Oxidized glucocorticoids counteract glucocorticoid-induced apoptosis in murine thymocytes in vitro

Life Sciences

Volumn 68, Issue 26, 2001, Pages 2905-2916

  Hirano, Toshihiko ^a   Horigome, Hiroshi ^a   Ishishita, Hiroyuki ^a   Uda, Sayaka ^a   Oka, Kitaro ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Attenuation of apoptosis; Glucocorticoid; Negative selection; Oxidized glucocorticoid; Thymocytes

Indexed keywords

11 BETA HYDROXYGLUCOCORTICOID; 11 OXOGLUCOCORTICOID; 20 ALPHA DEHYDROCORTISOL; CD4 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID DERIVATIVE; CORTICOSTERONE; CORTISONE; DEHYDROCORTICOSTERONE; DNA FRAGMENT; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; PREDNISONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; CELL CULTURE; CELL MATURATION; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATION; THYMOCYTE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; COCULTURE TECHNIQUES; CORTICOSTERONE; CORTISONE; DNA; DNA FRAGMENTATION; GLUCOCORTICOIDS; INTRACELLULAR MEMBRANES; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATION-REDUCTION; PHOSPHATIDYLSERINES; PREDNISONE; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0035907001     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01069-4     Document Type: Article

References (23)

1. Cohen JJ, Duke RC. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. Journal of Immunology 1984;132(1):38-42.
2. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980;284:555-6.
3. Walker BR. Organ-specific action of 11β-hydroxysteroid dehydrogenase in humans: Implications for the pathophysiology of hypertension. Steroids 1994;59:84-9.
4. Funder JW, Pearce PT, Smith R, Smith L. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated. Science 1988;242: 583-5.
5. Horigome H, Horigome A, Homma M, Hirano T, Oka K. Glycyrrhetinic acid induced apoptosis in thymocytes: Impact of 11β-hydroxysteroid dehydrogenase inhibition. American Journal of Physiology 1999;277:E624-30.
6. Dougherty TF, Berliner ML, Berliner DL. 11β-Hydroxy dehydrogenase system activity in thymi of mice following prolonged cortisol treatment. Endocrinology 1960:66:550-8.
7. Ohyama K, Oka K, Emura A, Tamura H, Suga T, Bessho T, Hirakawa S, Yamakawa T. Suppression of apoptotic cell death progressed in vitro with incubation of the chorion laeve tissues of human fetal membrane by glucocorticoid. Biological and Pharmaceutical Bulletin 1998:21(10); 1024-9.
8. Castedo M, Hirsh T, Susin SA, Zamzami N, Marchetti P, Macho A, Kromer G. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. Journal of Immunology 1996;157:512-21.
9. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C, A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. Journal of Immunological Method 1995;184:39-51.
10. Horigome A, Hirano T, and Oka K. Tacrolimus-induced apoptosis and its prevention by interleukins in mitogen-activated human peripheral mononuclear cells. Immunopharmacology 1998;39:21-30.
11. Horigome A, Hirano T, Oka K, Takeuchi H, Sakurai E, Kozaki K, Matsuno N, Nagao T, Kozaki M. Glucocorticoids and cyclosporine induce apoptosis in mitogen-activated human peripheral mononuclear cells. Immunopharmacology 1997;37:87-94.
12. Haycock KA, Roth R, Gagnon J. Statview. Berkeley, Calif. Abacus Concepts 1994.
13. Ito M, Watanabe M, Ihara T, Kamiya H, Sakurai M. Fas antigen and bcl-2 expression on lymphocytes cultured with cytomegalovirus and varicella-zoster virus antigen. Cellular Immunology 1995;160:173-7.
14. Homo F, DUval D, Hatzfeld J, Evrard C. Glucocorticoid sensitive and resistant cell populations in the mouse thymocytes. Journal of Steroid Biochemistry 1980;13:135-43.
15. Jondal M, Okret S, McConkey D. Killing of immature CD4+CD8+ thymocytes in vivo by anti-CD3 or 5′-(N-ethyl)-carboxamide adenosine is blocked by glucocorticoid receptor antagonist RU-486. European Journal of Immunology 1993;23:1246-50.
16. Lanza L, Schudeletti M, Puppo F, Bosco O, Peirano L, Filaci G, Fecararotta E, Vidali G, Indiveri F. Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes. Clinical and Experimental Immunology 1996;103:482-90.
17. Oldenburg NBE, Evans-Storms RB, Cidlowski JA. In vivo resistance to glucocorticoid-induced apoptosis in rat thymocytes with normal steroid receptor function in vitro. Endocrinology 1997;138(2):810-8.
18. Murphy BEP. Ontogeny of cortisol-cortisone interconversion in human tissues: A role for cortisone in human fetal development. Journal of Steroid Biochemistry 1981;14:811-7.
19. Jellinck PH, Dhabhar FS, Sakai RR, McEwen BS. Long-term corticosteroid treatment but not chronic stress affects 11β-hydroxysteroid dehydrogenase type I activity in rat brain and peripheral tissues. Journal of Steroid Biochemistry 1997;60(5):319-23.
20. Ranelletti FO, Carmignani M, Iacobelli S, Tonali P. Glucocorticoid-binding components in human thymus hyperplasia. Cancer Research 1978;38(3):516-20.
21. Weyts FA, Verburg-van-Kemenade BM, Flik G. Characterization of glucocorticoid receptors in peripheral blood leukocytes of Carp, Cyprinus carpio L. Gen Comp Endocrinology 1998;111(1):1-8.
22. Van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 1998;31:1-9.
23. Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssiere JL, Petit PX, Kroemer G. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. Journal of Experimental Medicine 1995;181:1661-72.