Induction of xenograft accommodation by modulation of elicited antibody responses

Transplantation

Volumn 74, Issue 3, 2002, Pages 334-345

  Wang, Ning ^a   Lee, Jang Ming ^a   Tobiasch, Edda ^a   Csizmadia, Eva ^a   Smith, Neal R ^a   Gollackes, Bend ^a   Robson, Simon C ^a   Bach, Fritz H ^a   Lin, Yuan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; IMMUNOGLOBULIN M;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BABOON; CONTROLLED STUDY; ENDOTHELIUM; GENE TRANSFER; GRAFT SURVIVAL; HEART TRANSPLANTATION; NONHUMAN; POSTOPERATIVE CARE; PREOPERATIVE CARE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLENECTOMY; SURVIVAL; SYRIAN HAMSTER;

EID: 0036678189     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200208150-00008     Document Type: Article

References (63)

1. Delayed xenograft rejection
2. The immunological barriers to xenotransplantation
3. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants
4. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection
5. The role of natural antibodies in the activation of xenogenic endothelial cells
6. Role of endothelial cells in transplantation
7. Acute humoral xenograft rejection: Destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts
8. Endothelial cell activation and thromboregulation during xenograft rejection
9. Delayed xenograft rejection in the concordant hamster heart into Lewis rat model
10. Long-term survival of hamster hearts in presensitized rats
11. Suppression of delayed xenograft rejection by specific depletion of elicited antibodies of the IgM isotype
12. Induction of long-term survival of hamster heart xenografts in rats
13. Accommodation of vascularized xenografts: Expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment
14. Protective genes expressed in endothelial cells: A regulatory response to injury
15. A perspective on xenograft rejection and accommodation
16. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB
17. A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis
18. Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury
19. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
20. Expression of heme oxygenase-1 can determine cardiac xenograft survival
21. Graft adaptation in hamster-to-rat cardiac xenografts
22. Accommodated xenografts survive in the presence of anti-donor antibodies and complement that precipitate rejection of naive xenografts
23. Human IgM xenoreactive natural antibodies can induce resistance of porcine endothelial cells to complement-mediated injury
24. In vitro accommodation of immortalized porcine endothelial cells: Resistance to complement mediated lysis and down-regulation of VCAM expression induced by low concentrations of polyclonal human IgG anti-pig antibodies
25. Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a Gal alpha(1-3)Gal binding lectin: Up-regulation of CD59 expression
26. Splenectomy is a potent immunosuppressive modality for cardiac xenografting
27. +dull splenic B cells
28. Quantitation of the changes in splenic architecture during the rejection of cardiac allografts or xenografts
29. Suppression of T-independent IgM xeno-antibody formation by leflunomide during xenografting of hamster hearts in rats
30. Expression of human thrombomodulin cofactor activity in porcine endothelial cells
31. Induction of mixed hematopoietic chimerism in the pig-to-baboon model
32. Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction
33. Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis
34. Camouflaging endothelial cells: Dose it prolong graft survival?
35. Flow cytometry evaluation of cell-mediated cytotoxicity
36. Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts
37. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection
38. The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light-microscopic immunocytochemical studies of mouse spleen, lymph node, and Peyer's patch
39. Development and maturation of secondary lymphoid tissues
40. IgMhighCD21 high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
41. The origin of marginal-zone cells
42. Effect of splenectomy in combination with FK 506 and 15-deoxyspergualin on cardiac xenograft survival
43. Synergistic effect of anti-T cell receptor monoclonal antibody and 15-deoxyspergualin on cardiac xenograft survival in a mouse-to-rat model
44. Paradoxical effects of xenografting in the nude rat: Effect of splenectomy on aberrant graft rejection
45. Timing of splenectomy is critical in prolongation of cardiac xenografts
46. Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model
47. Xenograft adaptation is dependent on the presence of antispecies antibody, not prolonged residence in the recipient
48. Lack of accommodation after long-term survival of hamster xenografts in rats
49. The heme oxygenase system: A regulator of second messenger gases
50. Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury
51. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: Protective effect against heme and hemoglobin toxicity
52. Reduced stress defense in heme oxygenase 1-deficient cells
53. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury
54. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury
55. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
56. Renal allograft rejection: Expression and function of VCAM-1 on tubular epithelial cells
57. In vitro accommodation of porcine endothelial cells by low dose human anti-pig antibody: Reduced binding of human lymphocytes by accommodated cells associated with increased nitric oxide production
58. Nitric oxide: Physiology, pathophysiology, and pharmacology
59. Modulation of platelet aggregation by an L-arginine-nitric oxide pathway
60. Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit
61. Human complement regulatory proteins in transgenic animals regulate complement activation in xenoperfused organs
62. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
63. Modulation of nucleotide triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection