Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine

Drug and Alcohol Dependence

Volumn 62, Issue 2, 2001, Pages 141-147

  Mellon, R Daniel ^a   Bayer, Barbara M ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Autonomic nervous system; Immunobiology; Lympbocytes; Nicotinic receptor; Opiates

Indexed keywords

CHLORISONDAMINE; CORTICOSTERONE; MORPHINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CELL ACTIVATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOTOXIC T LYMPHOCYTE; DOSE RESPONSE; DRUG EXPOSURE; DRUG MECHANISM; DRUG MEGADOSE; GANGLION BLOCK; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOTOXICITY; MALE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL;

ANIMALS; CELL MOVEMENT; CHLORISONDAMINE; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; KILLER CELLS, NATURAL; MALE; MORPHINE; NARCOTICS; NICOTINIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN;

EID: 0035314077     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(00)00184-8     Document Type: Article

References (22)

1. Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism
2. Opioids in immunological processes
3. Differential effects of morphine and naltrexone on the antibody response in various mouse strains
4. Evidence for beta adrenergic receptor involvement in the immunomodulatory effects of morphine
5. Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats
6. Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats
7. Potential role of the autonomic nervous system in the immunosuppressive effects of acute morphine administration
8. Acute immunosuppressive effects of morphine: Lack of involvement of pituitary and adrenal factors
9. A mechanism of action for morphine-induced immunosuppression: Corticosterone mediates morphine-induced suppression of natural killer cell activity
10. Measurements of natural killer (NK) activity and NK-cell quantification
11. Immunosuppression by morphine is mediated by central pathways
12. Effects of central administration of morphine on immune status in Lewis and Wistar rats
13. Enkephalins, brain and immunity: Modulation of immune responses by methionine-enkephalin injected into the cerebral cavity
14. Morphine-induced alterations in antibody levels: Receptor and immune mechanisms
15. Evidence for central opioid receptors in the immunomodulatory effects of morphine: Review of potential mechanism(s) of action
16. Role of central opioid receptor subtypes in morphine-induced alterations in peripheral lymphocyte activity
17. Comparison of the time course of morphine's analgesic and immunologic effects
18. Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat
19. Involvement of brain opiate receptors in the immune-suppressive effect of morphine
20. Effect of intracerebroventricularly injected methionine-enkephalin on humoral immune response in the rat
21. Modulation of cutaneous immune reactions by centrally applied methionine-enkephalin
22. The periaqueductal gray matter mediates opiate-induced immunosuppression