A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 5 40-5, 1996, Pages

  Pannen, Benedikt H J ^b   Bauer, Michael ^b   Zhang, Jian X ^b   Robotham, James L ^b   Clemens, Mark G ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b NONE

Author keywords

bosentan; hemodynamics; liver; microcirculation; N( ) nitro L arginine methyl ester; portal vein; pressure flow analysis; videomicroscopy

Indexed keywords

BOSENTAN; ENDOTHELIN; ENDOTOXIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ARTICLE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HEMODYNAMICS; ISOLATED LIVER; MALE; MICROCIRCULATION; NONHUMAN; PORTAL VEIN; PORTAL VEIN BLOOD FLOW; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT; VEIN RESISTANCE;

EID: 33750700881     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.5.h1953     Document Type: Article

References (34)

1. Ayuse, T., N. Brienza, C. P. O'Donell, and J. L. Robotham. Pressure-flow analysis of portal vein and hepatic artery interactions in porcine liver. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1233-H1243, 1994.
2. Ayuse, T., N. Brienza, J. P. Revelly, J. K. Boitnott, and J. L. Robotham. The role of nitric oxide in the porcine liver circulation under normal and endotoxemic conditions. J. Appl. Physiol. 78: 1319-1329, 1990.
3. Ayuse, T., N. Brienza, J. P. Revelly, C. P. O'Donnell, J. K. Boiitnot, and J. L. Robotham. Alterations in liver hemodynamics and pressure-flow relationships in an intact porcine model of endotoxin shock. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1106-H1114, 1995.
4. Bauer, M., J. X. Zhang, I. Bauer, and M. G. Clemens. Endothelin-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G143-G149, 1994.
5. Bohlen, H. G., R. Maass-Moreno, and C. F. Rothe. Hepatic venular pressures of rats, dogs, and rabbits. Am. J. Physiol. 261 (Gastrointest Liver Physiol. 24): G539-G547, 1991.
6. Brienza, N., T. Ayuse, C. P. O'Donnell, S. Permutt, and J. L. Robotham. Regional control of venous return: liver blood flow. Am. J. Respir. Crit Care Med. 152: 511-518, 1995.
7. Chun, K., J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens. Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers. Shock 1: 3-9, 1994.
8. 2 treatment. Am. J. Physiol. 248 (Heart Circ. Physiol. 17): H804-H811, 1985.
9. Clozel, M., V. Breu, G. A. Gray, B. Kalina, B.-M. Löffler, K. Burri, J.-M. Cassal, G. Hirth, M. Müller, W. Neidhart, and H. Ramuz. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J. Pharmacol. Exp. Ther. 270: 228-235, 1994.
10. Cook, H. T., A. J. Bune, A. S. Jansen, G. M. Taylor, R. K. Loi, and V. Cattell. Cellular localization of inducible nitric oxide synthase in experimental endotoxic shock in the rat. Clin. Sci. Lond. 87: 179-186, 1994.
11. Ehrenreich, H., R. Anderson, C. Fox, P. Rieckmann, G. Hoffman, W. Travis, J. Coligan, and A. Fauci. Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J. Exp. Med. 172: 1741-1748, 1990.
12. Evans, T., A. Carpenter, and J. Cohen. Purification of a distinctive form of endotoxin-induced nitric oxide synthase from rat liver. Proc. Natl. Acad. Sci. USA 89:5361-5365, 1992.
13. Gaillard, T., A. Mulsch, R, Busse, H. Klein, and K. Decker. Regulation of nitric oxide production by stimulated rat Kupffer cells. Pathobiology 59: 280-283, 1991.
14. Geller, D. A, C. J. Lowenstein, R. A. Shapiro, A. K. Nussler, M. DiSilvio, S. C. Wang, D. K. Nakayama, R. L. Simmons, S. H. Snyder, and T. R. Billiar. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA 90: 3491-3495, 1993.
15. Gross, J. F., and J. Aroesty. Mathematical models of capillary flow: a critical review. Biorheology 9: 225-264, 1972.
16. Harbrecht, B. G., T. R. Billiar, J. Stadler, A. J. Demetris, J. B. Ochoa, R. D. Curran, and R. L. Simmons. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J Leukocyte Biol. 52: 390-394, 1992.
17. Kawada, N., T.-A. Tran-Thi, H. Klein, and K Decker. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur. J. Biochem. 213: 815-823, 1993.
18. Maass-Moreno, R., and C. F. Rothe. Contribution of the large veins to postsinusoidal vascular resistance. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G14-G22, 1992.
19. Marsden, P., and B. Brenner. Transcriptional regulation of the endothelin-1 gene by TNF-α. Am. J. Physiol. 262 (Cell Physiol. 31): C854-C861, 1992.
20. McCuskey, R. S., and F. D. Reilly. Hepatic microvasculature: dynamic structure and its regulation. Sem. Liver Dis. 13: 1-12, 1993.
21. Mitzner, W. Hepatic outflow resistance, sinusoid pressure, and the vascular waterfall. Am. J. Physiol. 227: 513-519, 1974.
22. Nishida, J., R. S. McCuskey, D. McDormell, and E. S. Fox. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1135-G1141, 1994.
23. Oshita, M., Y. Takei, S. Kawano, H. Yoshihara, T. Hijioka, H. Fukui, M. Goto, E. Masuda, Y. Nishimura, and H. Fusamoto. Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in the rat liver. J. Clin. Invest. 91: 1337-1342, 1993.
24. Pannen, B. H. J., M. Bauer, J. X. Zhang, J. L. Robotham, and M. G. Clemens. Endotoxin pretreatment enhances the portal venous contractile response to endothelin-1. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H7-H15, 1996.
25. Rieder, H., G. Ramadori, and K. H. Meyer zum Bueschenfelde. Sinsusoidal endothelial liver cells in vitro release endothelin - augmentation by transforming growth factor β and Kupffer cell conditioned media. Klin. Wochenschr. 69: 387-391, 1991.
26. Rockey, D. C. Characterization of endothelin receptors mediating rat hepatic stellate cell contraction. Biochem. Biophys. Res. Commun. 207: 725-731, 1995.
27. Rockey, D. C., and J. J. Chung. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J. Clin. Invest. 95: 1199-1206, 1995.
28. Shrier, I., and S. Magder. Response of arterial resistance and critical pressure to changes in perfusion pressure in canine hindlimb. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1939- H1945, 1993.
29. Sugiura, M., T Inagami., and V. Kon. Endotoxin stimulates endothelin release in vivo and in vitro as determined by radioimmunoessay. Biochem. Biophys. Res. Commun. 161: 1220-1227, 1989.
30. Tran-Thi, T.-A., N. Kawada, and K. Decker. Regulation of endothelin-1 action on the perfused rat liver. FEBS Lett. 318: 353-357, 1993.
31. B receptor in endothelial cells. Receptor coupling to nitric oxide synthase. J. Biol. Chem. 269: 21778-21785, 1994.
32. Wettstein, M., W. Gerok, and D. Häussinger. Endotoxin- induced nitric oxide synthesis in the perfused rat liver: effects of L-arginine and ammonium chloride. Hepatology Baltimore 19: 641-647, 1994.
33. Zhang, J. X., M. Bauer, and M. G. Clemens. Vessel and target cell specific actions of endothelin-1 and endothelin-3 in rat liver. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G269-G277, 1995.
34. Zhang, J. X., W. Pegoli, and M. G. Clemens. Endothelin-1 induces direct constriction of hepatic sinusoids. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G624-G632, 1994.