De novo chemical ligand design

Drug Discovery Today

Volumn 7, Issue 15, 2002, Pages 802-803

  Chan, Ting Fung ^a   Steven Zheng, X F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD; LIGAND;

ALGORITHM; CHEMICAL GENETICS; COMBINATORIAL CHEMISTRY; COMPUTER; DATA BASE; ENERGY TRANSFER; HYDROGEN BOND; LIGAND BINDING; MOLECULAR BIOLOGY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SHORT SURVEY; SYNTHESIS; DRUG DESIGN; HUMAN; METHODOLOGY; NOTE; RESEARCH;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HUMAN; LIGANDS; RESEARCH; HUMANS;

EID: 0036668395     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02363-2     Document Type: Short Survey

References (7)

1. Chemical genomics: A systematic approach in biological research and drug discovery
2. Computational approaches to structure-based ligand design
3. Probes for chemical genomics by design
4. A computational procedure for determining energetically favorable binding sites on biologically important macromolecules
5. Functionality maps of binding sites: A multiple copy simultaneous search method
6. Synergy between combinatorial chemistry and de novo design
7. Combinatorial informatics in the post-genomic era