메뉴 건너뛰기




Volumn 56, Issue 3, 2002, Pages 335-346

Preclinical experiments on cognition enhancement in Alzheimer's disease: Drugs affecting nicotinic acetylcholine receptors

Author keywords

Acetylcholine; Acetylcholinesterase inhibition; Allosteric modulation; Dementia; Eyeblink classical conditioning; Learning; Memory; Nicotinic acetylcholine receptors (nAChRs), 7 nAChR agonism or antagonism, normal aging

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLINESTERASE INHIBITOR; GALANTAMINE; NEFIRACETAM; NICOTINIC AGENT; NICOTINIC RECEPTOR; NOOTROPIC AGENT;

EID: 0036659998     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10086     Document Type: Review
Times cited : (7)

References (98)
  • 1
    • 0002503154 scopus 로고    scopus 로고
    • Beta-amyloid peptides as direct cholinergic neuromodulators. A missing link?
    • Auld DS, Kar S, Quirion R. 1998. Beta-amyloid peptides as direct cholinergic neuromodulators. A missing link? TINS 21:43-49.
    • (1998) TINS , vol.21 , pp. 43-49
    • Auld, D.S.1    Kar, S.2    Quirion, R.3
  • 3
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten following the cholinergic hypothesis
    • Bartus RT. 2000. On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten following the cholinergic hypothesis. Exp Neurol 163:495-529.
    • (2000) Exp Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 4
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RL, Beer B. Lippa AS 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 6
    • 0017133142 scopus 로고
    • Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies
    • Bowen DM, Smith CB, White P, Davison AN. 1976. Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99:459-496.
    • (1976) Brain , vol.99 , pp. 459-496
    • Bowen, D.M.1    Smith, C.B.2    White, P.3    Davison, A.N.4
  • 7
    • 0026754804 scopus 로고
    • The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain
    • Conroy WG, Vernallis AB, Berg DK. 1992. The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain. Neuron 9:679-691.
    • (1992) Neuron , vol.9 , pp. 679-691
    • Conroy, W.G.1    Vernallis, A.B.2    Berg, D.K.3
  • 8
    • 0025828670 scopus 로고
    • Pentameric structure and subunit stoichiometry of a neuronal acetylcholine receptor
    • Cooper E, Couturier S, Ballivet M. 1991. Pentameric structure and subunit stoichiometry of a neuronal acetylcholine receptor. Nature 350:235-238.
    • (1991) Nature , vol.350 , pp. 235-238
    • Cooper, E.1    Couturier, S.2    Ballivet, M.3
  • 9
    • 0001833216 scopus 로고
    • Distribution of nicotinic receptors in the CNS
    • Stone TW, editor. London: CRC Press
    • Court JA, Perry EK. 1995. Distribution of nicotinic receptors in the CNS. In: Stone TW, editor. CNS neurotransmitters and neuromodulators. London: CRC Press. p 85-104.
    • (1995) CNS neurotransmitters and neuromodulators , pp. 85-104
    • Court, J.A.1    Perry, E.K.2
  • 10
    • 0025605864 scopus 로고
    • A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX
    • Couturier S, Bertrand D, Matter JM, Hernandez MC, Bertrand S, Millar N, Valera S, Barkas T, Ballivet M. 1990. A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX. Neuron 5:847-856.
    • (1990) Neuron , vol.5 , pp. 847-856
    • Couturier, S.1    Bertrand, D.2    Matter, J.M.3    Hernandez, M.C.4    Bertrand, S.5    Millar, N.6    Valera, S.7    Barkas, T.8    Ballivet, M.9
  • 11
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, DeLong MR. 1983. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 219:1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 13
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P, Maloney AJF. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.F.2
  • 15
    • 0014014090 scopus 로고
    • Anticholinesterase induced amnesia and its temporal aspects
    • Deutsch JA, Hamburg MD, Dahl H. 1966. Anticholinesterase induced amnesia and its temporal aspects. Science 151:221-223.
    • (1966) Science , vol.151 , pp. 221-223
    • Deutsch, J.A.1    Hamburg, M.D.2    Dahl, H.3
  • 16
    • 0035875962 scopus 로고    scopus 로고
    • Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    • Dineley KT, Westerman M, Bui D, Beli K, Ashe KH, Sweatt JD. 2001. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 21:4125-4133.
    • (2001) J Neurosci , vol.21 , pp. 4125-4133
    • Dineley, K.T.1    Westerman, M.2    Bui, D.3    Beli, K.4    Ashe, K.H.5    Sweatt, J.D.6
  • 17
    • 0032531893 scopus 로고    scopus 로고
    • Synaptic potentials mediated via α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons
    • Frazier CJ, Buhler AV, Weiner JL, Dunwiddie TV 1998. Synaptic potentials mediated via α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons. J Neurosci 18:8228-8235.
    • (1998) J Neurosci , vol.18 , pp. 8228-8235
    • Frazier, C.J.1    Buhler, A.V.2    Weiner, J.L.3    Dunwiddie, T.V.4
  • 18
    • 0021672436 scopus 로고
    • Changes of dopamine metabolism by hypoxia effect of nootropic drugs
    • Funk KF, Schmidt J. Changes of dopamine metabolism by hypoxia and effect of nootropic drugs. Biomed Biochem Acta 1984;11:1301-1304.
    • (1984) Biomed Biochem Acta , vol.11 , pp. 1301-1304
    • Funk, K.F.1    Schmidt, J.2
  • 19
    • 0032973078 scopus 로고    scopus 로고
    • Nicotine enhancement of contextual fear conditioning is specific for the contextual association but not the CS-US association
    • Gould TJ, Wehner JW. 1999. Nicotine enhancement of contextual fear conditioning is specific for the contextual association but not the CS-US association. Behav Brain Res 102:31-39.
    • (1999) Behav Brain Res , vol.102 , pp. 31-39
    • Gould, T.J.1    Wehner, J.W.2
  • 20
    • 0034958525 scopus 로고    scopus 로고
    • Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition
    • Gould TJ,Collins AC, Wehner JW. 2001. Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition. Nicotine Tob Res 1:17-24.
    • (2001) Nicotine Tob Res , vol.1 , pp. 17-24
    • Gould, T.J.1    Collins, A.C.2    Wehner, J.W.3
  • 21
    • 0010796040 scopus 로고    scopus 로고
    • Eyeblink classical conditioning in aging animals
    • Woodruff-Pak DS, Steinmetz JE, editors. Boston: Kluwer
    • Green JT, Woodruff-Pak DS. 2000. Eyeblink classical conditioning in aging animals, In: Woodruff-Pak DS, Steinmetz JE, editors. Eyeblink classical conditioning: Volume II, Animal models. Boston: Kluwer. p 155-178.
    • (2000) Eyeblink classical conditioning: Volume II, Animal models , vol.2 , pp. 155-178
    • Green, J.T.1    Woodruff-Pak, D.S.2
  • 22
    • 0032756213 scopus 로고    scopus 로고
    • Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenillin-1 mutations: Lack of association with amyloid deposits
    • Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. 1999. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenillin-1 mutations: Lack of association with amyloid deposits. Behav Genet 29:177-185.
    • (1999) Behav Genet , vol.29 , pp. 177-185
    • Holcomb, L.A.1    Gordon, M.N.2    Jantzen, P.3    Hsiao, K.4    Duff, K.5    Morgan, D.6
  • 23
    • 0031450275 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors as targets for drug discovery
    • Holliday MW, Dart MJ, Lynch JK. 1997. Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J Med Disc 40:4169-4194.
    • (1997) J Med Disc , vol.40 , pp. 4169-4194
    • Holliday, M.W.1    Dart, M.J.2    Lynch, J.K.3
  • 24
    • 0014984163 scopus 로고
    • Isolation and structure of a hoplonemertine toxin
    • Kem WR, Abbott BC, Coates RM. 1971. Isolation and structure of a hoplonemertine toxin. Toxicol 9:15-22.
    • (1971) Toxicol , vol.9 , pp. 15-22
    • Kem, W.R.1    Abbott, B.C.2    Coates, R.M.3
  • 25
    • 0031459933 scopus 로고    scopus 로고
    • Anabaseine is a potent agonist on muscle and neuronal αbungarotoxin-sensitive nicotinic receptors
    • Kem WR, Mahnir VM, Papke RL, Lingle CJ. 1997. Anabaseine is a potent agonist on muscle and neuronal αbungarotoxin-sensitive nicotinic receptors. J Pharmacol Exp Ther 283:979-992.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 979-992
    • Kem, W.R.1    Mahnir, V.M.2    Papke, R.L.3    Lingle, C.J.4
  • 28
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee VM.-Y, Balin BJ, Otvos L Jr, Trojanowsld JQ 1991. A68: A major subunit of paired helical filaments and derivatized forms of normal tau. Science 251:675-678.
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos L., Jr.3    Trojanowsld, J.Q.4
  • 29
    • 0002770011 scopus 로고    scopus 로고
    • Functional MRI studies of eyeblink classical conditioning
    • 1000. Woodruff-Pak DS and Steinmetz JE, editors. Boston:Kluwer Academic Publishers
    • Lemieux SK, Woodruff-Pak DS, 1000. Functional MRI studies of eyeblink classical conditioning. In: Woodruff-Pak DS and Steinmetz JE, editors. Eyeblink classical conditioning Volume I: Applications in humans, Boston:Kluwer Academic Publishers. p 71-93.
    • Eyeblink classical conditioning Volume I: Applications in humans , vol.1 , pp. 71-93
    • Lemieux, S.K.1    Woodruff-Pak, D.S.2
  • 30
    • 0026649175 scopus 로고
    • Nicotinic systems and cognitive function
    • Levin ED. 1992. Nicotinic systems and cognitive function. Psychopharmacol 108:417-431.
    • (1992) Psychopharmacol , vol.108 , pp. 417-431
    • Levin, E.D.1
  • 31
    • 0029690580 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors
    • Lindstrom J. 1996. Neuronal nicotinic acetylcholine receptors. Ion Chan 4:377-450.
    • (1996) Ion Chan , vol.4 , pp. 377-450
    • Lindstrom, J.1
  • 32
    • 0025781805 scopus 로고
    • The nicotinic acetylcholine receptor gene family: Structure of nicotinic receptors from muscle and neurons and neuronal α-bungarotoxin-binding proteins
    • Lindstrom J, Schoepfer R, Conroy W, Whiting P, Das M, Saedi M, Anand R. 1991. The nicotinic acetylcholine receptor gene family: Structure of nicotinic receptors from muscle and neurons and neuronal α-bungarotoxin-binding proteins. Adv Exp Med Biol 287:255-278.
    • (1991) Adv Exp Med Biol , vol.287 , pp. 255-278
    • Lindstrom, J.1    Schoepfer, R.2    Conroy, W.3    Whiting, P.4    Das, M.5    Saedi, M.6    Anand, R.7
  • 34
    • 0035836747 scopus 로고    scopus 로고
    • β-amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons
    • Liu Q.-S, Kawai H, Berg DK, 2001. β-amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons, Proc Nat Acad Sci USA 98:4734-4739.
    • (2001) Proc Nat Acad Sci USA , vol.98 , pp. 4734-4739
    • Liu, Q.-S.1    Kawai, H.2    Berg, D.K.3
  • 35
    • 0029081596 scopus 로고
    • Functional anatomy of human eyeblink classical conditioning determined with regional cerebral glucose metabolism and positron-emission topography
    • Logan CG, Grafton ST, 1995. Functional anatomy of human eyeblink classical conditioning determined with regional cerebral glucose metabolism and positron-emission topography. Proc Nat Acad Sci USA 92:7500-7504.
    • (1995) Proc Nat Acad Sci USA , vol.92 , pp. 7500-7504
    • Logan, C.G.1    Grafton, S.T.2
  • 36
    • 0024342046 scopus 로고
    • Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia
    • London ED, Ball MJ Waller SB. 1989. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia. Neurochem Res 14:745-750.
    • (1989) Neurochem Res , vol.14 , pp. 745-750
    • London, E.D.1    Ball, M.J.2    Waller, S.B.3
  • 38
    • 0033845742 scopus 로고    scopus 로고
    • Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease
    • Maelicke A, Schrattenholz A, Samochocki M, Radina M, Albuquerque EX. 2000. Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease. Behav Brain Res 113:199-206.
    • (2000) Behav Brain Res , vol.113 , pp. 199-206
    • Maelicke, A.1    Schrattenholz, A.2    Samochocki, M.3    Radina, M.4    Albuquerque, E.X.5
  • 39
    • 0025039780 scopus 로고
    • Oxiracetam increases the release of endogenous glutamate from depolarized rat hippocampal slices
    • Marchi M, Besana E, Raiteri M. 1990. Oxiracetam increases the release of endogenous glutamate from depolarized rat hippocampal slices. Eur J Pharmacol 185:247-249.
    • (1990) Eur J Pharmacol , vol.185 , pp. 247-249
    • Marchi, M.1    Besana, E.2    Raiteri, M.3
  • 41
    • 0032974888 scopus 로고    scopus 로고
    • Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor 670/671 mutation
    • Marutle A, Warpman U, Bognanovic N, Lannfelt L, Nordberg A. 1999. Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor 670/671 mutation. J Neurochem 72:1161-1169.
    • (1999) J Neurochem , vol.72 , pp. 1161-1169
    • Marutle, A.1    Warpman, U.2    Bognanovic, N.3    Lannfelt, L.4    Nordberg, A.5
  • 42
    • 0028965629 scopus 로고
    • Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons
    • McGehee DS, Role LW. 1995. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Ann Rev Physiol 57:521-546.
    • (1995) Ann Rev Physiol , vol.57 , pp. 521-546
    • McGehee, D.S.1    Role, L.W.2
  • 43
    • 0029096914 scopus 로고
    • Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
    • McGehee DS, Heath MJ, Gelber S, Devay P, Role LW. 1995. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269:1692-1696.
    • (1995) Science , vol.269 , pp. 1692-1696
    • McGehee, D.S.1    Heath, M.J.2    Gelber, S.3    Devay, P.4    Role, L.W.5
  • 46
    • 0017145950 scopus 로고
    • Central cholinergic blockade by scopolamine and habituation, classical conditioning, and latent inhibition of the rabbit's nictitating membrane response
    • Moore JW, Goodell NA, Solomon PR. 1976.Central cholinergic blockade by scopolamine and habituation, classical conditioning, and latent inhibition of the rabbit's nictitating membrane response. Physiol Psychol 4:395-399.
    • (1976) Physiol Psychol , vol.4 , pp. 395-399
    • Moore, J.W.1    Goodell, N.A.2    Solomon, P.R.3
  • 47
    • 0026907151 scopus 로고
    • A pathogenic mutation for probably Alzheimer's disease in the APP gene at the N-terminus of β-amyloid
    • Mullan J, Crawford F, Axelman K, Houlden H, Lillius L, Winblad B. 1992. A pathogenic mutation for probably Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nat Genet 1:345-347.
    • (1992) Nat Genet , vol.1 , pp. 345-347
    • Mullan, J.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lillius, L.5    Winblad, B.6
  • 48
    • 0025309740 scopus 로고
    • Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions
    • Nabeshima T, Noda Y, Tohyama K, Itoh J, Kameyama T. 1990. Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions. Eur J Pharmacol 178:143-149.
    • (1990) Eur J Pharmacol , vol.178 , pp. 143-149
    • Nabeshima, T.1    Noda, Y.2    Tohyama, K.3    Itoh, J.4    Kameyama, T.5
  • 49
    • 0000270075 scopus 로고    scopus 로고
    • Clinical aspects of nicotinic agents: Therapeutic application in central nervous system disorders
    • Clementi F, Fornasari D, Gotti C, editors. Berlin: Springer
    • Newhouse PA, Kelton M. 2000. Clinical aspects of nicotinic agents: Therapeutic application in central nervous system disorders. In: Clementi F, Fornasari D, Gotti C, editors. Neuronal nicotinic receptors: experimental pharmacology, Vol. 14. Berlin: Springer. p 779-812.
    • (2000) Neuronal nicotinic receptors: experimental pharmacology , vol.14 , pp. 779-812
    • Newhouse, P.A.1    Kelton, M.2
  • 50
    • 0034233626 scopus 로고    scopus 로고
    • The antidementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors
    • Nishizaki T, Nomura T, Matuoka T, Kondoh T, Enikolopo G, Sumikawa K, Watabe S, Shiotani T, Yoshii M. 2000. The antidementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors, Mol Brain Res 80:53-62.
    • (2000) Mol Brain Res , vol.80 , pp. 53-62
    • Nishizaki, T.1    Nomura, T.2    Matuoka, T.3    Kondoh, T.4    Enikolopo, G.5    Sumikawa, K.6    Watabe, S.7    Shiotani, T.8    Yoshii, M.9
  • 51
    • 0035251677 scopus 로고    scopus 로고
    • Nicotinic receptor abnormalities of Alzheimer's disease: Therapeutic implications
    • Nordberg A. 2001. Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications. Biol Psych 49:200-210.
    • (2001) Biol Psych , vol.49 , pp. 200-210
    • Nordberg, A.1
  • 52
    • 0022930972 scopus 로고
    • Reduced number of 3H-nicotine and 3H-acetylcholine binding sites in the frontal cortex of Alzheimer's brains
    • Nordberg A, Winblad B. 1986. Reduced number of 3H-nicotine and 3H-acetylcholine binding sites in the frontal cortex of Alzheimer's brains. Neurosci Lett 12:115-119.
    • (1986) Neurosci Lett , vol.12 , pp. 115-119
    • Nordberg, A.1    Winblad, B.2
  • 54
    • 0019989399 scopus 로고
    • The action of piracetam on the electrical activity of the hippocampal slice preparation: A field potential analysis
    • Olpe H-R, Lynch GS. 1982. The action of piracetam on the electrical activity of the hippocampal slice preparation: a field potential analysis. Eur J Pharmacol 80:415-419.
    • (1982) Eur J Pharmacol , vol.80 , pp. 415-419
    • Olpe, H.-R.1    Lynch, G.S.2
  • 55
    • 0036239156 scopus 로고    scopus 로고
    • Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit
    • Pak JT, Green JT, Heifetz B, Pak MH, Woodruff-Pak DS. 2002. Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit. Med Sci Monitor 8:105-112.
    • (2002) Med Sci Monitor , vol.8 , pp. 105-112
    • Pak, J.T.1    Green, J.T.2    Heifetz, B.3    Pak, M.H.4    Woodruff-Pak, D.S.5
  • 56
    • 0002052128 scopus 로고
    • A one-year longitudinal investigation of eyeblink classical conditioning and cognitive and behavioral tests in adults with Down's syndrome
    • Papka M, Simon EW, Woodruff-Pak DS. 1994. A one-year longitudinal investigation of eyeblink classical conditioning and cognitive and behavioral tests in adults with Down's syndrome. Aging Cognition 1:89-104.
    • (1994) Aging Cognition , vol.1 , pp. 89-104
    • Papka, M.1    Simon, E.W.2    Woodruff-Pak, D.S.3
  • 57
    • 0035037736 scopus 로고    scopus 로고
    • Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes
    • Papke RL, Sanberg PR, Shytle RD 2001 Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J Pharmacol Exp Ther 297:646-656.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 646-656
    • Papke, R.L.1    Sanberg, P.R.2    Shytle, R.D.3
  • 58
    • 0027964304 scopus 로고
    • Physostigmine and galantamine: Probes for a novel binding site on the α4β2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells
    • Pereira EFR, Alkondon M, Reinhardt S, Maelicke A, Peng X, Lindstrom J, Whiting P, Albuquerque EX. 1994. Physostigmine and galantamine: probes for a novel binding site on the α4β2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells. J Pharmacol Exp Ther 270:768-778.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 768-778
    • Pereira, E.F.R.1    Alkondon, M.2    Reinhardt, S.3    Maelicke, A.4    Peng, X.5    Lindstrom, J.6    Whiting, P.7    Albuquerque, E.X.8
  • 59
    • 0027432528 scopus 로고
    • Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons
    • Pereira EFR, Reinhardt-Maelicke S, Schrattenholz A, Maelicke A, Albuquerque EX. 1993. Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. J PharmacoI Exp Ther 265:1474-1491.
    • (1993) J PharmacoI Exp Ther , vol.265 , pp. 1474-1491
    • Pereira, E.F.R.1    Reinhardt-Maelicke, S.2    Schrattenholz, A.3    Maelicke, A.4    Albuquerque, E.X.5
  • 60
    • 0017360731 scopus 로고
    • Necropsy evidence of central cholinergic deficits in senile dementia
    • Perry EK, Perry RH, Blessed G, Tomlinson BE. 1977. Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1:189.
    • (1977) Lancet , vol.1 , pp. 189
    • Perry, E.K.1    Perry, R.H.2    Blessed, G.3    Tomlinson, B.E.4
  • 62
    • 0035826925 scopus 로고    scopus 로고
    • Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review)
    • Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Commings JL, DeKosky ST. 2001. Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Neurology 56:1133-1142.
    • (2001) Neurology , vol.56 , pp. 1133-1142
    • Petersen, R.C.1    Stevens, J.C.2    Ganguli, M.3    Tangalos, E.G.4    Commings, J.L.5    DeKosky, S.T.6
  • 63
    • 0002006427 scopus 로고    scopus 로고
    • 1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice
    • 1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice. J Neurosci 21:1-5.
    • (2001) J Neurosci , vol.21 , pp. 1-5
    • Pettit, D.L.1    Shao, Z.2    Yakel, J.L.3
  • 64
    • 0033638273 scopus 로고    scopus 로고
    • Learning- and expectation-related changes in the human brain during motor learning
    • Ramnani N, Toni I, Josephs J, Ashburner J, Passingham RE. 2000. Learning- and expectation-related changes in the human brain during motor learning. J Neurophysiol 84:3026-3035.
    • (2000) J Neurophysiol , vol.84 , pp. 3026-3035
    • Ramnani, N.1    Toni, I.2    Josephs, J.3    Ashburner, J.4    Passingham, R.E.5
  • 65
    • 0028211386 scopus 로고
    • Nicotine and tetrahydroaminoacradine: Evidence for improved attention in patients with dementia of the Alzheimer type
    • Sahakian BJ, Coull JT 1994. Nicotine and tetrahydroaminoacradine: evidence for improved attention in patients with dementia of the Alzheimer type. Drug Dev Res 31:80-88.
    • (1994) Drug Dev Res , vol.31 , pp. 80-88
    • Sahakian, B.J.1    Coull, J.T.2
  • 66
    • 0022499441 scopus 로고
    • Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea pig hippocampal slices
    • Satoh M, Ishihara K, Iwama T, Takagi H. 1986. Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea pig hippocampal slices. Neurosci Lett 68:216-220.
    • (1986) Neurosci Lett , vol.68 , pp. 216-220
    • Satoh, M.1    Ishihara, K.2    Iwama, T.3    Takagi, H.4
  • 67
    • 0025308827 scopus 로고
    • Brain α-bungarotoxin-binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily
    • Schoepfer R, Conroy W, Whiting P, Gore M, Lindstrom J. 1990. Brain α-bungarotoxin-binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. Neuron 5:35-48.
    • (1990) Neuron , vol.5 , pp. 35-48
    • Schoepfer, R.1    Conroy, W.2    Whiting, P.3    Gore, M.4    Lindstrom, J.5
  • 68
    • 0025898437 scopus 로고
    • Nicotinic cholinergic receptive neurons of the frontal cortex are reduced in Alzheimer's disease
    • Schroder G, Giacobini E, Struble RG, Zilles K, Maelicke A. 1991. Nicotinic cholinergic receptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol Aging 12:259-262.
    • (1991) Neurobiol Aging , vol.12 , pp. 259-262
    • Schroder, G.1    Giacobini, E.2    Struble, R.G.3    Zilles, K.4    Maelicke, A.5
  • 69
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature, 399:A23-A31.
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 70
    • 0035251752 scopus 로고    scopus 로고
    • Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity
    • Shimohama S. Kihara T 2001. Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity. Biol Psych 49:233-239.
    • (2001) Biol Psych , vol.49 , pp. 233-239
    • Shimohama, S.1    Kihara, T.2
  • 71
    • 0019556817 scopus 로고
    • The septo-hippocampal choliner gic system and classical conditioning of the rabbit's nictitating membrane response
    • Solomon PR, Gottfried KE. 1981. The septo-hippocampal choliner gic system and classical conditioning of the rabbit's nictitating membrane response. J Comp Physiol Psychol 95:322-330.
    • (1981) J Comp Physiol Psychol , vol.95 , pp. 322-330
    • Solomon, P.R.1    Gottfried, K.E.2
  • 72
    • 0020568856 scopus 로고
    • Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure
    • Solomon PR, Solomon SD, Vander Schaaf E, Perry HE. 1983. Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure. Science 220:329-331.
    • (1983) Science , vol.220 , pp. 329-331
    • Solomon, P.R.1    Solomon, S.D.2    Vander Schaaf, E.3    Perry, H.E.4
  • 73
    • 0025770133 scopus 로고
    • Disruption of classical conditioning in patients with Alzheimer's disease
    • Solomon PR, Levine E, Bein T, Pendlebury WW. 1991. Disruption of classical conditioning in patients with Alzheimer's disease. Neurobiol Aging 12:283-287.
    • (1991) Neurobiol Aging , vol.12 , pp. 283-287
    • Solomon, P.R.1    Levine, E.2    Bein, T.3    Pendlebury, W.W.4
  • 75
    • 0023181845 scopus 로고
    • Interactions between oxiracetam, quaniracetam, and scopolamine on behavior and brain acetylcholine
    • Spignoli G, Pepeu G. 1987. Interactions between oxiracetam, quaniracetam, and scopolamine on behavior and brain acetylcholine. Pharmacol Biochem Behav 27:491-495.
    • (1987) Pharmacol Biochem Behav , vol.27 , pp. 491-495
    • Spignoli, G.1    Pepeu, G.2
  • 76
    • 0002518376 scopus 로고    scopus 로고
    • The brain substrates of classical eyeblink conditioning in rabbits
    • Bloedel JR, Ebner TJ, Wise SP, editors. Cambridge, MA: MIT Press
    • Steinmetz JE. 1996. The brain substrates of classical eyeblink conditioning in rabbits. In: Bloedel JR, Ebner TJ, Wise SP, editors. The acquisition of motor behavior in vertebrates. Cambridge, MA: MIT Press. p 89-114,
    • (1996) The acquisition of motor behavior in vertebrates , pp. 89-114
    • Steinmetz, J.E.1
  • 78
    • 0002671545 scopus 로고    scopus 로고
    • Discovering the brain substrates of eyeblink classical conditioning
    • Woodruff-Pak DS, Steinmetz JE, editors. Boston: Kluwer Academic Publishers
    • Thompson RF. 2000. Discovering the brain substrates of eyeblink classical conditioning. In: Woodruff-Pak DS, Steinmetz JE, editors. Eyeblink classical conditioning: Volume II: Animal models. Boston: Kluwer Academic Publishers. p 17-49.
    • (2000) Eyeblink classical conditioning: Volume II: Animal models , vol.2 , pp. 17-49
    • Thompson, R.F.1
  • 79
    • 0028231217 scopus 로고
    • Organization of memory traces in the mammalian brain
    • Thompson RF, Krupa DJ. 1994. Organization of memory traces in the mammalian brain. Ann Rev Neurosci 17:519-549.
    • (1994) Ann Rev Neurosci , vol.17 , pp. 519-549
    • Thompson, R.F.1    Krupa, D.J.2
  • 80
    • 0033624509 scopus 로고    scopus 로고
    • Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors
    • Wang HY, Lee DH, Davis CB, Shank RP. 2000. Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem 75:1155-1161.
    • (2000) J Neurochem , vol.75 , pp. 1155-1161
    • Wang, H.Y.1    Lee, D.H.2    Davis, C.B.3    Shank, R.P.4
  • 82
    • 84989454036 scopus 로고
    • Evaluation of cognition-enhancing drugs: Utility of the model system of eyeblink classical conditioning
    • Woodruff-Pak DS. 1995. Evaluation of cognition-enhancing drugs: Utility of the model system of eyeblink classical conditioning. CNS Drug Rev 1:107-128.
    • (1995) CNS Drug Rev , vol.1 , pp. 107-128
    • Woodruff-Pak, D.S.1
  • 83
    • 0035317868 scopus 로고    scopus 로고
    • Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease
    • Woodruff-Pak DS. 2001. Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease. Integrative Physiol Behav Sci 36:87-108.
    • (2001) Integrative Physiol Behav Sci , vol.36 , pp. 87-108
    • Woodruff-Pak, D.S.1
  • 84
    • 0030989567 scopus 로고    scopus 로고
    • Scopolamine- or mecamylamine-induced learning impairment: Reversed by nefiracetam
    • Woodruff-Pak DS, Hinchliffe RM. 1997. Scopolamine- or mecamylamine-induced learning impairment: reversed by nefiracetam. Psychopharmacology 131:130-139.
    • (1997) Psychopharmacology , vol.131 , pp. 130-139
    • Woodruff-Pak, D.S.1    Hinchliffe, R.M.2
  • 85
    • 0030178576 scopus 로고    scopus 로고
    • Huntington's disease and eyeblink classical conditioning: Normal learning but abnormal timing
    • Woodruff-Pak DS, Papka M. 1996. Huntington's disease and eyeblink classical conditioning: Normal learning but abnormal timing. J Int Neuropsychol Soc 2:323-334.
    • (1996) J Int Neuropsychol Soc , vol.2 , pp. 323-334
    • Woodruff-Pak, D.S.1    Papka, M.2
  • 86
    • 0033845741 scopus 로고    scopus 로고
    • Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease
    • Woodruff-Pak DS, Santos I. 2000. Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease. Behav Brain Res 113:11-19.
    • (2000) Behav Brain Res , vol.113 , pp. 11-19
    • Woodruff-Pak, D.S.1    Santos, I.2
  • 87
    • 0000317805 scopus 로고
    • A model system demonstrating parallels in animal and human aging: Extension to Alzheimer's disease
    • Meyer EM, Simpkins JW, Yamamoto J, editors. New York: Plenum Press
    • Woodruff DS, Finkbiner RG, Katz IR. 1989. A model system demonstrating parallels in animal and human aging: extension to Alzheimer's disease. In: Meyer EM, Simpkins JW, Yamamoto J, editors. Novel approaches to the treatment of Alzheimer's disease. New York: Plenum Press. p. 355-371.
    • (1989) Novel approaches to the treatment of Alzheimer's disease , pp. 355-371
    • Woodruff, D.S.1    Finkbiner, R.G.2    Katz, I.R.3
  • 88
    • 0025615547 scopus 로고
    • Eyeblink conditioning discriminates Alzheimer's patients from non-demented aged
    • Woodruff-Pak DS, Finkbiner RG, Sasse DK, 1990. Eyeblink conditioning discriminates Alzheimer's patients from non-demented aged. NeuroReport 1:45-49.
    • (1990) NeuroReport , vol.1 , pp. 45-49
    • Woodruff-Pak, D.S.1    Finkbiner, R.G.2    Sasse, D.K.3
  • 89
    • 0028352414 scopus 로고
    • Nefiracetam (DM-9384): Effect on classical conditioning in older rabbits
    • Woodruff-Pak DS, Li Y-T. 1994. Nefiracetam (DM-9384): effect on classical conditioning in older rabbits. Psychopharmacology 114:200-208.
    • (1994) Psychopharmacology , vol.114 , pp. 200-208
    • Woodruff-Pak, D.S.1    Li, Y.-T.2
  • 90
    • 0028341821 scopus 로고
    • Nicotinic cholinergic system involvement of eyeblink classical conditioning in rabbits
    • Woodruff-Pak DS, Li Y-T, Kazmi A, Kem WR. 1994a. Nicotinic cholinergic system involvement of eyeblink classical conditioning in rabbits. Behav Neurosci 108:486-493.
    • (1994) Behav Neurosci , vol.108 , pp. 486-493
    • Woodruff-Pak, D.S.1    Li, Y.-T.2    Kazmi, A.3    Kem, W.R.4
  • 91
    • 0028199608 scopus 로고
    • A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain
    • Woodruff-Pak DS, Li Y-T, Kem WR. 1994b. A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain. Brain Res 645:309-317.
    • (1994) Brain Res , vol.645 , pp. 309-317
    • Woodruff-Pak, D.S.1    Li, Y.-T.2    Kem, W.R.3
  • 92
    • 0002002988 scopus 로고
    • Eyeblink classical conditioning in Down's Syndrome, Fragile X Syndrome, and normal adults over and under age 35
    • Woodruff-Pak DS, Papka M, Simon EW. 1994c. Eyeblink classical conditioning in Down's Syndrome, Fragile X Syndrome, and normal adults over and under age 35. Neuropsychol 8:14-24.
    • (1994) Neuropsychol , vol.8 , pp. 14-24
    • Woodruff-Pak, D.S.1    Papka, M.2    Simon, E.W.3
  • 93
    • 0029787674 scopus 로고    scopus 로고
    • Eyeblink classical conditioning in Alzheimer's disease and cerebrovascular dementia
    • Woodruff-Pak DS, Papka M, Romano S, Li Y-T. 1996a. Eyeblink classical conditioning in Alzheimer's disease and cerebrovascular dementia. Neurobiol Aging 17:505-512.
    • (1996) Neurobiol Aging , vol.17 , pp. 505-512
    • Woodruff-Pak, D.S.1    Papka, M.2    Romano, S.3    Li, Y.-T.4
  • 94
    • 0030042148 scopus 로고    scopus 로고
    • Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly
    • Woodruff-Pak DS, Romano S, Papka M. 1996b. Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly. Behav Neurosci 110:22-29.
    • (1996) Behav Neurosci , vol.110 , pp. 22-29
    • Woodruff-Pak, D.S.1    Romano, S.2    Papka, M.3
  • 95
    • 0031039999 scopus 로고    scopus 로고
    • Hippocampus in delay eyeblink classical conditioning: Essential for nefiracetam of learning in older rabbits
    • Woodruff-Pak DS, Li Y-T, Hinchcliffe RM, Port RL. 1997. Hippocampus in delay eyeblink classical conditioning: essential for nefiracetam of learning in older rabbits. Brain Res 747:207-218.
    • (1997) Brain Res , vol.747 , pp. 207-218
    • Woodruff-Pak, D.S.1    Li, Y.-T.2    Hinchcliffe, R.M.3    Port, R.L.4
  • 96
    • 0033736632 scopus 로고    scopus 로고
    • A nicotinic cholinergic drug (GTS-21) and eyeblink classical conditioning: Acquisition, retention, and relearning in older rabbits
    • Woodruff-Pak DS, Green JT, Coleman-Valencia C, Pak JT. 2000. A nicotinic cholinergic drug (GTS-21) and eyeblink classical conditioning: acquisition, retention, and relearning in older rabbits. Exp Aging Res 26;323-336.
    • (2000) Exp Aging Res , vol.26 , pp. 323-336
    • Woodruff-Pak, D.S.1    Green, J.T.2    Coleman-Valencia, C.3    Pak, J.T.4
  • 97
    • 0035852773 scopus 로고    scopus 로고
    • Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
    • Woodruff-Pak DS, Vogel RW III, Wenk GL. 2001. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proc Natl Acad Sci USA 98:2089-2094.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2089-2094
    • Woodruff-Pak, D.S.1    Vogel R.W. III2    Wenk, G.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.