAL   (United States)

^b NIDA Addiction Research Center   (United States)

^c NAVAL RESEARCH LABORATORY   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE DERIVATIVE; 4 (3 HYDROXYPHENYL)PIPERIDINE DERIVATIVE; 4 [(4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; 5 (3 HYDROXYPHENYL)MORPHAN DERIVATIVE; DELTA OPIATE RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ETHYLKETAZOCINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR ANTAGONIST; N METHYL 9BETA METHYL 5 (3 HYDROXYPHENYL)MORPHAN DERIVATIVE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; N PHENETHYL 9BETA METHYL 5 (3 HYDROXYPHENYL)MORPHAN DERIVATIVE; NALOXONE; NALTREXONE; OPIATE ANTAGONIST; SULFUR 35; TRITIUM; UNCLASSIFIED DRUG; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; N METHYL 9 METHYL 5 (3 HYDROXYPHENYL)MORPHAN; N PHENETHYL 9 METHYL 5 (3 HYDROXYPHENYL)MORPHAN; N-METHYL-9-METHYL-5-(3-HYDROXYPHENYL)MORPHAN; N-PHENETHYL-9-METHYL-5-(3-HYDROXYPHENYL)MORPHAN; OPIATE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; PUTAMEN; ANIMAL; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; MOLECULAR CONFORMATION; MORPHINANS; PUTAMEN; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15644364959     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980290i     Document Type: Article

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