"In vivo" toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the presence of a glutamine-rich region in its intracellular domain

Anais da Academia Brasileira de Ciencias

Volumn 74, Issue 2, 2002, Pages 285-295

  Machado, Ricardo C ^a   Pereira, Rodrigo N R ^a   Costa, Mara S A ^a   Ramos, Ricardo Guelerman P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cell death; Drosophila; Glutamine rich repeats; Rst irreC

Indexed keywords

DROSOPHILA MELANOGASTER; INSECTA; MELANOGASTER;

AMINO ACID; DROSOPHILA PROTEIN; EYE PROTEIN; GLUTAMINE; INSECT PROTEIN; NERVE CELL ADHESION MOLECULE; ROUGHEST PROTEIN, DROSOPHILA;

ANIMAL; APOPTOSIS; ARTICLE; CELL DEATH; CHEMISTRY; DROSOPHILA; DRUG EFFECT; FEMALE; GENETICS; LARVA; METABOLISM; PHYSIOLOGY; PLASMID;

AMINO ACIDS; ANIMALS; APOPTOSIS; CELL ADHESION MOLECULES, NEURONAL; CELL DEATH; DROSOPHILA; DROSOPHILA PROTEINS; EYE PROTEINS; FEMALE; GLUTAMINE; INSECT PROTEINS; LARVA; PLASMIDS;

EID: 0036598597     PISSN: 00013765     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0001-37652002000200007     Document Type: Article

References (39)

1. ASHBURNER M. 1989. Drosophila. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. p. 402.
2. ASHKENAZI A AND DIXIT VM. 1998. Death receptors: signaling and modulation. Science 281: 1305-1308.
3. BOSCHERT U, RAMOS RGP, TIX S, TECHNAU G AND FISCHBACH K-F. 1990. Genetic and developmental analysis of irreC, a genetic function required for optic chiasm formation in Drosophila. J Neurogenet 6: 153-171.
4. COUREY AJ AND TJIAN R. 1988. Analysis of Sp1 in vivo reveals multiple transcription domains, including a novel glutamine-rich activation motif. Cell 55: 887-898.
5. COUREY AJ, HOLTZMAN DA, JACKSON SP AND TJIAN R. 1989. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59: 827-836.
6. GREEN DR AND REED JC. 1998. Mitochondria and apoptosis. Science 281: 1309-1312.
7. GUSELLA JF, MCNEIL S, PERSICHETTI F, SRINIDHI J, NOVELLETO A, BIRD E, FABER P, VONSATTEL J-P, MYERS R AND MACDONALD ME. 1996. Huntington's Disease. Cold Spring Harbor Symp. Quant Biol 61: 615-626.
8. IKEDA H, YAMAGUCHI M, SUGAI S, AZE Y, NARUMIYA S AND KAKIZUKA A. 1996. Expanded polyglutamine in Machado-Joseph disease protein induces cell death "in vitro and "in vivo". Nature Genet 13: 196-202.
9. JACKSON GR, SALECKER I, DONG X, YAO X, ARNHEIM N, FABER PW, MACDONALD ME AND ZIPURSKY SL. 1998. Polyglutamine-expanded human Huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 21: 633-642.
10. KAWAGUCHI Y, OKAMOTO T, TANIWAKI M, AIZAWA M, INOUE M, KATAYAMA S, KAWAKAMI H, NAKAMURA S, NISHIMURA M, AKIGUCHI I, KIMURA J, NARUMIYA S AND KAKIZUKA A. 1994. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nature Genet 13: 221-228.
11. KLEMENT IA, SKINNER PJ, KAYTOR MD, YI H, HERSCH SM, CLARK HB, ZOGHBI HY AND ORR HT. 1998. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced Disease in SCA1 transgenic mice. Cell 95: 41-53.
12. KOIDE R, IKEUCHI T, ONODERA O, TANAKA H, IGARASHI S, ENDO K, TAKAHASHI H, KONDO R, ISHIKAWA A, HAYASHI T, SAITO M, TOMODA A, MIIKE T, NAITO H, IKUTA F AND TSUJI S. 1994. Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nature Genet 13: 9-13.
13. LA SPADA AR, WILSON EM, LUBAHN DB, HARDING AE AND FISCHBECK KH. 1991. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352: 77-79.
14. LINDSLEY D AND ZIMM GG. 1992. The genome of Drosophila melanogaster. 2nd edn. Academic Press, San Diego, CA.
15. LIS JT, SIMON JA AND SUTTON CA. 1983. New heat shock puffs and Beta Galactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene. Cell 35: 403-410.
16. MACHADO RC. 1997. Análise funcional "in vivo" do locus rst-irreC de Drosophila melanogaster. MSc dissertation, Federal University of Rio de Janeiro. pp 71-72.
17. MANGIARINI L, SATHASIVAM K, SELLER M, COZENS B, HARPER A, HETHERINGTON C, LAWTON M, TROTTIER Y, LEHRACH H, DAVIES SW AND BATES GP. 1996. Exon 1 of the gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87: 493-506.
18. MARTIN P, MARTIN A, OSMANI A AND SOFER W. 1986. A transient expression assay for tissue especific gene expression of alcohol dehydrogenase in Drosophila. Dev Biol 117: 574-580.
19. MILLER DT AND CAGAN RL. 1998. Local induction of patterning and programmed cell death in the developing retina. Development 125: 2327-2335.
20. NAGAFUCHI S, YANAGISAWA H, SATO K, SHIRAYAMA T, OHSAKI E, BUNDO M, TAKEDA T, TADOKORO K, KONDO I, MURAYAMA N ET AL. 1994. Dentato rubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nature Genet 6: 14-18.
21. ORDWAY JM, TALLAKSEN-GREENE S, GUTEKUNST C-A, BERNSTEIN EM, CEARLEY JA, WIENER HW, DURE IV SL, LINDLEY R, HERSCH SM, JOPE RS, ALBIN RL AND DETLOFF PJ. 1997. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell 91: 753-763.
22. PONTING CP, PHILLIPS C, DAVIES KE AND BLAKE DJ. 1997. PDZ domains: targeting signalling molecules to submembranous sites. BioEssays 19: 469-479.
23. RAFF M. 1998. Cell suicide for beginners. Nature 396: 119-122.
24. RAMOS RGP. 1988. Análise funcional do locus Notch de D. melanogaster através de transformação mediada por elementos P. PhD Thesis, Federal University of Rio de Janeiro.
25. RAMOS RGP, IGLOI GL, BAUMANN U, MAIER D, LICHTE B, SCHNEIDER T, BRANDSTÄTTER JH, FRÖHLICH A AND FISCHBACH K-F. 1993. The irregular chiasm C-roughest locus of Drosophila which affects axonal projections and programmed cell death encodes a novel immunoglobulin-like protein. Genes Dev 7: 2533-2547.
26. REITER C, SCHIMANSKY T, NIE Z AND FISCHBACH K-F. 1996. Reorganization of membrane contacts prior to apoptosis in the Drosophila retina: the role of IrreC-rst protein. Development 122: 1931-1940.
27. SAMBROOK J, FRITSCH EF AND MANIATIS T. 1989. Molecular cloning. A laboratory manual. 2nd edn. Cold Spring Harbor laboratory Press, Cold Spring Harbor, NY.
28. SAUDOU F, FINKBEINER S, DEVYS D AND GREENBERG ME. 1998. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95: 55-66.
29. SCHNEIDER T, REITER C, EULE E, BADER B, LICHTE B, NIE Z, SCHIMANSKY T, RAMOS RGP AND FISCHBACH K-F. 1995. Restricted expression of the IrreC-Rst protein is required for normal axonal projections of columnar visual neurons. Neuron 15: 259-271.
30. SPRADLING AC. 1986. P-element mediated transformation. In: Drosophila, a practical approach, (Roberts BD, ed.), IRL Press, Oxford, pp. 175-197.
31. STELLER H AND PIRROTA V. 1984. Regulated expression of genes injected into early Drosophila embryos. EMBO J 3: 165-173.
32. STELLER H AND PIRROTA V. 1985. Fate of DNA injected into early Drosophila embryos. Dev Biol 109: 54-62.
33. STRÜNKELNBERG M, BONENGEL B, MODA LMR, HERTENSTEIN A, DE COUET HG, RAMOS RGP AND FISCHBACH K-F. 2001. rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila. Development 128: 4229-4239.
34. THORNBERRY NA AND LAZEBNICK Y. 1998. Caspases: Enemies within. Science 281: 1312-1316.
35. THUMMEL CS AND PIRROTA V. 1991. New pCasper P-element vectors. Dros Inf Service 71: 150.
36. WARRICK JM, PAULSON HL, GRAY-BOARD GL, BUI QT, FISCHBECK KH, PITTMAN RN AND BONINI NM. 1998. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell 93: 939-949.
37. WHARTON KA, YEDVOBNICK B, FINNERTY VG AND ARTAVANIS-TSAKONAS S. 1985. Opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell 40: 55-62.
38. WOLFF T AND READY D. 1991. Cell death in normal and rough eye mutants of Drosophila. Development 113: 825-839.
39. WOLFF T AND READY D. 1993. Pattern Formation in the Drosophila Retina. In: The Development of Drosophila melanogaster (Bate, M. and Martinez Arias, A., eds) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. pp 1277-1325.