Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly

Behavioral Neuroscience

Volumn 110, Issue 1, 1996, Pages 22-29

  Woodruff Pak, Diana S ^a,b   Romano, Sandra ^b   Papka, Michelle ^a,b,c  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; DOWN SYNDROME; EYELID REFLEX; FEMALE; HUMAN; LEARNING; MALE; RABBIT; TRISOMY 21;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BLINKING; CHOLINERGIC FIBERS; CONDITIONING, CLASSICAL; CONDITIONING, EYELID; DOWN SYNDROME; FEMALE; HUMANS; MALE; MIDDLE AGED; REFERENCE VALUES; RETENTION (PSYCHOLOGY);

EID: 0030042148     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.110.1.22     Document Type: Article

References (38)

1. Berger, T. W., Berry, S. D., & Thompson, R. F. (1986). Role of the hippocampus in classical conditioning of aversive and appetitive behaviors. In R. L. Isaacson & K. H. Pribram (Eds.), The hippocampus (Vol. IV, pp. 203-239). New York: Plenum.
2. Blessed, G., Tomlinson, B. E., & Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral gray matter of elderly subjects. British Journal of Psychiatry, 114, 797-811.
3. Daum, I., Channon, S., & Canavan, A. G. M. (1989). Classical conditioning in patients with severe memory problems. Journal of Neurology, Neurosurgery, and Psychiatry, 52, 47-51.
4. Daum, I., Channon, S., Polkey, C. E., & Gray, J. A. (1991). Classical conditioning after temporal lobe lesions in man: Impairment in conditional discrimination. Behavioral Neuroscience, 105, 396-408.
5. Daum, I., Schugens, M. Ackermann, H , Lutzenberger, W., Dichgans, J., & Birbaumer, N. (1993). Classical conditioning after cerebellar lesions in humans. Behavioral Neuroscience, 107, 748-756.
6. Gormenzano, I. (1966). Classical conditioning. In J. B. Sidowski (Ed.), Experimental methods and instrumentation in psychology (pp. 385-420). New York: McGraw-Hill.
7. Ferrante, L. S., & Woodruff-Pak, D. S. (1995). Longitudinal investigation of eyeblink classical conditioning in the old-old. Journal of Gerontology: Psychological Science, 50, P42-P50.
8. Harvey, J. A., Gormenzano, I., & Cool-Hauser, V. A. (1983). Effects of scopolamine and methylscopolamine on classical conditioning of the rabbit nictitating membrane response. Journal of Pharmacology and Experimental Therapeutics, 225, 42-49.
9. Lavond, D. G., Hembree, T. L., & Thompson, R. F. (1985). Effect of kainic acid lesions of the cerebellar interpositus nucleus on eyelid conditioning in the rabbit. Brain Research, 326, 179-182.
10. Li, Y.-T., Woodruff-Pak, D. S. & Trojanowski, J. Q. (1994). Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites. Neurobiology of Aging, 15, 1-9.
11. McCormick, D. A. & Thompson, R. F. (1984). Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane/eyeblink response. Journal of Neuroscience, 4, 2811-2822.
12. McKahn, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939-944.
13. Moore, J. W., Goodell, N. A., & Solomon, P. R. (1976). Central cholinergic blockage by scopolamine and habituation, classical conditioning, and latent inhibition of the rabbit's nictitating membrane response. Physiological Psychology, 4, 395-399.
14. Papka, M., Ivry, R., & Woodruff-Pak, D. S. (1994). Eyeblink classical conditioning and time production in patients with cerebellar damage. Society for Neuroscience Abstracts, 20, 360.
15. Papka, M., Simon, E. W. & Woodruff-Pak, D. S. (1994). A one-year longitudinal investigation of eyeblink classical conditioning and cognitive and behavioral tests in adults with down's syndrome. Aging and Cognition, 1, 89-104.
16. Schmaltz, L. W., & Theios, J. (1972). Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits (Oryctolagus cuniculus). Journal of Comparative and Physiological Psychology, 79, 328-333.
17. Slosson, R. I. (1985). Slosson Intelligence Test. New York: Slosson Educational Publications.
18. Solomon, P. R., Brett, M., Groccia-Ellison, M., Oyler, C., Tomasi, M., & Pendlebury, W. W. (1995). Classical conditioning in patients with Alzheimer's disease: A multiday study. Psychology and Aging, 10, 248-254.
19. Solomon, P. R., Groccia-Ellison, M., Flynn, D., Mirak, J., Edwards, K. R., Dunehew, A., & Stanton, M. E. (1993). Disruption of human eyeblink conditioning after central cholinergic blockade with scopolamine. Behavioral Neuroscience, 107, 271-279.
20. Solomon, P. R., Levine, E., Bein, T., & Pendlebury, W. W. (1991). Disruption of classical conditioning in patients with Alzheimer's disease. Neurobiology of Aging, 12, 283-287.
21. Solomon, P. R. & Moore, J. W. (1975). Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablations. Journal of Comparative and Physiological Psychology, 89, 1192-1203.
22. Solomon, P. R., Solomon, S. D., Vander Schaaf, E., & Perry, H. E. (1983). Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure. Science, 220, 329-331.
23. Thase, M. E. (1988). The relationship between Down syndrome and Alzheimer's disease. In L. Nadel (Ed.), The psychobiology of Down syndrome (pp. 345-368). Cambridge, MA: MIT Press.
24. Topka, H., Valls-Sole, J., Massaquoi, S. G., & Hallett, M. (1993). Deficit in classical conditioning in patients with cerebellar degeneration. Brain, 116, 961-969.
25. Weiskrantz, L. & Warrington, E. K. (1979). Conditioning in amnesic patients. Neuropsychologica, 17, 187-194.
26. Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985). Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Annals of Neurology, 17, 278-282.
27. Woodruff-Pak, D. S. (1993). Eyeblink classical conditioning in H.M. Delay and trace paradigms. Behavioral Neuroscience, 107, 911-925.
28. Woodruff-Pak, D. S., Cronholm, J. F., & Sheffield, J. B. (1990). Purkinje cell number related to rate of eyeblink classical conditioning. NeuroReport, 1, 165-168.
29. Woodruff-Pak, D. S., & Finkbiner, R. G. (1995). Larger nondeclarative than declarative deficits in learning and memory in human aging. Psychology and Aging, 10, 416-426.
30. Woodruff-Pak, D. S., Finkbiner, R. G., & Katz, I. R. (1989). A model system demonstrating parallels in animal and human aging: Extension to Alzheimer's disease. In E. M. Meyer, J. W. Simpkins, & J. Yamamoto (Eds.), Novel approaches to the treatment of Alzheimer's disease (pp. 357-373). New York: Plenum.
31. Woodruff-Pak, D. S., Finkbiner, R. G., & Sasse, D. K. (1990). Eyeblink classical conditioning discriminates Alzheimer's patients from non-demented aged. NeuroReport, 1, 45-49.
32. Woodruff-Pak, D. S., & Papka, M. (in press). Probable Alzheimer's disease patients are impaired less in the trace than in the delay eyeblink classical conditioning paradigm. Neurobiology of Aging.
33. Woodruff-Pak, D. S., Papka, M., Romano, S., & Li, Y.-T. (in press). Eyeblink classical conditioning in Alzheimer's disease and cerebrovascular dementia. Neurobiology of Aging.
34. Woodruff-Pak, D. S., Papka, M., & Simon, E. W. (1994). Eyeblink classical conditioning in Down's syndrome, fragile X syndrome, and normal adults over and under age 35. Neuropsychology, 8, 14-24.
35. Woodruff-Pak, D. S. & Thompson, R. F. (1988). Classical conditioning of the eyeblink response in the delay paradigm in adults aged 18-83 years. Psychology and Aging, 3, 219-229.
36. Yates, C. M., Ritchie, I. M., Simpson, J., Maloney, A. F. J., & Gordon, A. (1981). Noradrenaline in Alzheimer-type dementia and Down's syndrome. The Lancet, 2, 39-40.
37. Yates, C. M., Simpson, J., Maloney, A. F. J., Gordon, A., & Reid, A. H. (1980). Alzheimer-like cholinergic deficiency in Down syndrome. The Lancet, 2, 979.
38. Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, O. (1983). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17, 37-49.