Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors

European Journal of Medicinal Chemistry

Volumn 37, Issue 6, 2002, Pages 461-468

  Park, Chang Ha ^a   Siomboing, Xavier ^b   Yous, Saïd ^a   Gressier, Bernard ^b   Luyckx, Michel ^b   Chavatte, Philippe ^a  

^a Yang Ji Chemical Co Ltd   (South Korea)

^b UNIV LILLE   (France)

Author keywords

Cyclooxygenase (COX 1, COX 2); NSAIDs; Selective COX 2 inhibitors; Thromboxane B2

Indexed keywords

1 (3,5 DIFLUOROBENZOYL) 1 (4 METHANESULFONYLPHENYL) 3 ETHYLUREA; 1 (4 FLUOROBENZOYL) 1 (4 METHANESULFONYLPHENYL) 3 ETHYLUREA; 2 (3,4 DICHLOROBENZYLAMINO) 5 METHANESULFONYLPHENYLACETATE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 5 (4 CHLOROPHENYL) 3 METHANESULFONYL 3H INDENO[5,6 D]OXAZOL 2,7 DIONE; ACETYLSALICYLIC ACID; CELECOXIB; CHALCONE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLOSULIDE; IBUPROFEN; INDENONE; LEAD; N [3 (CHLOROPHENYL) 6 METHOXY 1 OXO 1H INDEN 5 YL]METHANESULFONAMIDE; NIMESULIDE; ROFECOXIB; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR MODEL; MONONUCLEAR CELL;

CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; HUMANS; INDICATORS AND REAGENTS; ISOENZYMES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONOCYTES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THROMBOXANE B2;

EID: 0036592250     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01373-9     Document Type: Article

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