Increased expression of CHK2 in human gastric carcinomas harboring P53 mutations

International Journal of Cancer

Volumn 99, Issue 1, 2002, Pages 58-62

  Shigeishi, Hideo ^a,b   Yokozaki, Hiroshi ^a,b   Oue, Naohide ^a,b   Kuniyasu, Hiroki ^a,b   Kondo, Tomohiro ^a,b   Ishikawa, Takenori ^a,b   Yasui, Wataru ^a,b  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cell cycle; Chk2; Chkl; Gastric carcinoma; P53

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; PROTEIN KINASE; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA, PAPILLARY; AGED; BLOTTING, WESTERN; DNA PRIMERS; FEMALE; GASTRIC MUCOSA; GENES, P53; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0036568522     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10272     Document Type: Article

References (37)

1. Cell cycle control and cancer
2. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
3. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase
4. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2
5. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to cdk regulation through Cdc25c
6. 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of cdc25C on serine-216
7. Cell cycle-dependent and ATM-independent expression of human Chk1 kinase
8. 2/M DNA damage checkpoint
9. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
10. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
11. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
12. p53, the cellular gatekeeper for growth and division
13. The p53 network
14. A role for ATR in the DNA damage-induced phosphorylation of p53
15. A single ataxia-telangiectasia gene with a product similar to PI-3 kinase
16. 1 cell cycle checkpoint pathway and ataxia-telangiectasia
17. ATM associates with and phosphorylates p53: Mapping the region of interaction
18. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
19. 1 by stabilizing p53
20. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
21. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
22. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
23. Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer
24. Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium
25. Absence of germline CHK2 mutations in familial gastric cancer
26. cdc2 and its kinase activity in human gastric and colonic carcinomas
27. Frequent p53 gene mutations in serrated adenomas of the colorectum
28. Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas
29. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
30. Genetic and epigenetic alterations in multistep carcinogenesis of the stomach
31. p53 point mutations in primary human gastric carcinomas
32. Genetic and epigenetic changes in stomach cancer
33. ATM: A mediator of multiple response to genotoxic stress
34. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
35. p53 down-regulates Chk1 through p21 and the retinoblastoma protein
36. The p53 tumor suppressor gene: From molecular biology to clinical investigation