In vitro accommodation of immortalized porcine endothelial cells: Resistance to complement mediated lysis and down-regulation of VCAM expression induced by low concentrations of polyclonal human IgG antipig antibodies

Transplantation

Volumn 62, Issue 8, 1996, Pages 1127-1136

  Dorling, Anthony ^a   Stocker, Claire ^a   Tsao, Twee ^a   Haskard, Dorian O ^a   Lechler, Robert I ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYCLONAL ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL IMMORTALIZATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENDOTHELIUM CELL; FIBROBLAST CULTURE; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE ACTIVATION; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; AORTA; CELL LINE; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; HUMANS; RECEPTORS, FIBRONECTIN; SWINE; TRANSPLANTATION, HETEROLOGOUS; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0029908712     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199610270-00018     Document Type: Article

References (65)

1. Dorling A, Lechler RI. Prospects for xenografting. Curr Opin Immunol 1994; 6: 765.
2. Ye Y, Niekrasz M, Kosanke S, et al. The pig as a potential organ donor for man. Transplantation 1994; 57: 694.
3. Magee JC, Platt JL. Xenograft rejection molecular mechanisms and therapeutic implications. Therapeutic Immunology 1994; 1: 45.
4. Bach FH, Blakely ML, Van der Werf M, et al. Discordant xenografting: a working model of problems and issues. Xenotransplantation 1993; 1: 8.
5. Platt JL, Bach FH. The barrier to xenotransplantation. Transplantation 1991; 52: 937.
6. Sandrin MS, Vaughan HA, Dabkowski PL, McKenzie IFC. Antipig IgM antibodies in human serum react predominantly with gal(α1 3)gal epitopes. Proc Natl Acad Sci USA 1993; 90: 11391.
7. Leventhal JR, Dalmasso AP, Cranwell JW, et al. Prolongation of cardiac xenograft survival by depletion of complement. Transplantation 1993; 55: 857.
8. Leventhal JR, Matas AJ, Sun LH, et al. The immunopathology of cardiac xenograft rejection in the guinea pig to rat model. Transplantation 1993; 56: 1.
9. Pruitt SK, Kirk AD, Bollinger RR, et al. The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. Transplantation 1994; 57: 363.
10. Figueroa J, Fuad SA, Kmjummen BD, Platt JL, Bach FH. Suppression of synthesis of natural antibodies by mycophenolate mofetil (RS 61443). Transplantation 1993; 55: 1371.
11. Good AH, Cooper DKC, Malcolm AJ, et al. Identification of carbohydrate structures that bind human anti porcine antibodies: implications for discordant xenografting in humans. Transplant Proc 1992; 24: 559.
12. Rydberg L, Hallberg E, Björck S, et al. Studies on the removal of antipig xenoantibodies in the human by plasmapheresis/immunoadsorption. Xenotransplantation 1995; 2: 253.
13. Tuso PJ, Cramer DV, Yasunaga C, Cosenza LA, Wu GD, Makowka L. Removal of natural human xenoantibodies to PI vascular endothelium by perfusion of blood through pig kidneys and livers. Transplantation 1993; 55: 1375.
14. Leventhal JR, Sakiyalak P, Witson J, et al. The synergistic effect of combined antibody and complement depletion on discordant cardiac xenograft survival in nonhuman primates. Transplantation 1994; 57: 974.
15. Platt JL, Fischel RJ, Matas AJ, Reif SA, Bolman RM, Bach FH. Immunopathology of hyperacute xenograft rejection in a s wine to primate model. Transplantation 1991; 52: 214.
16. Fischel RJ, Bolman RM, Platt JL, Najarian JS, Bach FH, Matas AJ. Removal of IgM anti endothelial antibodies results in prolonged cardiac xenograft survival. Transplant Proc 1990; 22: 1077.
17. Alexandre G, Gianello P, Latinne D, et al. Plasmapheresis and splenectomy in experimental renal transplantation. In: Hardy MA, ed. Xenograft 25. New York: Elsevier, 1989: 259.
18. Fischel RJ, Platt JL, Matas AJ, et al. Prolonged survival of a discordant cardiac xenograft in a rhesus monkey. Translant Proc 1991; 23: 589.
19. Winkler H, Ferran C, Bach FH. Accommodation of xenografts: a concept revisited. Xenotransplantation 1995; 2: 53.
20. Platt JL, Vercellotti GM, Dalmasso AP, et al. Transplantation of discordant xenografts: a review of progress. Immunol Today 1990; 11: 450.
21. Alexandre GPJ, Latinne D, Gianello P, Squifflet JP. Pre-formed cytotoxic antibodies and ABO incompatible grafts. Clin Transplant 1991; 5: 583.
22. Ross CN, Gaskin G, Gregor Macgregor S, et al. Renal transplantation following immunoadsorption in highly sensitized recipients. Transplantation 1993; 55: 785.
23. Balla G, Jacob HS, Balla J, et al. Ferritin: a cytoprotective antioxidant stratagem of endothelium. J Biol Chem 1992; 267: 18148.
24. Hasan R, Van den Bogaerde J, Forty J, Wright L, Wallwork J, White DJG. Xenograft adaptation is dependent on the presence of antispecies antibody, not prolonged residence in the recipient. Transplant Proc 1992; 24: 531.
25. Gilbert MA, Chareau B, Vicart P, Paulin D, Nandi PK. Mechanism of entry of a xenotropic MMuLV derived recombinant retrovirus into porcine cells using the expression of the reporter nlslacZ genes. Arch Virol 1992; 124: 57.
26. Dodi AI, Brett S, Nordeng T, et al. The invariant chain inhibits presentation of endogenous antigens by a human fibroblast cell line. Eur J Immunol 1994; 24: 1632.
27. Jat PS, Sharp PA. Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts. J Virol 1986; 59: 746.
28. Larsky LA. Selectins: interpreters of cell specific carbohydrate information during inflammation. Science 1992; 258: 964.
29. Springer TA. Adhesion receptors of the immune system. Nature 1990; 346: 425.
30. Voyta JC, Via DP, Butterfield CE, Zetter Br Identification and isolation of endothelial cells based on their increased uptake of acetylated low density lipoprotein. J Cell Biol 1984; 99: 2034.
31. Wellicome SM, Thornhill MH, Thomas DS, Pitzalis C, Lanchbury JSS, Haskard DO. A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumour necrosis factor. IL 1 or lipopolysaccharide. J Immunol 1990; 144: 2558.
32. Tsang YTM, Haskard DO, Robinson MK. Cloning and expression kinetics of porcine vascular cell adhesion molecule. Biochem Biophys Res Comm 1991; 201: 805.
33. Gunning P, Leavitt J, Muscat G, Ng SY, Kedes L. A human β actin expression vector system directs high level accumulation of anti sense transcripts. Proc Natl Acad Sci USA 1987; 84: 4831.
34. Miller J, Germain RN. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. J Exp Med 1986; 164; 1478.
35. Graham FC, Van Der Eb VJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973; 52: 456.
36. Mulligan RC, Berg P. Selection for animal cells that express the Escherichia coli gene coding for xanthine guanine phosphoribosyltransferase. Proc Natl Acad Sci USA 1981; 78: 2072.
37. Scott PAE, Bicknell R. The isolation and culture of microvascular endothelium. J Cell Sci 1993; 105: 269.
38. Collins BH, Parker W, Platt JL. Characterisation of porcine endothelial cell determinants recognised by human natural antibodies. Xenotransplantation 1994; 1: 36.
39. Dalmasso AP, Vercellotti GM, Platt JL, Bach FH. Inhibition of complement mediated endothelial cell cytotoxicity by decay accelerating factor. Transplantation 1991; 52: 530.
40. Vaughan HA, Loveland BE, Sandrin MS. Galα(1-3)gal is the major xenoepitope expressed on pig endothelial cells recognised by naturally occurring cytotoxic human antibodies. Transplantation 1994; 58: 879.
41. Borche L, Thibaudeau K, Navenot JM, Blanchard D. Cytolytic effect of human anti-Gal IgM and complement on porcine endothelial cells: a kinetic analysis. Xenotransplantation 1994; 1: 125.
42. van Kooyk Y, van de Wiel van Kemande E, Weder P, Huijbens RJF, Figdor CG. Lymphocyte function associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium. J Exp Med 1993; 177: 185.
43. Gautreau C, Kojima T, Woimant G, Cardoso J, Devillier P, Houssin D. Use of intravenous immunoglobulin to delay xenogeneic hyperacute rejection. Transplantation 1995; 60: 903.
44. Khodadoust MK, Candal FJ, Maher SE, et al. PEC A: an immortalized porcine aortic endothelial cell. Xenotransplantation 1995; 2: 79.
45. Vicart P, Testut P, Schwartz B, Llorens Cortes C, Perdomo JJ, Paulin D. Cell adhesion markers are expressed by a stable human endothelial cell line transformed by the SV40 large T antigen under vimentin promoter control. J Cell Physiol 1993; 157: 41.
46. Rollins SA, Matis LA, Springhorn JP, Setter E, Wolff DW. Monoclonal antibodies directed against human C5 and C8 block complement mediated damage of xenogeneic cells and organs. Transplantation 1995; 60: 1284.
47. Platt JL, Dalmasso AP, Lindman BJ, Ihrcke NS, Bach FH. The role of C5a and antibody in the release of heparan sulfate from endothelial cells. Eur J Immunol 1991; 21: 2887.
48. Platt JL, Vercellotti GM, Lindman BJ, Oegema TR, Bach FH, Dalmasso AP. Release of heparan sulfate from endothelial cells. J Exp Med 1990; 171: 1363.
49. Clements JM, Newham P, Shepherd M, et al. Identification of a key integrin binding sequence in VCAM 1 homologous to the LDV active site in fibronectin. J Cell Science 1994; 107: 2127.
50. Mueller JP, Evans MJ, Cofiell R, Rother RP, Matis LA, Elliot EA. Porcine vascular cell adhesion molecule (VCAM) mediates endothelial cell adhesion to human T cells. Development of blocking antibodies specific for porcine VCAM. Transplantation 1995; 60: 1299.
51. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301.
52. Damle NK, Klussman K, Linsley PS, Aruffo A. Differential co stimulatory effects of adhesion molecules B7. ICAm 1. LFA 3 and VCAM 1 on resting and antigen primed CD4+ T lymphocytes. J Immunol 1992; 148: 1985
53. van Seventer GA, Newman W, Shimizu Y, et al. Analysis of T cell stimulation by superantigen plus MHC class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM 1. ICAM 1 but not ELAM 1. J Exp Med 1991; 174: 901.
54. Pinola M, Saksela E, Tiisala S, Renkonen R. Human NK cells expressing α4β1/β7 adhere to VCAM 1 without pre activation. Scand J Immunol 1994; 39: 131.
55. Takahashi M, Ikeda U, Masuyama JI, et al. Involvement of adhesion molecules in human monocyte adhesion to and transmigration through endothelial cells in vitro. Atherosclerosis 1994; 108: 73.
56. Pascual M, French LE. Complement in human diseases: looking towards the 21st century. Immunol Today 1995; 16: 58.
57. Glotz D, Genevaz D, Latremouille C, Kaveri S. Intravenous polyclonal immunoglobulins in autoimmunity and transplantation. Xeno 1995; 3: 30.
58. Vanhove B, de Martin R, Lipp J, Bach FH. Human xenoreactive natural antibodies of the IgM isotype activate pig endothelial cells. Xenotransplantation 1994; 1: 17.
59. Cooke SP, Hederer RA, Pearson JD, Savage COS. Characterisation of human IgG binding xenoantigens expressed by porcine aortic endothelial cells. Transplantation 1995; 60: 1274.
60. Platt JL, Lindman BJ, Chen H, Spitalnik SL, Bach FH. Endothelial cell antigens recognised by xenoreactive human natural antibodies. Transplantation 1990; 50: 817.
61. Platt JL, Holzknecht ZE. Poreine platelet antigens recognized by human xenoreactive natural antibodies. Transplantation 1994; 57: 327.
62. De Caterina R, Cybulsky MI, Clinton SK, Gimbrone MA, Libby P. The omega 3 fatty acid docosahexaenoate reduces cytokine induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb 1994; 14: 1829.
63. Weber C, Erl W, Pietsch A, Danesch U, Weber PC. Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule 1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor α. Arterioscler Thromb Vasc Biol 1995; 15: 622.
64. Weber C, Erl W, Pietsch A, Ströbel M, Ziegler Heitbrock HWL, Weber PC. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor κB mobilization and induction of vascular cell adhesion molecule 1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb 1994; 14: 1665.
65. de Martin R, Vanhove B, Cheng Q, et al. Cytokine inducible expression in endothelial cells of an IκBα like gene is regulated by NFκB. EMBO J 1993; 12: 2773.