Substrate-dependent proton load and recovery of stunned hearts during pyruvate dehydrogenase stimulation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 1 48-1, 2000, Pages

  Griffin, Julian L ^a   White, Lawrence T ^a   Lewandowski, E Douglas ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Dichloroacetate; Myocardium; Nuclear magnetic resonance spectroscopy; Reperfusion

Indexed keywords

PYRUVATE DEHYDROGENASE;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; CELL PH; ENZYME ACTIVATION; HEART FAILURE; HEART MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RABBIT; STUNNED HEART MUSCLE;

EID: 0033853217     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.1.h361     Document Type: Article

References (36)

1. Acute cardiac ischemia and reperfusion: Contractility, relaxation, and glycolysis
2. Dichloroacetate as metabolic therapy for myocardial ischemia and failure
3. Improved hemodynamic function and mechanical effeciency in congestive heart failure with sodium dichloroacetate
4. Is lactate-induced myocardial ischaemic injury mediated by decreased pH or increased intracellular lactate?
5. Chemical versus isotopic equilibrium and the metabolic fate of glycol lytic end products in the heart
6. Preferential uptake of lactate by the normal myocardium in dogs
7. Assessment of glycogen turnover in aerobic, ischemic, and reperfused working rat hearts
8. Fatty acid metabolism and contractile function in the reperfused myocardium
9. Regulation of pyruvate dehydrogenase in rat heart
10. Effects of ischaemia and reperfusion on pyruvate dehydrogenase activity in isolated rat hearts
11. 2+ ](i) elevation and ATP depletion
12. Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate
13. NMR studies of β-oxidation and short chain fatty acid metabolism during recovery of reperfused hearts
14. Cardiac responses to induced lactate oxidation: NMR analysis of metabolic equilibria
15. 31P NMR analyses
16. Pyruvate dehydrogenase influences postischemic heart function
17. 2 during reperfusion of ischemic hearts
18. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons
19. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts
20. Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by 13C NMR spectroscopy
21. Determination of intracellular pH by 31P magnetic resonance
22. Metabolic responses of the heart in acute myocardial infarction in man
23. Amiloride delays the ischemia-induced rise in cytosolic free calcium
24. The kinetics of transport of lactate and pyruvate into isolated cardiac myocytes from guinea pig
25. +
26. Fasting in vivo delays myocardial cell damage after brief of ischemia in the isolated working rat heart
27. Calcium and the oxygen paradox
28. Rating of perceived exertion and blood lactate concentration during submaximaI running
29. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart
30. 2+ overload and depressed recovery of ventricular function of reperfused rat hearts
31. Cytosolic redox state mediates postischemic dehydrogenase stimulation
32. Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate
33. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
34. Effect of dichloroacetate on the exercise performance of patients with heart failure