Psychological effects of a drug that facilitates brain AMPA receptors

International Clinical Psychopharmacology

Volumn 11, Issue 1, 1996, Pages 13-19

  Lynch, G ^a   Kessler, M ^a   Rogers, G ^b   Ambros Ingerson, J ^a   Granger, R ^a   Schehr, R S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cortex Pharmaceuticals Inc ^*  (United States)

Author keywords

AMPA receptor modulator; BDP 12; blood pressure; CX516; EWL test; heart rate; human subjects; pharmacokinetics; triplet memory recall test

Indexed keywords

6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; AMPA RECEPTOR; PIPERIDINE DERIVATIVE; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; MOOD; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOLOGIC TEST;

EID: 0029991210     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004850-199603000-00002     Document Type: Article

References (10)

1. Arai A, Kessler M, Xiao P, Ambros-Ingerson J, Rogers G and Lynch G (1994) A centrally active drug that modulates AMPA receptor gated currents. Brain Research, 638, 343-346.
2. Granger R, Staubli U, Davis M, Perez Y, Nilsson L, Rogers GA and Lynch G (1996) A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning dependent task. Synapse, 15, 326-329.
3. Granger R, Deadwyler S, Davis M, Moskovitz B, Rogers G and Lynch G (1995) Facilitation of glutamate receptors reverses an age-associated memory impairment in rats. Synapse, in press.
4. Janke W and Debus G (1978) Die Eigenschaftswörterliste. Hogrefe, Göttingen.
5. Larson J, Lieu T, Petchpradub V, LeDuc B, Ngo H, Rogers GA and Lynch G (1996) Facilitation of olfactory learning by a modulator of AMPA receptors. Journal of Neuroscience, 15, 8023-8030.
6. Masliah E, Mallory M, Hansen L, DeTeresa R and Terry RD (1993) Quantitative synaptic alterations in the human neocortex during normal aging. Neurology, 43, 192-197.
7. Rogan M, Staubli U and LeDoux JE (1994) Facilitation of AMPA receptors accelerates classical fear conditioning in rats. Society of Neuroscience Abstracts, 20, 1007.
8. Shors TJ, Servatius RJ, Thompson RF, Rogers G and Lynch G (1995) Enhanced glutamatergic neurotransmission facilitates classical conditioning in the freely-moving rat. Neuroscience Letters, 186, 153-156.
9. Staubli U, Rogers G and Lynch G (1994a) Facilitation of glutamate receptors enhances memory. Proceedings of the National Academy of Sciences of the USA, 91, 777-781.
10. Staubli U, Perez Y, Xu F, Rogers G, Ingvar M, Stone-Elander S and Lynch G (1994b) Centrally active modulators of glutamate (AMPA) receptors facilitate the induction of LTP in vivo. Proceedings of the National Academy of Sciences of the USA, 91, 11158-11162.