Stable expression of antisense hTR inhibits in vitro pancreatic cancer cell growth

Chinese Medical Journal

Volumn 115, Issue 8, 2002, Pages 1196-1200

  Teng, Lisong ^a,b   Chen, Shimei ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Antisense; hTR; Pancreatic carcinoma cell line; Telomerase

Indexed keywords

COMPLEMENTARY DNA; LIPOFECTIN; PLASMID DNA; PRIMER DNA; RNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE; COMPLEMENTARY RNA; DNA BINDING PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA VECTOR; DOWN REGULATION; ENZYME ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GROWTH RATE; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL; MOLECULAR CLONING; PANCREAS CANCER; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SCREENING; SENESCENCE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; CELL CULTURE; DRUG ANTAGONISM; GENETICS; PANCREAS TUMOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

HUMAN; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, ANTISENSE; TELOMERASE; TUMOR CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS;

EID: 0036674729     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
2. Specific association of human telomerase activity with immortal cells and cancer
3. Telomeres, telomerase, and immortality
4. A survey of telomerase activity in human cancer
5. Telomerase activity, cell proliferation, and cancer
6. Clinical implications of telomerase in cancer
7. The RNA component of human telomerase
8. hEst2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
9. Inhibition of human telomerase activity by peptide nucleic acids
10. The implications of telomerase biochemistry for human disease
11. Telomerase in cancer: Diagnostic, prognostic, and therapeutic implications
12. Telomerase in the early detection of cancer
13. High telomerase activity in primary lung cancers: Association with increased cell proliferation rates and advanced pathologic stage
14. A mammalian telomerase-associated protein
15. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
16. Telomerase catalytic subunit homologs from fission yeast and human
17. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
18. Mutational analysis of the Tetrahymena telomerase RNA: Identification of residues affecting telomerase activity in vitro
19. Functional reconstitution of wild-type and mutant Tetrahymena telomerase
20. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
21. Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability
22. Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA
23. Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides