Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands

Farmaco

Volumn 57, Issue 6, 2002, Pages 487-496

  Guandalini, Luca ^a   Dei, Silvia ^a   Manetti, Dina ^a   Romanelli, Maria Novella ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a   Varani, Katia ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Cyclopropyl derivatives; Nicotinic receptor ligands; Structure activity relationships

Indexed keywords

2 [(4 PYRIDYL)CYCLOPROPYL]METHYLAMINE; CYCLOPROPANE DERIVATIVE; IODINE DERIVATIVE; N METHYL [2 (4 PYRIDYL)CYCLOPROPYL]METHYLAMINE; N,N DIMETHYL [2 (3 PYRIDYL)CYCLOPROPYL]METHYLAMINE; N,N DIMETHYL [2 (3 PYRIDYL)CYCLOPROPYL]METHYLAMINE METHIODIDE; N,N DIMETHYL [2 (4 PYRIDYL)CYCLOPROPYL]METHYLAMINE; N,N DIMETHYL [2 (4 PYRIDYL)CYCLOPROPYL]METHYLAMINE METHIODIDE; NICOTINIC AGENT; NICOTINIC RECEPTOR; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; CYCLOPROPYLAMINE; DRUG DERIVATIVE; IODIDE; NICOTINE; PYRIDINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; METABOLISM; RADIOASSAY; SYNTHESIS; THERMODYNAMICS; WISTAR RAT;

ANIMAL; BINDING SITES; CEREBRAL CORTEX; CYCLOPROPANES; IODIDES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; THERMODYNAMICS; ANIMALS;

EID: 0036595897     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01234-X     Document Type: Article

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