Priming biologically active antibody responses against an isolated, conformational viral epitope by DNA vaccination

Journal of Immunology

Volumn 169, Issue 3, 2002, Pages 1251-1260

  Riedl, Petra ^a   El Kholy, Shereen ^a   Reimann, Jörg ^a   Schirmbeck, Reinhold ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HEAT SHOCK PROTEIN 73; HEPATITIS B SURFACE ANTIGEN; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS ANTIGEN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG SCREENING; FEMALE; IMMUNOGENICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIMIAN VIRUS 40; TRANSGENIC MOUSE; VACCINATION;

EID: 0036681810     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.3.1251     Document Type: Article

References (51)

1. Recombinant hepatitis B vaccines
2. Surface proteins of hepatitis B virus
3. Formation of intracellular particles by hepatitis B virus large surface protein
4. Properties of modified hepatitis B virus surface antigen particles carrying preS epitopes
5. Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines
6. Role of the pre-S2 domain of the large envelope protein in hepatitis B virus assembly and infectivity
7. Truncated or chimeric endogenous protein antigens gain immunogenicity for B cells by stress protein-facilitated expression
8. The Hsp70 and Hsp60 chaperone machines
9. Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones
10. DNA vector constructs that prime hepatitis B surface antigen-specific cylotoxic T lymphocyte and antibody responses in mice after intramuscular injection
11. d mice that reject syngeneic tumors
12. b-restricted peptide presentation
13. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 and 5, using modified cDNA expression vectors
14. Immunization of mice with the N-terminal (I-272) fragment of simian virus 40 large T-antigen (without adjuvants) specifically primes cytotoxic T lymphocytes
15. Antigenic binding site of monoclonal antibodies specific for simian virus 40 large T antigen
16. + cytotoxic T lymphocytes in mice
17. Deletions in the hepatitis B virus small envelope protein: Effect on assembly and secretion of surface antigen particles
18. Novel transmembrane topology of the hepatitis B virus envelope proteins
19. Polyclonality and multispecificiy of the CTL response to a single viral epitope
20. Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class 1 presentation
21. Polyomavirus T antigens: Molecular chaperones for multiprotein complexes
22. The virus-chaperone connection
23. Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice
24. Ongoing murine T1 or T2 immune responses to the hepatitis B surface antigen are excluded from the liver that expresses transgene-encoded hepatitis B surface antigen
25. Targeting murine immune responses to selected T cell- or antibody- defined determinants of the hepatitis B surface antigen by plasmid DNA vaccines encoding chimeric antigen
26. Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA
27. In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies
28. Novel vaccine approaches
29. DNA vaccines: Immunology, application and optimization
30. Revealing the potential of DNA-based vaccination: Lessons learned from the hepatitis B virus surface antigen
31. DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans
32. DNA-mediated immunization to hepatitis B surface antigen: Longevity of primary response and effect of boost
33. Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen
34. DNA-based immunization against the envelope proteins of the hepatitis B virus
35. Plasmid DNA expressing a secreted or a nonsecreted form of hepatitis C virus nucleocapsid: Comparative studies of antibody and T-helper responses following genetic immunization
36. Comparative study of DNA-based immunization vectors: Effect of secretion signals on the antibody responses in mice
37. Cytokine and hepatitis B virus DNA co-immunizations enhance cellular and humoral immune responses to the middle but not to the large hepatitis B virus surface antigen in mice
38. Hepatitis B surface antigen: An unusual secreted protein initially synthesized as a transmembrane polypeptide
39. Mutational analysis of HBsAg assembly
40. Secretion and antigenicity hepatitis B virus small envelope proteins lacking cysteines in the major antigenic region
41. + T cells to tumor cell antigens by dendritic cells
42. Human class 1 supertypes and CTL repertoires extend to chimpanzees
43. Selective killing of hepatitis B envelope antigen-specific B cells by class 1-restricted, exogenous antigen-specific T lymphocytes
44. Specific cytotoxic T cells eliminate cells producing neutralizing antibodies
45. + T cells
46. Induction of anergy in CD8 T cells by B cell presentation of antigen
47. B cells inhibit induction of T cell-dependent tumor immunity
48. T cell priming in vivo: A major role for B cells in presenting antigen to T cells in lymph modes
49. Murine HIV-I p24 specific T lymphocyte activation by different antigen presenting cells: B lymphocytes from immunized mice present core protein to T cells
50. Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptormediated uptake
51. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes