The Otx family

Current Opinion in Genetics and Development

Volumn 12, Issue 4, 2002, Pages 409-415

  Simeone, Antonio ^a   Puelles, Eduardo ^b   Acampora, Dario ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHORDIN; LIM PROTEIN; MESSENGER RNA; NOGGIN; PROTEIN; PROTEIN OTX1; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; OTX1 PROTEIN, MOUSE; OTX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR OTX;

BRAIN REGION; DROSOPHILA; EMBRYO DEVELOPMENT; GASTRULATION; MORPHOGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; ANIMAL; BRAIN; EVOLUTION; GENETICS; MOUSE; MULTIGENE FAMILY; PHYSIOLOGY; PRENATAL DEVELOPMENT;

DROSOPHILA; MURINAE; VERTEBRATA;

ANIMALS; BRAIN; EVOLUTION; HOMEODOMAIN PROTEINS; MICE; MULTIGENE FAMILY; OTX TRANSCRIPTION FACTORS;

EID: 0036668279     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00318-0     Document Type: Review

References (46)

1. Axis development and early asymmetry in mammals
2. Initial patterning of the central nervous system: How many organizers?
3. Regionalization of the prosencephalic neural plate
4. Mouse gastrulation: The formation of a mammalian body plan
5. Nested expression domains of four homeobox genes in developing rostral brain
6. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
7. Understanding the roles of Otx1 and Otx2 in controlling brain morphogenesis
8. Epilepsy and brain abnormalities in mice lacking Otx1 gene
9. Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets
10. Otx1 and Otx2 activities are required for the normal development of the mouse iner ear
11. Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
12. Mouse Otx2 functions in the formation and patterning of rostral head
13. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
14. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
15. Visceral endoderm-restricted translation of Otx1 mediates recovering of Otx2 requirements for specification of anterior neural plate and proper gastrulation
16. The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
17. The organizer factors Chordin and Noggin are required for mouse forebrain development
18. Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
19. Morphogens, compartments, and pattern: Lessons from Drosophila?
20. Induction of a mesencephalic phenotype in the 2 day-old chick prosencephalon is preceded by the early expression of the homeobox gene en
21. Midbrain development induced by FGF8 in the chick embryo
22. Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
23. The midbrain-hindbrain boundary organizer
24. Neural plate patterning: Upstream and downstream of the isthmic organizer
25. Positioning the isthmic organizer where Otx2 and Gbx2 meet
26. Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8
27. Genetic control of brain morphogenesis through Otx gene dosage requirement
28. Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain
29. The caudal limit of Otx2 expression positions the isthmic organizer
30. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer dependent on Gbx2 gene function
31. A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
32. Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
33. Regionalization of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2
34. Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3′ UTR
35. Emx2 directs the development of diencephalon in cooperation with Otx2
36. Pax6 defines the di mesencephalic boundary by repressing En1 and Pax2
37. Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
38. Functional equivalency between Otx2 and Otx1 in development of the rostral head
39. Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development
40. OTD/OTX2 functional equivalence depends on 5′ and 3′ UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast- restricted translation
41. Drosophila engrailed can substitute for mouse Engrailed 1 function in mid-hindbrain, but not limb development
42. Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development
43. Evolution and homology of the nervous system: Cross-phylum rescues of Otd/Otx genes
44. Conserved usage of gap and homeotic genes in patterning the CNS
45. Otx genes in brain morphogenesis
46. The future of evolutionary developmental biology