Insulin resistance does not change the ratio of proinsulin to insulin in normal volunteers

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 10, 1997, Pages 3221-3224

  Wang, Pei Wen ^b   Abbasi, Fahim ^b   Carantoni, Marcello ^b   Chen, Yii Der I ^b   Azhar, Salman ^b   Reaven, Gerald M ^a  

^a Shaman Pharmaceuticals Inc   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROINSULIN;

ADULT; ARTICLE; DIET RESTRICTION; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; BLOOD GLUCOSE; FEMALE; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; PROINSULIN; REFERENCE VALUES;

EID: 0030921180     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.10.3221     Document Type: Article

References (29)

1. Temple RC, Carrington CA, Luzio SD, et al. 1989 Insulin deficiency in non-insulin-dependent diabetes. Lancet. 1:293-295.
2. Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y. 1988 Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 31:335-360.
3. Saad MF, Kahn SE, Nelson RG, et al. 1990 Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 70:1247-1253.
4. Reaven GM, Chen YDI, Hollenbeck CB, Sheu WHH, Ostrega D, Polonsky K. 1993 Plasma insulin C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab. 76:44-48.
5. Reaven GM, Miller R. 1968 Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes. 17:560-569.
6. Sicree RA, Zimmet PZ, King HOM, Coventry JS. 1987 Plasma insulin response among Nauruans: prediction of deterioration in glucose tolerance over 6 yrs. Diabetes. 36:179-186.
7. Saad MF, Pettit DJ, Mott DM, Knowler WC, Nelson RG, Bennett PH. 1989 Sequential changes in serum insulin concentration during development of non-insulin-dependent diabetes. Lancet. 1:1356-1359.
8. Haffner SM, Stern MP, Mitchell BD, Hazuda HP, Patterson JK. 1990 Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes. 39:283-288.
9. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. 1990 Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of the diabetic parents. Ann Intern Med. 113:909-915.
10. Ginsberg H, Kimmerling G, Olefsky JM, Reaven GM. 1975 Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia. J Clin Invest. 55:454-461.
11. Reaven GM, Bernstein R, Davis B, Olefsky JM. 1976 Non-ketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med. 60:80-88.
12. Reaven GM. 1983 Insulin resistance in noninsulin-depondent diabetes mellitus: does it exist and can it be measured? Am J Med. 74(Suppl 1A):3-17.
13. Hollenbeck C, Reaven GM. 1987 Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab. 64:1169-1173.
14. Reaven GM, Brand RJ, Chen YDI, Mathur AK, Goldfinel. 1993 Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes. 42:1324-1332.
15. National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
16. Kadish AH, Litle RL, Sternberg JC. 1963 A new and rapid method for determination of glucose by measurement of rate of oxygen consumption. Clin Chem. 14:116-131.
17. Hales CN, Randle PJ. 1963 Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 88:137-146.
18. Harano Y, Ohgaku S, Hidaka H, Haneda K, Kikkawa R, Shigeta Y, Abe H. 1977 Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J Clin Endocrinol Metab. 45:1124-1127.
19. Shen SW, Reaven GM, Farquhar JW. 1970 Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest. 49:2151-2160.
20. Bowsher RR, Wolny JD, Frank BH. 1992 A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum. Diabetes. 41:1084-1090.
21. Shimizu M, Kawazu S, Tomono S, Ohno T, Utsugi T, et al. 1996 Age-related alteration of pancreatic β-cell function. Diabetes Care. 19:8-11.
22. Haffner SM, Mykkänen L, Valdez RA, et al. 1994 Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J Clin Endocrinol Metab. 79:1806-1810.
23. Birkeland KI, Torjesen PA, Eriksson J, Vaaler S, Groop L. 1994 Hyperinsulinemia of type II diabetes is not present before the development of hyperglycemia. Diabetes Care. 17:1307-1310.
24. Clark M, Levy JC, Cox L, Burnett M, Turner RC, Hales CN. 1992 Immunoradiometric assay of insulin, intact proinsulin and 32-33 split proinsulin and radioimmunoassay of insulin in diet-treated type 2 (non-insulin-dependent) diabetic subjects. Diabetologia. 35:469-474.
25. Davies MJ, Rayman G, Gray IP, Day JL, Hales CN. 1993 Insulin deficiency and increased plasma concentration of intact and 32/33 spit proinsulin in subjects with impaired glucose tolerance. Diabetic Med. 10:313-320.
26. Haffner SM, Bowsher RR, Mykkänen L, et al. 1994 Proinsulin and specific insulin concentration in high and low-risk populations for NIDDM. Diabetes. 43:1490-1493.
27. Byrne MM, Sturis J, O'Meara NM, Polonsky KS. 1995 Insulin secretion in insulin-resistant women with a history of gestational diabetes. Metabolism 44:1067-1073.
28. Hanson U, Persson B, Hartling SG, Binder C. 1996 Increased molar proinsulin-to-insulin ratio in women with previous gestational diabetes does not predict later impairment of glucose tolerance. Diabetes Care. 19:17-20.
29. Haffner SM, Stern MP, Miettinen H, Gingerich R, Bowsher RR. 1995 Higher proinsulin and specific insulin are both associated with a parental history of diabetes in nondiabetic Mexican-American subjects. Diabetes. 44:1156-1160.