Immune regulation in Cushing's syndrome: Relationship to hypothalamic-pituitary-adrenal axis hormones

Psychoneuroendocrinology

Volumn 21, Issue 7, 1996, Pages 599-608

  Kronfol, Ziad ^a   Starkman, Monica ^a   Schteingart, David E ^a   Singh, Vijendra ^a   Zhang, Qun ^a   Hill, Elizabeth ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Cushing's syndrome; glucocorticoids; lymphocyte phenotype; natural killer cytotoxicity; neuroimmunomodulation; psychoneuroimmunology

Indexed keywords

BETA ENDORPHIN; CD3 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CORTICOTROPIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOREGULATION; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY;

ADRENOCORTICOTROPIC HORMONE; ADULT; BETA-ENDORPHIN; CD4-CD8 RATIO; CUSHING SYNDROME; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; PSYCHONEUROIMMUNOLOGY; REFERENCE VALUES; T-LYMPHOCYTE SUBSETS;

EID: 0030267521     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(96)00021-2     Document Type: Article

References (25)

1. Andrusenko AB, Kalinin AP, Ol'shanskii AA, Donskov SI, Tishenina RS (1985) Immunologic indices in Itsenko-Cushing disease. Probl Endokrinol (Mosk) 31:33-36.
2. Bateman A, Singh A, Kral T, Solomon S (1989) The immune hypothalamic-pituitary-adrenal axis. Endocr Rev 10:92-112.
3. Bloom ET, Korn EL (1983) Quantification of natural cytotoxicity by human lymphocyte subpopulations isolated by density: Heterogeneity of the effector cells. J Immunol Meth 58:323-335.
4. Britton S, Thoren M, Sjoberg HE (1975) The immunoogical hazard of Cushing's syndrome. Br Med J 4:678-680.
5. Buzzetti R, McLoughlin L, Scavo D, Rees LH (1989) A critical assessment of the interactions between the immune system and the hypothalamic-pituitary-adrenal axis. J Endocrinol 120:183-187.
6. Claman HN (1972) Corticosteroids and lymphoid cells. N Engl J Med 287:388.
7. Cupps T, Fauci AS (1982) Corticosteroid-mediated immunoregulation in man. Immunol Rev 65:133-155.
8. Dougherty TF, White A (1943) Influence of adrenal cortical secretion on blood elements. Science 98:367.
9. Fauci AS, Dale CD, Barlow JE (1976) Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Int Med 84:304-315.
10. Gatti G, Cavallo R, Sartori ML, del Ponte D, Masera R, Salvadori A, Cariguola R, Anjeli A (1987) Inhibition by cortisol of human natural killer (NK) cell activity. J Ster Biochem 26:49.
11. Keller SE, Weiss JM, Schleifer SJ, Stein M (1981) Suppression of immunity by stress: effect of a graded series of stressors on lymphocyte stimulation in the rat. Science 213:1397-1400.
12. Kiecolt-Glaser JK, Glaser R, Strain E, Stout J, Tarr K, Holliday J, Speicher C (1986) Modulation of cellular immunity in medical students. J Behav Med 212:1100.
13. Kronfol Z, Nair M, Hill E, Kroll P, Brower K, Greden J (1993) Immune function in alcoholism: a controlled study. Alcohol Clin Expl Res 17:279-283.
14. Kronfol Z, Nair M, Zhang Q, Hill E, Brown MB (1997) Circadian immune measures in healthy volunteers: Relationship to hypothalamic-pituitary-adrenal axis hormones and sympathetic neurotransmitters. Psychosom Med (in press).
15. Munck A, Guyre P (1991) Glucocorticoids and immune function. In Ader R, Felten D, Cohen N (Eds) Psychoneuroimmunology, 2nd edn. Academic Press, San Diego, pp 447-474.
16. Nair MPN, Schwartz SA (1983) Immunomodulatory effects of corticosteroids on natural killer and antibody-dependent cellular cytotoxic activities of human lymphocytes. J Immunol 101:479-487.
17. Okamoto T, Obara T, Ito Y, Izuo M, Yamashita T, Kanaji Y, Tanaka R, Ihara M (1993) Relative lymphopenia in Cushing's syndrome. Fol Endocrinol Jpn 69:636-640.
18. Riley V (1981) Psychoneuroendocrine influences on immunocompetence and neoplasia. Science 212:1100.
19. Sauer J, Stella GK, Muller OA, Arzt E (1994) Inhibition of interleukin-2 mediated lymphocyte activation in patients with Cushing's syndrome: a comparison with hypocortisolemic patients. Neuroendocrinology 59:144-151.
20. Shavit Y, Lewis JW, Terman GW, Gale RP, Liebeskind JC (1984) Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. Science 233:188-190.
21. Shohat B, Klein A, Kaufman H, Blum I, Chowers I (1979) T lymphocytes and plasma inhibitory factor in ACTH-dependent Cushing's patients. Clin Immunol Immunopathol 13:452-461.
22. Slade J, Hepburn B (1983) Prednisone-induced alterations of circulating human lymphocyte subsets. J Lab Clin Med 101:479-487.
23. Starkman M, Schteingart DE, Schork MA (1992) Discordant changes in plasma ACTH and β-lipotropin/β-endorphin levels in Cushing's disease patients with depression. Psychoneuroendocrinology 17:619-626.
24. Streeten DHP, Stevenson CT, Dalakos TG, Nicholas JJ, Dennick LG, Fellerman H (1965) The diagnosis of hypercorticolism: biochemical criteria differentiating patients from lean and obese normal subjects and from females on oral contraceptives. J Clin Endocrinol 29:1191-1211.
25. Wurzburger MI, Prelevic GM, Brick SD, Vuckovic S, Pendic B (1986) Cushing's syndrome: transitory immune-deficiency state? Postgrad Med J 62:657-659.