Isolation and characterization of the monkey UGT2B30 gene that encodes a uridine diphosphate-glucuronosyltransferase enzyme active on mineralocorticoid, glucocorticoid, androgen and oestrogen hormones

Biochemical Journal

Volumn 365, Issue 1, 2002, Pages 213-222

  Girard, Caroline ^a   Barbier, Olivier ^a   Turgeon, David ^a   Bélanger, Alain ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Genomic structure; Glucuronidation; Glycosyltransferase; Relative activity; Steroid metabolism

Indexed keywords

CELLS; DNA; HORMONES; PROTEINS; TISSUE;

ISOFORMS;

GENES;

ANDROGEN; ANDROSTANEDIOL; ANDROSTANOLONE; ANDROSTERONE; ESTROGEN; GENE PRODUCT; GLUCOCORTICOID; GLUCURONOSYLTRANSFERASE; MINERALOCORTICOID; PROTEIN UGT2B30; TETRAHYDROCORTISONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION; GENE ISOLATION; GENETIC CODE; GENETIC TRANSCRIPTION; GLUCURONIDATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANDROGENS; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; ESTROGENS; EXONS; FEMALE; GLUCOCORTICOIDS; GLUCURONOSYLTRANSFERASE; INTRONS; MACACA FASCICULARIS; MALE; MINERALOCORTICOIDS; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TISSUE DISTRIBUTION;

MACACA FASCICULARIS; SIMIAE;

EID: 0036646538     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20011594     Document Type: Article

References (49)

1. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
2. UDP-glucuronosyltransferases: A family of detoxifying enzymes
3. Roles of UDP-glucuronosyltransferases in chemical carcinogenesis
4. Characterization of UDP-glucuronosyltransferases active on steroid hormones
5. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
6. Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members
7. 19 steroids
8. Determination of nonconjugated and conjugated steroid levels in plasma and prostate after separation on C-18 columns
9. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
10. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8
11. 19 steroid glucuronides in primates, rodents, and domestic animals
12. Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey
13. Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens
14. Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone
15. Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid conjugating protein
16. UGT2B23, a novel UDP-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites
17. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
18. Specificity of glucuronosyltransferase activity in the human cancer cell line LNCaP, evidence for the presence of at feast two glucuronosyltransferase enzymes
19. Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase
20. Codon 367 polymorphism of the human type I 3 beta-hydroxysteroid dehydrogenase/isomerase gene (HS5DB3)
21. Organization and expression of eucaryotic split genes coding for proteins
22. Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells
23. Isolation, sequence, and developmental expression of rat UGT2B2: The gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone
24. Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter
25. Isolation and characterization of the human UGT2B7 gene
26. Isolation and Characterization of the Human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on cheromosome 4
27. Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme
28. Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation
29. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-grucuronosyrtransferase isozymes with identical carboxyl termini
30. The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1
31. cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3
32. The monkey and human uridine diphosphate-glucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes
33. Studies on steroid conjugates-VIII. Isolation and characterization of glucuronide-conjugated metabolites of cortisol in human urine
34. Studies on steroid conjugates: IX. Urinary excretion of sulfate conjugated metabolites of cortisol in man
35. The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization
36. Cushing's syndrome: From patients to proteins
37. Urinary free cortisol and cortisone determined by high performance liquid chromatography in the diagnosis of Cushing's syndrome
38. The urinary excretion of glucosiduronates of cortisol and cortisone
39. The characterization of polar corticosteroids in the urine of the macaque monkey (Macaca fascicularis) and the baboon (Papio hamadryas)
40. The regio- and stereo-selectivity of C19 and C21 hydroxysteroid glucuronidation by UGT2B7 and UGT2B11
41. Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
42. Intracrinology
43. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates
44. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily
45. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11
46. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms
47. Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens
48. Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol
49. Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols