Haplotype exclusion: The unique case presented by multiple immunoglobulin gene loci in cartilaginous fish

Seminars in Immunology

Volumn 14, Issue 3, 2002, Pages 145-152

  Eason, Donna D ^a   Litman, Gary W ^a,b,c  

^a JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Cartilaginous fish; Gene clusters; Germline joined genes; Single cell PCR; Transcriptional control

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ALLELIC EXCLUSION; ARTICLE; DNA METHYLATION; ELASMOBRANCHII; FISH; GENE CLUSTER; GENE EXPRESSION; GENE LOCUS; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HAPLOTYPE; IMMUNOGLOBULIN GENE; NONHUMAN; OLFACTORY RECEPTOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; ALLELE; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; COMPARATIVE STUDY; GENETICS; HUMAN; IMMUNOLOGY; MULTIGENE FAMILY; REVIEW; SPECIES DIFFERENCE;

ALLELES; ANIMALS; ANTIBODY DIVERSITY; FISHES; GENES, IMMUNOGLOBULIN; HAPLOTYPES; HUMANS; MODELS, IMMUNOLOGICAL; MULTIGENE FAMILY; RECEPTORS, ODORANT; SPECIES SPECIFICITY;

EID: 0036617030     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-5323(02)00038-6     Document Type: Article

References (54)

1. Evolution of antigen binding receptors
2. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
3. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
4. Lack of heterogeneity in anti-hapten antibodies of a phylogenetically primitive shark
5. The range and fine specificity of the anti-hapten immune response: Phylogenetic studies
6. Antibody response in Heterodontus
7. H segmental elements during vertebrate evolution
8. H gene structure and diversity in Heterodontus, a phylogenetically primitive shark
9. H gene loci in a primitive vertebrate
10. Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate
11. Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes
12. Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity
13. Extensive families of constant region genes in a phylogenetically primitive vertebrate indicate an additional level of immunoglobulin complexity
14. Immunoglobulin heavy chain gene organization and complexity in the skate, Raja erinacea
15. Two distinct immunoglobulin heavy chain isotypes in a primitive cartilaginous fish, Raja erinacea
16. Complete genomic sequence and patterns of transcription of a member of an unusual family of closely related, chromosomally dispersed immunoglobulin gene clusters in Raja
17. Complex expression patterns of lymphocyte-specific genes during the development of cartilaginous fish implicate unique lymphoid tissues in generating an immune repertoire
18. A new high molecular weight immunoglobulin class from the carcharhine shark: Implications for the properties of the primordial immunoglobulin
19. A novel 'chimeric' antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin
20. A long form of the skate IgX gene exhibits a striking resemblance to the new shark IgW and IgNARC genes
21. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
22. Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins
23. Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: Possible role in antigen-driven reactions in the absence of germinal centers
24. Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: The translation synthesis model of somatic hypermutation
25. Genomic organization and sequences of immunoglobulin light chain genes in a primitive vertebrate suggest coevolution of immunoglobulin gene organization
26. Immunoglobulin light chain class multiplicity and alternative organizational forms in early vertebrate phylogeny
27. The generation of immunoglobulin light chain gene diversity in Raja erinacea is not associated with somatic rearrangement, an exception to a central paradigm of B cell immunity
28. The structure and organization of immunoglobulin genes in lower vertebrates
29. Evolutionary development of the B cell repertoire
30. Genomic clone for the sandbar shark lambda light chain: Generation of diversity in the absence of gene rearrangement
31. Rearrangement of immunoglobulin genes in shark germ cells
32. Development and characterization of channel catfish long term B cell lines
33. Immune-type diversity in the absence of somatic rearrangement
34. A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG
35. Toward a layered immune system
36. The phylogenetic development of the cells that express, and the mechanisms that diversify, immunoglobulins and T cell antigen receptors
37. Ontogenetic studies on the appearance of two classes of immunoglobulin-forming cells in the spleen of the Aleutian skate, Bathyraja aleutica, a cartilaginous fish
38. The Protecton: The unit of humoral immunity selected by evolution
39. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
40. A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
41. Identification of candidate Drosophila olfactory receptors from genomic DNA sequence
42. Olfaction in birds: Differential embryonic expression of nine putative ordorant receptor genes in the avian olfactory system
43. The family of genes encoding odorant receptors in the channel catfish
44. Olfactory receptor gene cluster on human chromosome 17: Possible duplication of an ancestral receptor repertoire
45. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: Recombinatorial events affecting receptor diversity
46. Large multi-chromosomal duplications encompass many members of the olfactory receptor gene family in the human genome
47. Primate evolution of an olfactory receptor cluster: Diversification by gene conversion and recent emergence of pseudogenes
48. A zonal organization of odorant receptor gene expression in the olfactory epithelium
49. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium
50. Allelic inactivation regulates olfactory receptor gene expression
51. Genomic analysis of orthologous mouse and human olfactory receptor loci
52. Mutually exclusive expression of odorant receptor transgenes
53. Kappa chain monoallelic demethylation and the establishment of allelic exclusion
54. Allelic exclusion in B and T lymphopoiesis