메뉴 건너뛰기




Volumn 131, Issue 2, 1997, Pages 130-139

Mecamylamine- or scopolamine-induced learning impairment: Ameliorated by nefiracetam

Author keywords

Aging; Alzheimer's disease; Cognition enhancing; Eyeblink classical conditioning; Memory; Muscarinic receptors; Nicotinic receptors; Nootropic

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; MECAMYLAMINE; MUSCARINIC RECEPTOR; NEFIRACETAM; NICOTINIC RECEPTOR; SCOPOLAMINE;

EID: 0030989567     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050275     Document Type: Article
Times cited : (37)

References (39)
  • 1
    • 0025939057 scopus 로고
    • Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain
    • Abe E (1991) Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain. Psychopharmacology 105:310-316
    • (1991) Psychopharmacology , vol.105 , pp. 310-316
    • Abe, E.1
  • 2
    • 0028177150 scopus 로고
    • Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice
    • Abe E, Murai S, Saito H et al. (1994) Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice. J Neural Transm [Gen Sect] 95:179-193
    • (1994) J Neural Transm [Gen Sect] , vol.95 , pp. 179-193
    • Abe, E.1    Murai, S.2    Saito, H.3
  • 3
    • 0028596018 scopus 로고
    • Cerebellar and brainstem circuits involved in classical eyeblink conditioning
    • Anderson BJ, Steinmetz JE (1994) Cerebellar and brainstem circuits involved in classical eyeblink conditioning. Rev Neurosci 5:251-273
    • (1994) Rev Neurosci , vol.5 , pp. 251-273
    • Anderson, B.J.1    Steinmetz, J.E.2
  • 4
    • 0021321761 scopus 로고
    • Long-term potentiation on hippocampal synaptic transmission affects rate of behavioral learning
    • Berger TW (1984) Long-term potentiation on hippocampal synaptic transmission affects rate of behavioral learning. Science 224:627-630
    • (1984) Science , vol.224 , pp. 627-630
    • Berger, T.W.1
  • 5
    • 0000196748 scopus 로고
    • Role of the hippocampus in classical conditioning of aversive and appetitive behaviors
    • Isaacson RL, Pribram KH (eds) Plenum Press, New York
    • Berger TW, Berry SD, Thompson RF (1986) Role of the hippocampus in classical conditioning of aversive and appetitive behaviors. In: Isaacson RL, Pribram KH (eds) The hippocampus, vol IV. Plenum Press, New York, pp 203-239
    • (1986) The Hippocampus , vol.4 , pp. 203-239
    • Berger, T.W.1    Berry, S.D.2    Thompson, R.F.3
  • 6
    • 8244253732 scopus 로고    scopus 로고
    • Betzing H, Biederman J, Materne C, Neuser V (1980) Pyrrolidin-2-on-1-ylacetic acid 2,6-dimethylanilide, process of preparation and pharmaceutical compositions containing them. German Patent No. DE 2924011
    • Betzing H, Biederman J, Materne C, Neuser V (1980) Pyrrolidin-2-on-1-ylacetic acid 2,6-dimethylanilide, process of preparation and pharmaceutical compositions containing them. German Patent No. DE 2924011
  • 7
    • 0030306522 scopus 로고    scopus 로고
    • On the cerebellum and classical conditioning
    • Daum I, Schugens MM(1996) On the cerebellum and classical conditioning. Cur Dir Psychol Sci 5:58-61
    • (1996) Cur Dir Psychol Sci , vol.5 , pp. 58-61
    • Daum, I.1    Schugens, M.M.2
  • 8
    • 0027210978 scopus 로고
    • Nefiracetam (DM-9384) preserves hippocampal neural cell adhesion molecule-mediated memory consolidation process during scopolamine disruption of passive avoidance training in the rat
    • Doyle E, Regan CM, Shiotani T (1993) Nefiracetam (DM-9384) preserves hippocampal neural cell adhesion molecule-mediated memory consolidation process during scopolamine disruption of passive avoidance training in the rat. J Neurochem 61: 266-272
    • (1993) J Neurochem , vol.61 , pp. 266-272
    • Doyle, E.1    Regan, C.M.2    Shiotani, T.3
  • 9
    • 0021672436 scopus 로고
    • Changes of dopamine metabolism by hypoxia and effect of nootropic drugs
    • Funk KF, Schmidt J (1984) Changes of dopamine metabolism by hypoxia and effect of nootropic drugs. Biomed Biochem Acta 11:1301-1304
    • (1984) Biomed Biochem Acta , vol.11 , pp. 1301-1304
    • Funk, K.F.1    Schmidt, J.2
  • 10
    • 0000727259 scopus 로고
    • Characteristic of learning deficit induced by ibotenic acid lesion of the frontal cortex related with the nucleus basalis of Meynert in rats
    • Nagatsu T, Yoshida M (eds) Plenum Press, New York
    • Hara C, Ogawa N (1990) Characteristic of learning deficit induced by ibotenic acid lesion of the frontal cortex related with the nucleus basalis of Meynert in rats. In: Nagatsu T, Yoshida M (eds) Basic, clinical, and therapeutic aspects of Alzheimer's and Parkinson's disease, vol 1. Plenum Press, New York, pp 735-738
    • (1990) Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease , vol.1 , pp. 735-738
    • Hara, C.1    Ogawa, N.2
  • 11
    • 0004892540 scopus 로고
    • DM-9384, a pyrrolidone derivative, ameliorates basal forebrain lesion-induced amnesia and inhibits cycloheximide-induced decrease in the number of GABA and acetylcholine receptors
    • Nagatsu T, Yoshida M (eds) Plenum Press, New York
    • Kameyama T, Nabeshima T, Tohyama K et al. (1990) DM-9384, a pyrrolidone derivative, ameliorates basal forebrain lesion-induced amnesia and inhibits cycloheximide-induced decrease in the number of GABA and acetylcholine receptors. In: Nagatsu T, Yoshida M (eds) Basic, clinical, and therapeutic aspects of Alzheimer's and Parkinson's diseases, vol 2. Plenum Press, New York, pp 371-374
    • (1990) Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases , vol.2 , pp. 371-374
    • Kameyama, T.1    Nabeshima, T.2    Tohyama, K.3
  • 12
    • 0027344055 scopus 로고
    • Mammalian brain substrates of aversive classical conditioning
    • Lavond DG, Kim JJ, Thompson RF (1993) Mammalian brain substrates of aversive classical conditioning. Annu Rev Psychol 44:317-342
    • (1993) Annu Rev Psychol , vol.44 , pp. 317-342
    • Lavond, D.G.1    Kim, J.J.2    Thompson, R.F.3
  • 13
    • 0020585413 scopus 로고
    • Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system
    • McKinney M, Coyle JT, Hedreen JC (1983) Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. J Comp Neurol 217: 103-111
    • (1983) J Comp Neurol , vol.217 , pp. 103-111
    • McKinney, M.1    Coyle, J.T.2    Hedreen, J.C.3
  • 14
    • 0025039780 scopus 로고
    • Oxiracetam increases the release of endogeneous glutamate from depolarized rat hippocampal slices
    • Marchi M, Besana E, Raiteri M (1990) Oxiracetam increases the release of endogeneous glutamate from depolarized rat hippocampal slices. Eur J Pharmacol 185:247-249
    • (1990) Eur J Pharmacol , vol.185 , pp. 247-249
    • Marchi, M.1    Besana, E.2    Raiteri, M.3
  • 15
    • 0027984961 scopus 로고
    • Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction
    • Nabeshima T (1994) Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction. Drugs Today 30:357-379
    • (1994) Drugs Today , vol.30 , pp. 357-379
    • Nabeshima, T.1
  • 16
    • 0025309740 scopus 로고
    • Effects on DM-9384 in a model of amnesia based on animals with GABA-ergic neuronal dysfunctions
    • Nabeshima T, Noda Y, Tohyama K, Itoh J, Kameyama T (1990) Effects on DM-9384 in a model of amnesia based on animals with GABA-ergic neuronal dysfunctions. Eur J Pharmacol 178:143-149
    • (1990) Eur J Pharmacol , vol.178 , pp. 143-149
    • Nabeshima, T.1    Noda, Y.2    Tohyama, K.3    Itoh, J.4    Kameyama, T.5
  • 18
    • 0025328801 scopus 로고
    • Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordizepoxide-induced amnesia in mice
    • Nabeshima T, Tohyama K, Kameyama T (1991b) Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordizepoxide-induced amnesia in mice. Pharmacol Biochem Behav 36: 233-236
    • (1991) Pharmacol Biochem Behav , vol.36 , pp. 233-236
    • Nabeshima, T.1    Tohyama, K.2    Kameyama, T.3
  • 19
    • 0011338313 scopus 로고
    • DM-9384, a pyrrolidone derivative, protects the membrane dysfunction induced by deprivation of oxygen and glucose in guinea-pig hippocampal neurons in vitro
    • Abst
    • Nakamura J, Higashi H, Nishi S, Nakazawa Y (1991) DM-9384, a pyrrolidone derivative, protects the membrane dysfunction induced by deprivation of oxygen and glucose in guinea-pig hippocampal neurons in vitro. Biol Psychiatry 29 [11 Suppl]: Abst P-29-36
    • (1991) Biol Psychiatry , vol.29 , Issue.11 SUPPL.
    • Nakamura, J.1    Higashi, H.2    Nishi, S.3    Nakazawa, Y.4
  • 20
    • 0011340531 scopus 로고
    • Possible involvement of the activation of calcium channel in the improving effects of nefiracetam (DM-9384) on scopolamine-induced impairment of performance in a passive avoidance task
    • Nakayama S, Yamada K, Shiotani T et al. (1994) Possible involvement of the activation of calcium channel in the improving effects of nefiracetam (DM-9384) on scopolamine-induced impairment of performance in a passive avoidance task. Jpn J Pharmacol 64[Suppl]: 353
    • (1994) Jpn J Pharmacol , vol.64 , Issue.SUPPL. , pp. 353
    • Nakayama, S.1    Yamada, K.2    Shiotani, T.3
  • 21
    • 0024523079 scopus 로고
    • Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384) on learning and memory in rats
    • Sakurai T, Ojima H, Yamasaki T, Kojima H, Akashi A (1989) Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384) on learning and memory in rats. Jpn J Pharmacol 50:47-53
    • (1989) Jpn J Pharmacol , vol.50 , pp. 47-53
    • Sakurai, T.1    Ojima, H.2    Yamasaki, T.3    Kojima, H.4    Akashi, A.5
  • 22
    • 0022576522 scopus 로고
    • 3H]acetylcholine in rat brain
    • 3H]acetylcholine in rat brain. Life Sci 38:2111-2120
    • (1986) Life Sci , vol.38 , pp. 2111-2120
    • Schwartz, R.D.1
  • 24
    • 0020568856 scopus 로고
    • Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure
    • Solomon PR, Solomon SD, Vander Schaaf E, Perry HE (1983) Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure. Science 220:329-331
    • (1983) Science , vol.220 , pp. 329-331
    • Solomon, P.R.1    Solomon, S.D.2    Vander Schaaf, E.3    Perry, H.E.4
  • 25
    • 0022548113 scopus 로고
    • Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: Relation to cholinergic nuclei and projections
    • Spencer DG Jr, Horvath E, Raber J (1986) Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections. Brain Res 380:59-68
    • (1986) Brain Res , vol.380 , pp. 59-68
    • Spencer Jr., D.G.1    Horvath, E.2    Raber, J.3
  • 26
    • 0023181845 scopus 로고
    • Interactions between oxiracetam, quaniracetam and scopolamine on behavior and brain acetylcholine
    • Spignoli G, Pepeu G (1987) Interactions between oxiracetam, quaniracetam and scopolamine on behavior and brain acetylcholine. Pharmacol Biochem Behav 27:491-495
    • (1987) Pharmacol Biochem Behav , vol.27 , pp. 491-495
    • Spignoli, G.1    Pepeu, G.2
  • 27
    • 0001797341 scopus 로고
    • Brain substrates of aversive classical conditioning
    • Madden J IV (ed) Raven Press, New York
    • Steinmetz JE, Thompson RF (1991) Brain substrates of aversive classical conditioning. In: Madden J IV (ed) Neurobiology of learning, emotion and affect. Raven Press, New York, pp 97-120
    • (1991) Neurobiology of Learning, Emotion and Affect , pp. 97-120
    • Steinmetz, J.E.1    Thompson, R.F.2
  • 28
    • 0011291367 scopus 로고
    • Disposition and metabolism of DM-9384, a cyclic GABA derivative, in the rat, dog, and monkey
    • Abstr 32.02.05
    • Sudo K, Hashimoto K, Fujimaki Y, Tachizawa H (1988) Disposition and metabolism of DM-9384, a cyclic GABA derivative, in the rat, dog, and monkey. Psychopharmacology 96 [Suppl.]: Abstr 32.02.05
    • (1988) Psychopharmacology , vol.96 , Issue.SUPPL.
    • Sudo, K.1    Hashimoto, K.2    Fujimaki, Y.3    Tachizawa, H.4
  • 29
    • 0028231217 scopus 로고
    • Organization of memory traces in the mammalian brain
    • Thompson RF, Krupa DJ (1994) Organization of memory traces in the mammalian brain. Annu Rev Neurosci 17:519-549
    • (1994) Annu Rev Neurosci , vol.17 , pp. 519-549
    • Thompson, R.F.1    Krupa, D.J.2
  • 30
    • 0027209321 scopus 로고
    • DM-9384, a new cognition-enhancing agent, increases the turnover of components of the GABAergic system in the rat cerebral cortex
    • Watabe S, Yamaguchi H, Ashida S (1993) DM-9384, a new cognition-enhancing agent, increases the turnover of components of the GABAergic system in the rat cerebral cortex. Eur J Pharmacol 238:303-309
    • (1993) Eur J Pharmacol , vol.238 , pp. 303-309
    • Watabe, S.1    Yamaguchi, H.2    Ashida, S.3
  • 31
    • 84989454036 scopus 로고
    • Evaluation of cognition-enhancing drugs: Utility of the model system of eyeblink classical conditioning
    • Woodruff-Pak DS (1995) Evaluation of cognition-enhancing drugs: utility of the model system of eyeblink classical conditioning. CNS Drug Rev 1:107-128
    • (1995) CNS Drug Rev , vol.1 , pp. 107-128
    • Woodruff-Pak, D.S.1
  • 32
    • 0028352414 scopus 로고
    • Nefiracetam (DM-9384): Effect on classical conditioning in older rabbits
    • Woodruff-Pak DS, Li Y-T (1994) Nefiracetam (DM-9384): effect on classical conditioning in older rabbits. Psychopharmacology 114:200-208
    • (1994) Psychopharmacology , vol.114 , pp. 200-208
    • Woodruff-Pak, D.S.1    Li, Y.-T.2
  • 33
    • 0029891416 scopus 로고    scopus 로고
    • The older rabbit as an animal model: Implications for Alzheimer's disease
    • Woodruff-Pak DS, Trojanowski JQ (1996) The older rabbit as an animal model: implications for Alzheimer's disease. Neurobiol Aging 17:283-290
    • (1996) Neurobiol Aging , vol.17 , pp. 283-290
    • Woodruff-Pak, D.S.1    Trojanowski, J.Q.2
  • 34
    • 0023092269 scopus 로고
    • Classical conditioning in 3-, 30- and 45-month-old rabbits: Behavioral learning and hippocampal unit activity
    • Woodruff-Pak DS, Lavond DG, Logan CG, Thompson RF (1987) Classical conditioning in 3-, 30- and 45-month-old rabbits: behavioral learning and hippocampal unit activity. Neurobiol Aging 8:101-108
    • (1987) Neurobiol Aging , vol.8 , pp. 101-108
    • Woodruff-Pak, D.S.1    Lavond, D.G.2    Logan, C.G.3    Thompson, R.F.4
  • 35
    • 0027960924 scopus 로고
    • The neurotropic compound, BMY 21502, and classical conditioning of the nictitating membrane response in young and older rabbits
    • Woodruff-Pak DS, Coffin JM, Papka M (1994b) The neurotropic compound, BMY 21502, and classical conditioning of the nictitating membrane response in young and older rabbits. Psychobiology 22:312-319
    • (1994) Psychobiology , vol.22 , pp. 312-319
    • Woodruff-Pak, D.S.1    Coffin, J.M.2    Papka, M.3
  • 36
    • 0028341821 scopus 로고
    • Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits
    • Woodruff-Pak DS, Li Y-T, Kazmi A, Kem WR (1994a) Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits. Behav Neurosci 108:486-493
    • (1994) Behav Neurosci , vol.108 , pp. 486-493
    • Woodruff-Pak, D.S.1    Li, Y.-T.2    Kazmi, A.3    Kem, W.R.4
  • 37
    • 0030042148 scopus 로고    scopus 로고
    • Training to criterion in eyeblink classical conditioning in Alzheimer's disease. Down's syndrome with Alzheimer's disease, and healthy elderly
    • Woodruff-Pak DS, Romano S, Papka M (1996) Training to criterion in eyeblink classical conditioning in Alzheimer's disease. Down's syndrome with Alzheimer's disease, and healthy elderly. Behav Neurosci 110:22-29
    • (1996) Behav Neurosci , vol.110 , pp. 22-29
    • Woodruff-Pak, D.S.1    Romano, S.2    Papka, M.3
  • 38
    • 0031039999 scopus 로고    scopus 로고
    • Hippocampus in delay eyeblink classical conditioning: Essential for nefiracetam amelioration of leaning in older rabbits
    • in press
    • Woodruff-Pak DS, Li Y-T, Hinchliffe RM, Port RL (1997) Hippocampus in delay eyeblink classical conditioning: essential for nefiracetam amelioration of leaning in older rabbits. Brain Res (in press)
    • (1997) Brain Res
    • Woodruff-Pak, D.S.1    Li, Y.-T.2    Hinchliffe, R.M.3    Port, R.L.4
  • 39
    • 0028297182 scopus 로고
    • Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-14 cells
    • Yoshii M, Watabe S (1994) Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-14 cells. Brain Res 642:123-131
    • (1994) Brain Res , vol.642 , pp. 123-131
    • Yoshii, M.1    Watabe, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.