Chemical genomics; Chemistry; Drugs; Genomics; Therapy
Indexed keywords
BIOINFORMATICS;
BIOTECHNOLOGY;
CHEMICAL GENOMICS;
COMBINATORIAL CHEMISTRY;
DNA MICROARRAY;
DRUG DEVELOPMENT;
DRUG SCREENING;
DRUG TARGETING;
GENOMICS;
HUMAN GENOME;
PROTEOMICS;
REVIEW;
ANIMAL;
CHEMISTRY;
HUMAN;
METHODOLOGY;
PHARMACEUTICS;
Chemical genomics: What will it take and who gets to play?
MacBeath G: Chemical genomics: What will it take and who gets to play? Genome Biol (2001) 2:2005.1-2005.6. This review explains the current issue of several drug targets and how smaller, faster and cheaper tools can be used for screening small molecules. This article also discusses how proteins and expression technologies can be utilized in the drug discovery process.
Chemical genomics: A new paradigm for drug discovery
Bolten BM, Lenz GR: Chemical genomics: A new paradigm for drug discovery. Spectrum Drug Discovery Design (2001) http://www.dresources.com/dr/Reports.nsf/BrowseAbstracts/AE0D0E25 CA07DBB886256A1F006BBDE5?OpenDocument This review discusses how the genomics revolution brings new challenges to drug discovery and development. A detailed description is given of the current drug discovery paradigm and chemical genomics approach to drug discovery. The way in which bioinformatics and transcription profiling can be integrated into chemical genomics-based drug discovery is also discussed.
Towards high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age
Arya P, Joseph R, Chou DT: Towards high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age. Chem Biol (2002) 9:145-156.
Liszewski K: Chemical genomics advances. Genet Eng News (2002) 22:73-76. This news article gives a detailed and up-to-date description of the field of chemical genomics. Several chemical genomics companies and their tools and technologies are discussed in detail.
