Hyperproinsulinemia and proinsulin-to-insulin ratios in Swedish middle-aged men: Association with glycemia and insulin resistance but not with family history of diabetes

American Journal of Epidemiology

Volumn 155, Issue 9, 2002, Pages 834-841

  Grill, Valdemar ^a,b   Dinesen, B ^c   Carlsson, S ^d   Efendic, S ^a   Pedersen, O ^c   Ostenson C G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c STENO DIABETES CENTER   (Denmark)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Birth weight; Diabetes mellitus, non insulin dependent; Glucose intolerance; Insulin; Insulin intolerance; Obesity; Proinsulin

Indexed keywords

GLUCOSE; INSULIN; PROINSULIN;

BODY SIZE; DIABETES; DISEASE PREVALENCE;

ADULT; ARTICLE; BIRTH WEIGHT; DISEASE ASSOCIATION; FAMILY HISTORY; GLUCOSE BLOOD LEVEL; HEREDITY; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; SWEDEN; WORLD HEALTH ORGANIZATION;

ADULT; AGE FACTORS; BIRTH WEIGHT; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INFANT, NEWBORN; INSULIN; MALE; MIDDLE AGED; PROINSULIN; REGRESSION ANALYSIS; SWEDEN;

SWEDEN;

EID: 0036570116     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/155.9.834     Document Type: Article

References (34)

1. Circulating proinsulin in patients with maturity onset diabetes
2. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulindependent) diabetes mellitus and in experimental insulin resistance
3. Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
4. Insulin deficiency in non-insulin-dependent diabetes
5. Familial hyperproinsulinemia. An autosomal dominant defect
6. Plasma proinsulin in first-degree relatives of type 2 diabetic subjects
7. Higher proinsulin and specific insulin are both associated with a parental history of diabetes in nondiabetic Mexican-American subjects
8. Effects of genetic predisposition on proinsulin responses in Asian Indians
9. Intact proinsulin, des 31,32 proinsulin, and specific insulin concentrations among nondiabetic and diabetic subjects in populations at varying risk of type 2 diabetes
10. C. Proinsulin immunore activity in identical twins discordant for non-insulin-dependent diabetes mellitus
11. Hyperpro insulinemia of type 2 diabetes is not present before the development of hyperglycemia
12. Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM
13. Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus
14. Enhancement of Β-cell secretion by blood glucose normalization in type 2 diabetes is associated with fasting C-peptide levels
15. Relative hyperproinsulinemia of NIDDM persists despite the reduction of hyperglycemia with insulin or sulfonylurea therapy
16. Age-related alteration of pancreatic beta-cell function. Increased proinsulin and proinsulin-to-insulin ratio in elderly, but not in obese, subjects without glucose intolerance
17. Insulin resistance does not change the ratio of proinsulin to insulin in normal volunteers
18. The relation of proinsulin, insulin, and proinsulin: Insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects
19. The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: The Insulin Resistance Atherosclerosis Study
20. Hyperinsulinemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance
21. Thinness at birth and insulin resistance in adult life
22. Birth weight and the metabolic syndrome: Thrifty phenotype or thrifty genotype?
23. Family history of diabetes in middle-aged Swedish men: A gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects
24. Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men
25. Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men
26. World Health Organization
27. Coated charcoal immunoassay of insulin
28. Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies
29. Hyperproinsulinemia is associated with increased beta cell demand after hemipan-createctomy in humans
30. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus
31. Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets
32. Effect of glucocorti coid and growth hormone treatment on proinsulin levels in humans
33. Abdominal obesity increases overnight cortisol secretion
34. Elevated plasma cortisol concentrations: A link between low birth weight and the insulin resistance syndrome?