The use of chemical design tools to transform proteomics data into drug candidates

BioTechniques

Volumn 32, Issue 3 SUPPL., 2002, Pages

  Dean, Philip M ^a   Zanders, Edward D ^a  

^a De Novo Pharmaceuticals   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER AIDED DESIGN; DRUG PRODUCTS; GENES; MEDICINE; PRODUCT DESIGN; PROTEINS; SILICON; STRUCTURE (COMPOSITION);

DESIGN TOOLS;

BIOTECHNOLOGY;

PROTEOME;

ARTICLE; BIOINFORMATICS; BIOTECHNOLOGY; COMBINATORIAL LIBRARY; DRUG DESIGN; DRUG TARGETING; GENOMICS; HYDROGEN BOND; MEDICAL GENETICS; PROTEIN STRUCTURE; PROTEOMICS; CHEMISTRY; COMBINATORIAL CHEMISTRY; HUMAN; METHODOLOGY; REVIEW;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HUMANS; PROTEOME;

EID: 0036006431     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/mar0204     Document Type: Article

References (13)

1. Protein structure prediction and structural genomics
2. The art and practice of structure-based drug design: A molecular modelling perspective
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4. Industrial-scale, genomics-based drug design and discovery
5. Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modelling program SLATE
6. Initial sequencing and analysis of the human genome
7. Gene duplications in the structural evolution of chymotrypsin
8. An automated method for predicting the positions of hydrogen-bonding atoms in binding sites
9. SLATE: A method for the superposition of flexible ligands
10. Crystal structure of rhodopsin: A G protein-coupled receptor
11. Comparative protein modelling by satisfaction of spatial restraints
12. Evaluation of a method for controlling molecular scaffold diversity in de novo ligand design
13. The sequence of the human genome