Simultaneous measurement of hundreds of liver proteins: Application in assessment of liver function

Toxicologic Pathology

Volumn 24, Issue 1, 1996, Pages 72-76

  Anderson, N Leigh ^a   Taylor, John ^a   Hofmann, Jean Paul ^a   Esquer Blasco, Ricardo ^a   Swift, Susan ^a   Anderson, Norman G ^a  

^a Large Scale Biology Corporation   (United States)

Author keywords

2 dimensional electrophoresis; mechanism; molecular pathology; Protein mapping

Indexed keywords

LIVER PROTEIN; MEPYRAMINE; METHAPYRILENE; OLTIPRAZ;

ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; HUMAN; LIVER DISEASE; LIVER FUNCTION; LIVER TOXICITY; MOUSE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; RAT; TOXICOLOGY;

EID: 0030023174     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400110     Document Type: Conference Paper

References (8)

1. Anderson L, Steele VK, Kelloff GJ, and Sharma S (1995). Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver. J. Cell. Biochem. Suppl. 22: 108-116.
2. Anderson NG and Anderson NL (1978). Analytical techniques for cell fractions. XXI. Two-dimensional analysis of serum and tissue proteins: Multiple isoelectric focusing. Anal. Biochem. 85: 331-340.
3. Anderson NL and Anderson NG (1978). Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: Multiple gradient-slab electrophoresis. Anal. Biochem. 85: 341-354.
4. Anderson NL, Copple DC, Bendele RA, Probst GS, and Richardson FC (1992). Covalent protein modifications and gene expression changes in rodent liver and hepatocyte systems following administration of methapyrilene: A study using two-dimensional electrophoresis. Fund. Appl. Toxicol 18: 570-580.
5. Anderson NL, Esquer-Blasco R, Hofmann J-P, and Anderson NG (1991). A two-dimensional gel database of rat liver proteins useful in gene regulation and drug effects studies. Electrophoresis 12: 907-930.
6. Anderson NL, Giere FA, Nance SL, Gemmell MA, Tollaksen SL, and Anderson NG (1986). Differences between 2-D electrophoretic protein patterns of livers of male and female mice. In: Progrès Récents en Electrophorèse Bidimensionelle, M-M Galteau and G Siest (eds). Presses Universitaires de Nancy, Nancy, pp. 253-260.
7. Cunningham ML, Pippin LL, Anderson NL, and Wenk ML (1995). The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13 week feed study. Toxicol. Appl. Pharmacol. 131: 216-222.
8. Richardson, FC, Strom SC, Copple DM, Bendele RA, Probst GS, and Anderson NL (1993). Comparisons of protein changes in human and rodent hepatocytes induced by the rat-specific carcinogen, methapyrilene. Electrophoresis 14: 157-161.