Capsaicin and carbon dioxide act by distinct mechanisms on sensory nerve terminals in the cat cornea

Pain

Volumn 70, Issue 1, 1997, Pages 23-29

  Chen, Xiaojie ^a   Belmonte, Carlos ^a   Rang, Humphrey P ^b  

^a UNIVERSITY OF ALICANTE   (Spain)

^b Sandoz Institute for Medical Research   (United Kingdom)

Author keywords

capsaicin; capsazepine; carbon dioxide; corneal afferent fibres; desensitisation

Indexed keywords

CAPSAICIN; CAPSAZEPINE; CARBON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; CONTROLLED STUDY; CORNEA; DESENSITIZATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE;

EID: 0030963369     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(96)03256-3     Document Type: Article

References (31)

1. Belmonte, C., Gallar, J., Pozo, M.A. and Rebollo, I., Excitation by irritant chemical substances of sensory afferent units in the cat's cornea, J. Physiol., 437 (1991) 709-725.
2. Belmonte, C. and Giraldez, F., Response of cat sensory receptors to mechanical and thermal stimulation, J. Physiol., 321 (1981) 355-368.
3. Bevan, S.J. and Docherty, R.J., Cellular mechanisms of the action of capsaicin. In: J.N. Wood (Ed.), Capsaicin in the Study of Pain, Academic Press, London, 1993, pp. 27-44.
4. Bevan, S. and Geppetti, P., Protons: small stimulants of capsaicin-sensitive sensory nerves, Trends Neurosci., 17 (1994) 509-512.
5. Bevan, S. and Yeats, J., Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones, J. Physiol., 433 (1991) 145-161.
6. Bevan, S., Hothi, S., Hughes, G., James, I.E., Rang, H.P., Shah, K., Walpole, C.S J. and Yeats, J.C., Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin, Br. J. Pharmacol., 107 (1992a) 544-552.
7. Bevan, S., Shah, K. and Rang, H.P., Capsazepine does not block the proton-induced activation of rat sensory neurons, Br. J. Pharmacol., 107 (1992b) pp. 235.
8. Blumberg, P., Szallasi, A. and Acs, G., Resiniferatoxin - an ultrapotent capsaicin analogue. In: J.N. Wood (Ed.), Capsaicin in the Study of Pain, Academic Press, London, 1993, pp. 45-62.
9. Bonnano, J.A. and Poise, K.A., Measurement of in vivo human corneal stromal pH: open and closed eyes. Invest. Ophthalmol. Vis. Sci., 28 (1987), 522-530.
10. 2 stimulation of the cornea: a comparison between human sensation and nerve activity in polymodal nociceptive afferents of the cat, Eur. J. Neurosci., 7 (1995) 1154-1163.
11. Cholewinski, A., Burgess, G.M. and Bevan, S., The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons, Neuroscience, 55 (1993) 1015-1023.
12. Cochet, P. and Bonnet, R., L'esthesie cornéenne, Clin. Ophthalmol., 4 (1963) 1-27.
13. Dray, A., Mechanism of action of capsaicin-like molecules on sensory neurons. Life Sci., 51 (1992) 1759-1765.
14. Dray, A., Patel, I., Naeem, S., Rueff, A. and Urban, L., Studies with Capsazepine on peripheral nociceptor activation by capsaicin and low pH: evidence for a dual effect of capsaicin, Br. J. Pharmacol., 107 (1992) 236.
15. Fox, A.J., Urban, L., Barnes, P.J. and Dray, A., Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway c-fibres and vagus nerve from the guinea-pig, Neuroscience, 67 (1995) 741-752.
16. Franco-Cereceda, A. and Lundberg, J.M., Capsazepine inhibits low pH- and lactic acid-evoked release of calcitonin gene-related peptide from sensory nerves in guinea-pig heart, Eur. J. Pharmacol., 221 (1992) 183-184.
17. Franco-Cereceda, A., Kallner, G. and Lundberg, J.M., Capsazepine-sensitive release of calcitonin gene-related peptide from C-fibre afferents in the guinea-pig heart by low pH and lactic acid, Eur. J. Pharmacol., 238 (1993) 311-316.
18. Franco-Cereceda, A., Kallner, G. and Lundberg, J.M., Cyclo-oxygenase products released by low pH have capsaicin-like actions on sensory nerves in the isolated guinea pig heart, Cardiovasc. Res., 28 (1994) 365-369.
19. Gallar, J., Pozo, M.A., Tuckett, R.P. and Belmonte, C., Response of sensory units with unmyelinated fibres to mechanical, thermal and chemical stimulation of the cat's cornea, J. Physiol., 468 (1993) 609-622.
20. Garcia-Hirschfeld, J., López-Briones, L.G., Belmonte, C. and Valdeolmillos, M., Intracellular free calcium responses to protons and capsaicin in cultured trigeminal neurons, Neuroscience, 67 (1995) 234-235.
21. Lee, L.Y. and Lundberg, J.M., Capsazepine abolishes pulmonary chemoreflexes induced by capsaicin in anesthetized rats, J. Appl. Physiol., 76 (1994) 1848-1855.
22. Lou, Y.P., Regulation of neuropeptide release from pulmonary capsaicin-sensitive afferents in relation to bronchoconstriction, Acta Physiol. Scand., 612 (Suppl.) (1993) 1-88.
23. Lou, Y.P. and Lundberg, J.M., Inhibition of low pH-evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist, Biochem. Biophys. Res. Comm., 189 (1992) 537-544.
24. Maggi, C.A., Bevan, S.J., Walpole, C.S.J., Rang, H.P. and Giulani, S., A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens, Br. J. Pharmac., 108 (1993) 801-805.
25. Rang, H.P., Bevan, S. and Dray, A., Chemical activation of nociceptive peripheral neurones. In: J.C.D. Wells and C.J. Woolf (Eds.), Pain Mechanisms and Management, The British Council, London, 1991, pp. 534-548.
26. Rang, H.P., Bevan, S.J. and Dray, A., Nociceptive peripheral neurons: cellular properties. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill-Livingstone, Edinburgh, 1994, pp. 57-78.
27. Santicoli, P., Del Bianco, E., Figini, M., Bevan, S. and Maggi, C.A., Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH, capsaicin and potassium in the rat soleus muscle, Br. J. Pharmacol., 110 (1993) 609-612.
28. Satoh, H., Lou, Y. and Lundberg, J.M., Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guineapigs, Eur. J. Pharmacol., 236 (1993) 367-372.
29. Steen, K.H., Reeh, P.W., Anton, F. and Handwerker, H.O., Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro, J. Neurosci., 12 (1992) 86-95.
30. Walpole, C.S., Bevan, S., Bovermann, G., Boelsterli, J., Breckenridge, R., Davies, J.W., Hughes, G.A., James, I.E., Oberer, L. and Winter, J., The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin, J. Med. Chem., 37 (1994) 1942-1954.
31. Wood, J.N., Winter, J., James, I.E., Rang, H.P., Yeats, J. and Bevan, S., Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture., J. Neurosci., 8 (1988) 3208-3220.