A novel mechanism for mitogenic signaling via pro-transforming growth factor α within hepatocyte nuclei

Hepatology

Volumn 35, Issue 6, 2002, Pages 1372-1380

  Grasl Kraupp, Bettina ^a   Schausberger, Elisabeth ^a   Hufnagl, Karin ^a   Gerner, Christopher ^a   Low Baselli, Alexandra ^a   Rossmanith, Walter ^a   Parzefall, Wolfram ^a   Schulte Hermann, Rolf ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYPROTERONE ACETATE; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; PROSTAGLANDIN E2; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CLINICAL PATHWAY; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOLOGY; LIVER CELL NUCLEUS; LIVER CIRRHOSIS; LIVER RESECTION; MALE; MASS SPECTROMETRY; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0036614697     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2002.33203     Document Type: Article

References (50)

1. Transforming growth factor α
2. Transforming growth factor α. A model for membrane-anchored growth factors
3. Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met, TGF-β receptor type II, and p53 expression in human hepatocellular carcinomas
4. Concomitant and isolated expression of TGFα and EGF-R in human hepatoma cells supports the hypothesis of autocrine, paracrine, and endocrine growth of human hepatoma
5. Tyrosine kinase inhibition: An approach to drug development
6. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner
7. Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy
8. Liver regeneration
9. Active cell death (apoptosis) in liver biology and disease
10. Quantitation of multistage carcinogenesis in rat liver
11. Inhibition of tumor growth in liver epithelial cells transfected with a transforming growth factor α antisense gene
12. Differential dependence of the tumorigenicity of chemically transformed rat liver epithelial cells on autocrine production of transforming growth factor α
13. Intrahepatic distribution of transforming growth factor-alpha (TGFα) during liver regeneration following carbon tetrachloride-induced necrosis
14. Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone
15. Immunohistochemical localization of transforming growth factor alpha in chemically induced rat hepatocellular carcinomas with reference to differentiation and proliferation
16. The role of apoptosis in hepatocarcinogenesis
17. Nuclear signaling pathways for polypeptide ligands and their membrane receptors?
18. Nuclear co-localization and complex formation of insulin with retinoblastoma protein in HepG2 human hepatoma cells
19. Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting
20. Nuclear translocation of fibroblast growth factor (fgf) receptors in response to FGF-2
21. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells
22. Expression of basic fibroblast growth factor like immunoreactivity in the nuclei of regenerating hepatocytes
23. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1
24. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver
25. Inherent increase of apoptosis in liver tumors: Implications for carcinogenesis and tumor regression
26. Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia
27. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal
28. Initiated rat hepatocytes in primary culture: A novel tool to study alterations in growth control during the first stage of carcinogenesis
29. Characterization of the rat transforming growth factor alpha gene and identification of promoter sequences
30. Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions
31. Isolation of nuclei from rat liver and other tissues
32. Similarity between nuclear matrix proteins of various cells revealed by an improved isolation method
33. The fas-induced apoptosis analyzed by high throughput proteome analysis
34. Enhancement of peroxisomal enzymes, cytochrome P-452 and DNA synthesis in putative preneoplastic foci of rat liver treated with the peroxisome proliferator nafenopin
35. Differential expression of transforming growth factor alpha, adhesion molecules and integrins in primary, metastatic liver tumors and in liver cirrhosis
36. Quantitative analysis of tumor initiation in rat liver: Role of cell replication and cell death (apoptosis)
37. Transmembrane TGFα precursors activate EGF/TGFα receptors
38. Biologically active precursor for transforming growth factor type α, released by retrovirally transformed cells
39. Abundant TGFα precursor and EGF receptor expression as a possible mechanism for the preferential growth of carcinogen-induced preneoplastic and neoplastic hepatocytes in rats
40. Transforming growth factor α (TGFα) concentrations increase in regenerating liver: Evidence for a delayed accumulation of mature TGFα
41. Characterization of high molecular weight transforming growth factor α in a breast cancer cell line
42. Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-α mRNA, encoding precursors lacking carboxy-terminal valine residues
43. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-α to the cell surface
44. The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-α and membrane type matrix metalloprotease (MT1-MMP)
45. Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins with translocation of epidermal growth factor receptor into the nucleus
46. Translocation of epidermal growth factor to the hepatocyte nucleus during rat liver regeneration
47. Localization of epidermal growth factor receptor in hepatocyte nuclei
48. A different localization of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix
49. Transforming growth factor α enhances cyclin D1 transcription through the binding of early growth response proteins to a cis-regulatory element in the cyclin D1 promoter
50. Myc downregulation by transforming growth factor β required for activation of the p15(Ink4b) G1 arrest pathway