Two-dimensional electrophoresis of liver proteins: Characterization of a drug-induced hepatomegaly in rats

Electrophoresis

Volumn 21, Issue 11, 2000, Pages 2122-2128

  Newsholme, Stephen J ^a   Maleeff, Beverly F ^a   Steiner, Sandra ^b   Anderson, N Leigh ^b   Schwartz, Lester W ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Large Scale Biology Corporation   (United States)

Author keywords

Acute phase reactants; Hepatocellular proliferation; Hepatomegaly; Pyrimidine derivative; Rat liver; Two dimensional polyacrylamide gel electrophoresis

Indexed keywords

AMINO ACIDS; AROMATIC COMPOUNDS; BIOSYNTHESIS; CELL MEMBRANES; CELL PROLIFERATION; CONTROLLED DRUG DELIVERY; ELECTROPHORESIS; MOLECULAR BIOLOGY; RATS;

ACUTE-PHASE REACTANT; HEPATOCELLULAR; HEPATOCELLULAR PROLIFERATION; HEPATOMEGALY; METHIONINE; PROTEIN CHARACTERIZATION; PYRIMIDINE DERIVATIVES; RAT LIVERS; TWO DIMENSIONAL ELECTROPHORESIS; TWO-DIMENSIONAL POLYACRYLAMIDE GEL ELECTROPHORESIS;

PROTEINS;

LIVER PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; DISEASE ACTIVITY; FEMALE; GENE MAPPING; HEPATOMEGALY; IMMUNOHISTOCHEMISTRY; NONHUMAN; RAT; SEQUENCE ANALYSIS; TWO DIMENSIONAL ELECTROPHORESIS;

EID: 0033920376     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/1522-2683(20000601)21:11<2122::aid-elps2122>3.0.co;2-%23     Document Type: Conference Paper

References (19)

1. Anderson, N. L., Esquer-Blasco, R., Hofmann, J.-P., Meyhaus, L., Raymackers, J., Steiner, S., Witzmann, F., Anderson, N. G., Electrophoresis 1995, 16, 1977-1981.
2. Anderson, N. L., Taylor, J., Hofmann, J.-P., Esquer-Blasco, R., Swift, S., Anderson, N. G., Toxicol. Pathol. 1996, 24, 72-76.
3. Newsholme, S. J., Maleeff, B. E., Anderson, N. L., Schwartz, L., Toxicol. Sci. 1998, 42, 368.
4. Schulte-Hermann, R., CRC Crit. Rev. Toxicol. 1974, 33, 97-1974.
5. Massey, E. D., Butler, W. H., Chem. Biol. Interact. 1978, 24, 329-344.
6. Reddy, J. K., Lalwini, N. D., CRC Crit. Rev. Toxicol. 1983, 12, 1-58.
7. Reddy, J. K., Warren, J. R., Reddy, M. K., Lalwini, N. D., Ann. N. Y. Acad. Sci. 1982, 386, 81-110.
8. National Research Council, Guide for the Care and Use of Laboratory Animals, National Academy Press, Washington, DC 1996.
9. Eldridge, S. R., Tilbury, L. F., Goldsworthy, T. L., Butterworth, E. B., Carcinogenesis 1990, 11, 2245-2251.
10. Foley, J. F., Ton, T., Maronpot, R. R., Butterworth, B., Goldworthy, T. L., Environ Health Perspect. 1993, 101, 199-206.
11. Eldridge, S. R., Butterworth, B. E., Goldworthy, T. L., Environ. Health Perspect. 1993, 101, 211-218.
12. Anderson, N. L., Two-Dimensional Electrophoresis Operation of the ISO-DALT System, Large Scale Biology Press Washington, DC 1998, pp. 1-170.
13. Anderson, N. L., Esquer-Blasco, R., Hofmann, J.-P., Anderson, N. G., Electrophoresis 1991, 12, 907-930.
14. Arce, A., Aicher, L., Wahl, D., Anderson, N. L., Meheus, L., Raymackers, J., Cordier, A., Steiner, S., Life Sci. 1998, 63, 2243-2250.
15. Parker, G. L., Orton, T. C., in: Gustafsson, J. A., Carlstedt-Duke, J., Mode, A., Rafter, J. (Eds.), Biochemistry, Biophysics and Regulation of Cytochrome P-450, Elsevier/North Holland Biomedical Press, Amsterdam 1980, p. 373.
16. Kordula, T., Bugno, M., Lason, W., Przewlocki, R., Koj, A., Biochem. Biophys. Res. Commun. 1994, 201, 222-227.
17. Scotte, M., Masson, S., Lyoumi, S., Hiron, M., Teniere, P., Lebreton, J. P., Daveau, M., Cytokine 1997, 9, 859-867.
18. Frago, L. M., Giminez, A., Rodriquez, E. N., Varela-Nieto, I., FEBS Lett. 1998, 426, 305-308.
19. Abbott, A., Nature 1999, 402, 715-720.