Genetic and epigenetic alterations in multistep carcinogenesis of the stomach

Journal of Gastroenterology

Volumn 35, Issue SUPPL. 12, 2000, Pages 111-115

  Yasui, Wataru ^a   Yokozaki, Hiroshi ^a   Fujimoto, Junya ^a   Naka, Kazuhito ^a   Kuniyasu, Hiroki ^a   Tahara, Eiichi ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell cycle regulators; Epigenetic alterations; Gastric cancer; Genetic alterations; Telomerase

Indexed keywords

CELL ADHESION MOLECULE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; DNA; GROWTH FACTOR RECEPTOR; INTESTINAL TREFOIL FACTOR; PROTEIN P27; PROTEIN P53; PROTEIN P73; PROTEIN PS2; RNA DIRECTED DNA POLYMERASE; TELOMERASE; TRANSCRIPTION FACTOR E2F;

CANCER GENETICS; CANCER GRADING; CELL CYCLE PARAMETERS; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVATION; EPITHELIUM CELL; GENE AMPLIFICATION; GENETIC STABILITY; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; STOMACH CARCINOGENESIS; TELOMERE; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; DNA-BINDING PROTEINS; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PRECANCEROUS CONDITIONS; RNA; STOMACH NEOPLASMS; TELOMERASE;

EID: 0034108311     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Tahara E, Semba S, Tahara H. Molecular biological observations in gastric cancer. Semin Oncol 1996;23:307-15.
2. Tahara E, Yokozaki H, Yasui W. Stomach: genetic and epigenetic alterations of preneoplastic and neoplastic lesions. In: Srivastava S, Henson DE, Gazdar A, editors. Molecular pathology of early cancer. Amsterdam: IOS Press; 1999. pp. 341-61.
3. Yokozaki H, Kuniyasu H, Semba S, Yasui W, Tahara E. Molecular bases of human stomach carcinogenesis. In: Tahara E, editor. Molecular pathology of gastroenterological cancer: application to clinical practice. Tokyo: Springer; 1997. pp. 55-70.
4. Prives C, Hall PA. The p53 pathway. J Pathol 1999;187:112-26.
5. Tahara E. Molecular mechanism of human stomach carcinogenesis implicated in Helicobacter pylori infection. Exp Toxic Pathol 1998;50:375-8.
6. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, et al. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999;59: 1090-5.
7. Lefebvre O, Chenard M-P, Masson R, Linares J, Dierich A, LeMeur M, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 1996;274:259-62.
8. Kanai Y, Ushijima S, Ochiai A, Eguchi K, Hui A-M, Hirohashi S. DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett 1998;122:135-41.
9. Bhattacharya SK, Tamchandani S, Cervoni N, Szyf M. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 1999;397:579-83.
10. Luo RX, Postigo AA, Dean DC. Rb interacts with histone deacetylase to repress transcription. Cell 1998;92:463-73.
11. Tahara H, Kuniyasu H, Yokuzaki H, Yasui W, Shay JW, Ide T, et al. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions. Clin Cancer Res 1995;1:1245-51.
12. Yasui W, Tahara H, Tahara EJ, Fujimoto J, Nakayama J, Ishikawa F, et al. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas. Jpn J Cancer Res 1998;89:1099-103.
13. Yasui W, Tahara, EJ, Tahara H, Fujimoto J, Naka K, Nakayama J, et al. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach. Jpn J Cancer Res 1999;90:589-95.
14. Kuniyasu H, Domen T, Hamamoto T, Yokozaki H, Yasui W, Tahara H, et al. Expression of human telomerase RNA is an early event of stomach carcinogenesis. Jpn J Cancer Res 1997;88:103-7.
15. Yasui W, Yokozaki H, Shimamoto F, Tahara H, Tahara E. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology. Pathol Int 1999;49:763-74.
16. Kipl is associated with advanced stage and invasiveness of gastric carcinomas. Jpn J Cancer Res 1997;88:625-9.
17. Kipl, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma. Oncol Rep 1999;6:983-7.
18. Dyson N: The regulation of E2F by pRB-family proteins. Genes Dev 1998;12:2245-62.
19. Suzuki T, Yasui W, Yokozaki H, Naka K, Ishikawa T, Tahara E. Expression of the E2F family in human gastrointestinal carcinomas. Int J Cancer 1999;81:535-8.
20. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan J-C, Valent A, et al. Monoallelically expressed gene related to p53 at lp36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-19.
21. Yokozaki H, Shitara Y, Fujimoto J, Hiyama T, Yasui W, Tahara E. Alterations of p73 gene preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype. Int J Cancer 1999; 83:192-6.